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Search · four archives
12 papers · ranked by Valyu relevance
Jalaja Madhusudhanan, Anton Parinov, Charles Fieseler, Manuel Zimmer
Behavior arises from the interplay between spontaneous brain dynamics and sensory-driven responses, yet how spontaneous neural activity shapes variability in decision-making remains unclear. We leverage the tractable C. elegans nervous system to address this question. During oxygen avoidance, we observe binary…
Jeffrey D. Walker, Paul Aparicio, Shreya Saxena, Nicholas G. Hatsopoulos + 1 more
The ability to record neural populations during natural behavior now allows us to ask whether canonical motor-cortical dynamics, defined largely in constrained reaches to static targets, also organize self-paced, feedback-rich actions that require continuous correction. We recorded sensorimotor cortex in marmosets…
Justin D Shin, Michael Satchell, Paul Miller, Shantanu P Jadhav + 2 more
REM (rapid eye movement) and non-REM (NREM) sleep stages contribute to systems memory consolidation in hippocampal-cortical circuits. However, the physiological mechanisms underlying REM memory processes remain relatively unclear compared to NREM memory reactivation. Here we report, in rodents, the existence of…
Yi Ren, Zimei Chen, Hayden Deans, Ying Nian Wu + 1 more
Extensive studies suggest the brain performs Bayesian inference to infer the latent world states. It is a fundamental neuroscience question that how canonical recurrent neural circuits in the brain implement Bayesian inference. Many existing theoretical studies focused on how the recurrent circuits compute the…
Filippo Groppi, Jessica Ferrari
Spontaneous population bursts repeatedly expose synapses to correlated spike activity, but it is unclear whether such events reinforce pre-existing synaptic weight differences when precise firing order carries little information. We asked this in a conductance-based model of a bursting neuronal culture: 48 excitatory…
Li Zhang, Haicheng Rao, Mengge Li, Xiaobo Qian + 3 more
Single-cell atlas annotations are routinely treated as ground truth but rarely validated before use. We present AnnoAudit, a marker-based audit protocol that combines four convergent checks—marker scoring, unsupervised clustering, margin-gated module scoring, and applicability-gated pretrained models—into a composite…
Yi Wang, Jin Shan, Chenglong Zhang, Zhenhu Jin + 3 more
Neuronal magnetic signal recording intrinsically provides vector information and tissue transparency, offering a potential route to overcome the spatial resolution limitations of conventional electrophysiological recordings. However, in situ detection of neuronal magnetic signals at the cellular level remains highly…
Sabine Sommerer, Kristen Rak, Bjoern Spahn, Stephan Hackenberg + 3 more
Vestibular dysfunction significantly contributes to dizziness, balance issues, and falls, yet causal treatments are still unavailable. The vestibular ganglion (VG), the primary sensory ganglion of the vestibular nerve, is increasingly seen as a key site of vestibular degeneration. Neural stem cells (NSCs) have been…
Eva Lemoine, Brendan Lenfesty, Umesh Kumar Naik Mudavath, Saugat Bhattacharyya + 1 more
Echo state networks (ESNs) are efficient, neuro-inspired computational frameworks well suited to time-series data. However, ESN decision confidence is typically quantified in limited ways. We propose an explicit decision-confidence readout neuron, trained from decision readout outputs, to continuously monitor…
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes + 11 more
Gene therapies using adeno-associated viruses (AAVs) for central nervous system (CNS) disorders face challenges because host immune responses are not represented in classical preclinical models. Here, we present a human-induced pluripotent stem cell (hiPSC)-derived innate immunocompetent 3D CNS model that recapitulates…
Shaurav Bhattarai, Emma G. Foster, Rana Kadry, Yaman Lu + 9 more
In contrast, astrocyte responses, measured as the percentage of GFAP-positive area, did not differ significantly among the groups in either the hippocampus or cortex (Figure [alz71807-fig-0003]). However, HIV-1-infected hNAIL mice exhibited a non-significant trend toward an increase in GFAP staining compared to other…
Spyros Thivaios, Jochen Schwenk, Aline Brechet, Sami Boudkkazi + 16 more
Synapses, prototypic sites for neuronal communication, are key to brain function. Their organization and properties are instructed by synaptic cell adhesion molecules (sCAMs) that may operate independently or in coordination through yet unknown linker proteins. Here, we used multi-epitope affinity-purifications…