17 papers · ranked by Valyu relevance
Veronica Salmaso, Silvia Menin, Stefano Moro, Giampiero Spalluto + 3 more
Adenosine plays a crucial role in various pathophysiological conditions, including neuroinflammation and neurodegeneration. Neuroinflammation can be either beneficial or detrimental to the central nervous system, depending on the intensity and duration of the inflammatory response. Across a wide range of brain…
Paola Imbriani, Clara D’Ambra, Roberta De Mori, Marta Ionta + 5 more
Bidirectional communication between the central nervous system and the immune system is crucial for brain function, particularly in regulating neuroplasticity: on the one hand, glial cells modulate neuronal function, brain circuitry, axon myelination, dendritic spine architecture, and information processing, while on…
Savina Apolloni, Sushruta Koppula
More than 600 brain diseases have been identified [1], and neuroinflammation is implicated in nearly all of them. Complex and disorder-specific changes in the immune response underlie the pathogenesis of primary neurological and neuropsychiatric conditions from pediatric to geriatric disorders. These include…
Mario Caldarelli, Pierluigi Rio, Antonio Gasbarrini, Giovanni Gambassi + 2 more
Environmental exposures are widely recognized as major risk factors for human health. According to projections by the World Health Organization, climate change is expected to cause a significant increase in mortality within the next few decades. Environmental factors, including diet, weather, occupational exposures…
Qingqing Tang, Min He, Peng Zheng, Mengmeng Sun + 6 more
Neuroinflammation represents the central pathological process in neurological disorders. Effectively regulating neuroinflammation to restore immune homeostasis and alleviate neuronal damage has emerged as a critical strategy in the prevention and treatment of these diseases. In recent years, the role of acupuncture in…
Yimao Wu, Weiqi Lyu, Xiaofei Xie, Xiao Fu + 2 more
The bidirectional interaction between immune cells and neural cells is the core effector unit of neuroinflammation, determining whether the central nervous system (CNS) maintains homeostasis or develops disease. Under physiological conditions, this interaction supports CNS homeostasis through microglial surveillance…
Ana B. de Araújo, Francisco V. C. S. Azul, Yandra Cardoso Carneiro, Caren N. S. de Sousa + 3 more
and Oxidative Stress in Parkinson’s Disease, Alzheimer’s Disease, and COVID-19: Microglia–Neutrophil Interaction Authors: Ana B. de Araújo, Francisco V. C. S. Azul, Yandra Cardoso Carneiro, Caren N. S. de Sousa, Silvânia M. M. de Vasconcelos, Francisco J. Rios, Luzia K. A. M. Leal Abnormal activation of the immune…
Maria Concetta Geloso, Gabriele Di Sante, Alberto Granato, Evelyne Gozal
Neuroinflammation is increasingly recognized as a major contributor to cognitive and neuropsychiatric dysfunction. The prefrontal cortex (PFC), a key substrate for executive functions and emotional behaviors, appears particularly vulnerable to inflammatory insults due to its high metabolic demand, prolonged…
Suhua Chang, Yushan Guan, Qinrui Li, Pin Wan + 2 more
Neuroinflammation is now recognized as a central component of many neurological and psychiatric disorders, ranging from classical neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Amyotrophic lateral sclerosis (ALS), and Multiple sclerosis (MS) to brain injury, vascular disease…
Baoyin Zhou, Binbin Hu
Neuroinflammation arises from the synergistic interplay of multiple inflammatory mediators and is pathologically associated with various neurological disorders. These conditions are complex, multifactorial diseases characterized by dynamic interactions between chronic neuroinflammation, oxidative stress, and…
Junhui Wang, Hongxing Wang, Dirk M. Hermann
Neurodegenerative diseases (NDs), including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), represent a major and growing global health challenge. These disorders are characterized by the progressive loss of neuronal structure and function within…
Yahui Li, Kunfeng Duan, Guangyuan Liu, Jingwen Yan + 7 more
Title: Summary Neuroinflammation is a pivotal pathological process underlying numerous neurological disorders. While the interplay between neuroinflammation and glycosylation is gaining increasing attention, it remains unclear whether modulating glycosylation can effectively inhibit neuroinflammation. To address this…
Boyang Qiu, Yichen Zhuo, Zixin Teng, Wendi Yue + 10 more
Glycine tabacina (Labill.) Benth is commonly known as “Yan-Dou” and is a folk medicinal herb in China used to alleviate rheumatism. Although its anti-inflammatory and antioxidant activities have been reported, its effects on microglia-driven neuroinflammation, neuronal protection, and neuroinflammation-associated…
Masaru Tanaka, Muskan Gupta
Highlights What are the main findings?1. Five mechanistic gaps were defined that shape the neurogenesis-neuroinflammation dialogue in aging. 2. Translational strategies such as imaging, immunomodulation, and glial reprogramming offer testable intervention pathways. What is the implication of the main finding?1. Tuning…
Ludmila Müller, Svetlana Di Benedetto, Viktor Müller
Neuroinflammation has emerged as a central component of brain aging, shaping the balance between neural resilience and vulnerability to cognitive decline. Rather than representing a simple consequence of neuronal damage, neuroinflammatory processes are increasingly recognized as active regulators of synaptic integrity…
Xinna Wang, Hang Chen, Yan Xu, Hongtao Cui + 1 more
Uncontrolled neuroinflammation following cerebral ischemia-reperfusion is a core pathophysiological process driving secondary brain injury and leading to long-term neurological dysfunction. For decades, traditional “anti-inflammatory” strategies targeting the inhibition of key pro-inflammatory pathways have repeatedly…
Errin Lawrence, Daniel Fulton, Poppy Brown, Subashini Suresh + 11 more
4.1### The Brain Immune Microenvironment The brain maintains a specialized immune microenvironment in which multiple cellular populations participate in surveillance, homeostasis, and response to injury. Resident microglia, the principal brain-specific immune cells, continuously survey the parenchyma. Border-associated…