11 papers · ranked by Valyu relevance
Jahnavi Bhaskaran, Elizabeth Ing-Simmons, Irina Balaguer Balsells, Sara Di Persio + 11 more
Gametogenesis, the production of oocytes and sperm, ensures the faithful transmission of genetic material to the next generation. In males, spermatogenesis occurs within the testis, where germ cells progress through a highly ordered developmental programme in close association with supporting somatic cells. Defects in…
Atif Khan, Sruti Chandramouli, Hiren M. Joshi
The crystal violet (CV) microtiter plate assay is widely used to compare microbial biofilm formation because it is inexpensive, simple, and readily adapted to 96-well formats. Its high-throughput design enables multiple strains, growth conditions, and treatments to be tested in parallel, but increasing experimental…
Yi Ren, Zimei Chen, Hayden Deans, Ying Nian Wu + 1 more
Extensive studies suggest the brain performs Bayesian inference to infer the latent world states. It is a fundamental neuroscience question that how canonical recurrent neural circuits in the brain implement Bayesian inference. Many existing theoretical studies focused on how the recurrent circuits compute the…
Theresa Kolb, Friederike Ingrid Tam, Claudia Förster Ribet, Michaela Ohme + 8 more
Background Glucagon-like peptide-1 (GLP-1), gastric inhibitory peptide (GIP), glucagon, and glicentin are gastrointestinal hormones derived from proglucagon that play crucial roles in regulating appetite and glucose homeostasis. These hormones have been examined during the acute state of anorexia nervosa (AN), with our…
Md Shafayet Hossain, Yi-Ping Phoebe Chen
Non-coding RNAs (ncRNAs), once considered genomic dark matter, are now established as key regulators of gene expression with widespread roles in cellular homeostasis and disease. In cancer, ncRNA expression is frequently and systematically dysregulated, and many of these molecules circulate in stable, protected form…
Justina Stark, Christophe Godin
Biological transport networks range from tree-like to highly reticulated architectures, which have been proposed to reflect different balances between viscous dissipation and metabolic cost. This balance cannot currently be inferred from structure: available descriptors either discard edge width entirely or preserve it…
Alexander Muacevic, John R Adler, Ei Ei Phyo Naing, Mouli Nandi + 2 more
Background: Umbilical artery Doppler (UAD) is widely used to assess placental function in pregnancies complicated by fetal growth restriction (FGR), but the clinical significance of an abnormal UAD in a fetus that is normally grown at the time of diagnosis is less certain. This study describes the subsequent Doppler…
Rosángela López-Mena, Carolina Rojas-Cruz, Fernando Ruiz-Magaña, Eduardo I. Arteaga-Chan + 1 more
After exclusion of alternative etiologies, the clinical presentation was considered most consistent with IIH manifesting as an atypical cranial polyneuropathy involving cranial nerves VII and VIII. Although abducens nerve palsy is a recognized false-localizing sign of raised intracranial pressure, simultaneous facial…
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood + 20 more
Identifying new genes responsible for non-syndromic hearing loss remains a critical goal as many patients still lack a molecular diagnosis despite comprehensive genetic testing. The tectorial membrane (TM) is a specialized acellular matrix of the inner ear, essential for stimulating mechanosensitive hair cell…
Peter F. Pelz, Tobias Meck
For nearly a century, the physical origin of metabolic scaling has remained unresolved: metabolism is proportional to body mass in small organisms but follows Kleiber’s three-quarter-power law in larger animals. We derive both regimes from the Metabolic Holon (MH), a locally optimized capillary–tissue oxygen-supply…
Edouard Guez, Theodore Falempin, Cyril Hanin, Alison Arbouche + 7 more
Children with autism may develop acute or subacute behavioral deterioration, catatonic deterioration from baseline, or severe externalizing symptoms that risk being attributed solely to autism. Autism involves persistent social-communication difficulties and restricted/repetitive behaviors, including stereotyped…