12 papers · ranked by Valyu relevance
Maddalena M Bolognesi, Lorenzo Dall’Olio, Giulio Eugenio Mandelli, Luisa Lorenzi + 7 more
Lymph nodes (LN) are key secondary lymphoid organs (SLO) for a coordinated immune response. They have been extensively characterized by numerous investigative techniques chiefly as single cell suspensions because they are composed of vagile yet crowded hematolymphoid elements, unfriendly to spatial tissue…
Guangyu Wang, Limei Zhang, Lishan Qiao
Brain functional network (BFN) analysis has become a popular technique for identifying neurological/mental diseases. Due to the fact that BFN is a graph, graph convolutional network (GCN) can be naturally used in the classification of BFN. Different from traditional methods that directly use the adjacency matrices of…
Lida Kanari, Stanislav Schmidt, Francesco Casalegno, Emilie Delattre + 7 more
The shape of neuronal morphologies plays a critical role in determining their dynamical properties and the functionality of the brain. With an abundance of neuronal morphology reconstructions, a robust definition of cell types is important to understand their role in brain functionality. However, an objective…
Vladimir Belov, Vladislav Kozyrev, Aditya Singh, Matthew D. Sacchet + 1 more
Repetitive transcranial magnetic stimulation (rTMS) has gained considerable importance in the treatment of disorders, e.g. depression. However, it is not yet understood how rTMS alters brain’s functional connectivity. Here we report the changes captured by resting state functional magnetic resonance imaging (rsfMRI)…
Henri Riihimäki, Wojciech Chachólski, Jakob Theorell, Jan Hillert + 1 more
Machine learning models for repeated measurements are limited. Using topological data analysis (TDA), we present a classifier for repeated measurements which samples from the data space and builds a network graph based on the data topology. When applying this to two case studies, accuracy exceeds alternative models…
Jiyoung Byun, Yong Jeong
Deep learning frameworks for disease classification using neuroimaging and non-imaging information require the capability of capturing individual features as well as associative information among subjects. Graphs represent the interactions among nodes, which contain the individual features, through the edges in order…
Luca Cappelletti, Lauren Rekerle, Tommaso Fontana, Peter Hansen + 13 more
Graph representation learning is a family of related approaches that learn low-dimensional vector representations of nodes and other graph elements called embeddings. Embeddings approximate characteristics of the graph and can be used for a variety of machine-learning tasks such as novel edge prediction. For many…
Renming Liu, Matthew Hirn, Arjun Krishnan
Accurately representing biological networks in a low-dimensional space, also known as network embedding, is a critical step in network-based machine learning and is carried out widely using node2vec, an unsupervised method based on biased random walks. However, while many networks, including functional gene interaction…
Tetsu Sakamoto, J. Miguel Ortega
NCBI Taxonomy is the main taxonomic source for several bioinformatics tools and databases since all organisms with sequence accessions deposited on INSDC are organized in its hierarchical structure. Despite the extensive use and application of this data source, taking advantage of its taxonomic tree could be…
Qingxuan Song, Sofia D Merajver, Jun Z. Li
Classification is an everyday instinct as well as a full-fledged scientific discipline. Throughout the history of medicine, disease classification is central to how we develop knowledge, make diagnosis, and assign treatment. Here we discuss the classification of cancer, the process of categorizing cancer subtypes based…
Paul Kruse, Caroline Ring
This paper presents the treecompareR package for R, which provides tools for reproducible visualizations of data through the use of taxonomies. The package builds on developments from ggplot2 and ggtree to provide visualizations tailored for use with taxonomic classification data. Additionally, it provides tools that…
Fei Deng, Jibing Huang, Xiaoling Yuan, Chao Cheng + 1 more
Most of the biomedical datasets, including those of ‘omics, population studies and surveys, are rectangular in shape and have few missing data. Recently, their sample sizes have grown significantly. Rigorous analyses on these large datasets demand considerably more efficient and more accurate algorithms. Machine…