11 papers · ranked by Valyu relevance
Odin Zhang, Jiaqi Wang, Tuscan Rock Thompson, Ziyi You + 3 more
Biomolecular interactions, including protein–protein interactions, protein–nucleic acid recognition, and protein–small molecule binding, underlie a wide range of biological processes and therapeutic mechanisms. Although recent de novo design methods can generate candidate binders for diverse molecular targets…
Yuesong Wu, Haohao Su, Yuehua Cui
Cell-cell communication (CCC) is essential for maintaining tissue organization and driving biological progression, yet its inference from transcriptomic data has long been limited by the absence of spatial context. Advances in spatial transcriptomics (ST) now enable mechanistically grounded analyses of CCC by…
Kunyu Wang, Jon Paul Janet, Alessandro Tibo
Three-dimensional molecular generative models have emerged that produce de novo molecules both unconditionally and conditionally, e.g., within protein pockets. However, steering those models in a specific region of the chemical space that satisfies a set of desired properties remains challenging. In this study, we…
Junjie Yao, Zhongxu Li, Cuiping Wang, Junyu Wu + 3 more
A motion control strategy based on multi-source heterogeneous motion information fusion and motion decoupling parallel washout algorithm (WA) is proposed for the control of a rehabilitation robot designed for stroke-related balance disorders. The robot features a serial-parallel hybrid structure and humanoid gait…
Peter F. Pelz, Tobias Meck
For nearly a century, the physical origin of metabolic scaling has remained unresolved: metabolism is proportional to body mass in small organisms but follows Kleiber’s three-quarter-power law in larger animals. We derive both regimes from the Metabolic Holon (MH), a locally optimized capillary–tissue oxygen-supply…
Ella Wilczynski, Kulam Najmudeen Magdoom, Alexandru V Avram, Nathan H Williamson + 3 more
To demonstrate the feasibility of whole-brain multidimensional T_1_-T_2_ relaxation imaging on a portable 0.064 T MRI scanner. A two-dimensional inversion-recovery, fast spin-echo acquisition was used to jointly encode T_1_ and T_2_ relaxation. Joint relaxation distributions were reconstructed voxel-wise using…
Alp Tartici, Mihajlo Stojkovic, Anru Tian, Michael C. Jewett + 2 more
Protein engineering has important implications in the bioeconomy, enabling applications in materials, medicine, and energy. A key challenge is designing protein sequences that have a specific form and function. Protein inverse folding seeks to address this challenge by identifying amino acid sequences compatible with a…
Wei-shan Li, Gregory P. Way
Pairing label-free microscopy with virtual staining could reduce the cost and experimental burden of fluorescence microscopy, but its impact is conditional on generalizable inference. Most virtual staining studies assess performance using image quality assessment (IQA) metrics developed for natural images, yet how well…
Sahar Alkhaibari, Feng Dong
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by persistent difficulties in social communication, social interaction, and repetitive behaviors. Early and accurate diagnosis is essential but is often hindered by subjective clinical assessments, limited data availability, and…
Mohamed Selmy, A. Abdulnabi, A. A. Ali, E. M. Saied + 1 more
Nanogrids have emerged as a crucial solution for contemporary residential power systems, providing a robust framework for integrating distributed energy resources (DERs), comprising solar photovoltaics (PVs), wind turbines (WTs), energy storage systems (ESSs), and diesel generators (DGs). However, the uncertainty of…
Patrick D. Fischer, Sebastian Hiller
“Undruggable” proteins without surface-accessible binding sites pose significant challenges to target-based drug discovery. Innovative approaches are needed to tackle these proteins. One promising strategy is targeting them in their nascent chain form at the ribosome, where they have a different conformation than in…