10 papers · ranked by Valyu relevance
Nishant Sinha, Yujiang Wang, Nádia Moreira da Silva, Anna Miserocchi + 6 more
We assessed pre-operative structural brain networks and clinical characteristics of patients with drug resistant temporal lobe epilepsy (TLE) to identify correlates of post-surgical seizure outcome at 1 year and seizure relapses up to 5 years. We retrospectively examined data from 51 TLE patients who underwent anterior…
Amaia Ochandorena-Saa, Emeline Perthame, Zoé Oulerich, Alexander Chamolly + 5 more
Left-right symmetry breaking in mice is considered to occur via node leftward fluid flow. The molecular cascade within the node has been reconstructed at high resolution. However, its importance for organogenesis remains poorly understood. Here we show in mutants for the motile cilium component CCDC40 that 70% of mice…
Mohamed Radwan, Pedro G. Lind, Anis Yazidi
In this study, we investigate the use of temporal dynamics in brain connectivity for the classification of electroencephalography (EEG) signals using dynamic Graph Neural Networks (GNNs). Our methods are applied to several large-scale EEG datasets focused on abnormality and epilepsy detection. The implemented models…
Yonghe Ding, Di Lang, Jianhua Yan, Haisong Bu + 11 more
Sick sinus syndrome (SSS) is a group of heart rhythm disorders caused by malfunction of the sinus node, the heart’s primary pacemaker. Partially owing to its aging-associated phenotypic manifestation and low expressivity, molecular mechanisms of SSS remain difficult to decipher. Here, we aim to develop a…
Cole Korponay, Elliot A Stein, Thomas J Ross
Corticostriatal circuits are central to reward processing and reinforcement learning functions that often become dysregulated in substance use disorder (SUD) and drive compulsive drug use. Human neuroimaging research seeking to identify how corticostriatal circuits become altered in SUD has primarily focused on…
Francis Normand, Mehul Gajwani, Daniel C. Côté, Antoine Allard
Elucidating the coupling between the structure and the function of the brain and its development across maturation has attracted a lot of interest in the field of network neuroscience in the last fifteen years. Mounting evidence support the hypothesis that the onset of certain brain disorders is linked with the…
Nima Rafiee, Rahil Gholamipoor, Markus Kollmann
Recent progress in computer-aided technologies has had a considerable impact on helping experts with a reliable and fast diagnosis of abnormal samples. In particular, self-supervised and self-distillation techniques have advanced automated out-of-distribution (OOD) detection in the image domain. Further improvements in…
Tobias Holm Bønnelykke, Marie-Amandine Chabry, Emeline Perthame, Audrey Desgrange + 1 more
The TGFβ secreted factor NODAL is a major left determinant required for the asymmetric morphogenesis of visceral organs, including the heart. Yet, when this signalling is absent, shape asymmetry, for example of the embryonic heart loop, is not fully abrogated, indicating that there are other factors regulating…
Abu Nahia Karim, Migdał Maciej, Quinn T. Alexander, Poon Kar-Lai + 9 more
The atrioventricular canal (AVC) is an essential feature of the heart, which separates the atrium from the ventricle. During heart morphogenesis, it is a hub of molecular processes necessary for distinguishing heart regions; most importantly, for the formation of the AV conduction system and cardiac valves. To better…
Helen M. Phillips, Catherine A. Stothard, Wasay Mohiuddin Shaikh Qureshi, Anastasia I. Kousa + 15 more
Developmental defects affecting the heart and aortic arch arteries are a key phenotype observed in DiGeorge syndrome patients and are caused by a microdeletion on chromosome 22q11. Heterozygosity of TBX1, one of the deleted genes, is expressed throughout the pharyngeal arches and is considered a key component for the…