4 papers · ranked by Valyu relevance
Danny Vu, Andrew Kowalczewski, Sarah D. Burnett, Courtney Sakolish + 4 more
Cardiotoxicity remains a major cause of drug attrition and postmarket withdrawal, yet the vast majority of environmental chemicals to which humans may be exposed remain uncharacterized for cardiotoxicity risk. Human induced pluripotent stem cell (hiPSC)-based testing has been proposed to address this gap. Here, we…
John Tower
Biological information is generally thought to be subject to selection for faithful maintenance. However, accurate preservation is often combined with regulated mechanisms that generate state change. Selectively advantageous instability (SAI) is modeled here as instability that is favored because useful alternatives…
Yi Ren, Zimei Chen, Hayden Deans, Ying Nian Wu + 1 more
Extensive studies suggest the brain performs Bayesian inference to infer the latent world states. It is a fundamental neuroscience question that how canonical recurrent neural circuits in the brain implement Bayesian inference. Many existing theoretical studies focused on how the recurrent circuits compute the…
Alexander Aichmair, Heiko Graichen, Nimrod Snir, Benjamin V. Bloch + 4 more
Total knee arthroplasty (TKA) is a highly successful procedure for the treatment of end-stage osteoarthritis of the knee . While mechanical alignment has been considered the gold standard for decades , personalized alignment strategies have been established with the aim of improving postoperative patient satisfaction…