7 papers · ranked by Valyu relevance
Rajorshi Paul, Kevin S. Zhang, Myra Kurosu Jalil, Nicolas Castaño + 2 more
Stentor coeruleus, a single-cell ciliated protozoan, is a model organism for wound healing and regeneration studies. Despite Stentor’s large size (up to 2 mm in extended state), microdissection of Stentor remains challenging. In this work, we describe a hydrodynamic cell splitter, consisting of a cross junction…
Ray Zirui Zhang, Christopher E. Miles, Xiaohui Xie, John S. Lowengrub
We propose a new neural network based method for solving inverse problems for partial differential equations (PDEs) by formulating the PDE inverse problem as a bilevel optimization problem. At the upper level, we minimize the data loss with respect to the PDE parameters. At the lower level, we train a neural network to…
Florian Privé
A few algorithms have been developed for splitting the genome in nearly independent blocks of linkage disequilibrium. Due to the complexity of this problem, these algorithms rely on heuristics, which makes them sub-optimal. Here we develop an optimal solution for this problem using dynamic programming. This is now…
Roman Joeres, David B. Blumenthal, Olga V. Kalinina
Information Leakage is an increasing problem in machine learning research. It is a common practice to report models with benchmarks, comparing them to the state-of-the-art performance on the test splits of datasets. If two or more dataset splits contain identical or highly similar samples, a model risks simply…
Kangbien Park, Yonghee Bae
Drift, selection, and mutation are integral evolutionary factors. In this article, operator model is newly suggested to intuitively represent those evolutionary factors into mathematical operators, and to ultimately offer unconventional methodology for understanding evolutionary dynamics. To be specific, each of the…
Shaked Tayouri, Vladislav Kogan, Jacob Beal, Tal Levy + 7 more
Biosecurity screening of synthetic DNA orders is a key defense against malicious actors and careless enthusiasts producing dangerous pathogens or toxins. It is important to evaluate biosecurity screening tools for potential vulnerabilities and to work responsibly with providers to ensure that vulnerabilities can be…
Delaney K. Sullivan, Lior Pachter
Next-generation sequencing libraries are constructed with numerous synthetic constructs such as sequencing adapters, barcodes, and unique molecular identifiers. Such sequences can be essential for interpreting results of sequencing assays, and when they contain information pertinent to an experiment, they must be…