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Search · four archives
11 papers · ranked by Valyu relevance
Aleksandr Fedorov, Anna Perechodjuk, David Linke
Artificial neural networks (ANNs) are powerful tools for solving a wide range of tasks in fundamental and applied science. However, training and building reliable ANN models requires a lot of data which so far hinders their wider application in kinetic modelling where typically only small (experimental) datasets are…
Authors not listed
This paper presents the Multi Cell-line Kinetic Model (MCKM), a novel generalised kinetic mechanistic model specifically tailored for Ambr15™ fed-batch cultivations of multiple Chinese Hamster Ovary (CHO) cell lines producing different recombinant monoclonal antibodies (mAbs). Unlike traditional models that requires…
harry gray
The matrix exponential method as implemented in MATLAB is demonstrated as a facile tool for solving the time-dependent concentrations of an arbitrary chemically reactive network modelled as a coupled linear system of first-order differential equations. The method is used to verify a 10 species network incorporating…
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Alternating current voltammetry (ACV) is gaining popularity for its ability to improve the yield of electrochemical syntheses, and for its ability to improve the sensitivity of electroanalytical measurements. Chief among the analytical advantages of ACV is its ability to generate an alternating current at integer…
Justin Eilertsen, Wylie Stroberg, Santiago Schnell
A theoretical analysis is performed on the nonlinear ordinary differential equations that govern the dynamics of a coupled enzyme catalyzed reaction. The assay consists of a non-observable reaction and an indicator (observable) reaction, where the product of the first reaction is the enzyme for the second. Both…
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Real-world datasets in chemical engineering and bioengineering processes--such as those from catalytic reactors, multiphase flows, polymerization reactors, bioreactors, and clinical trials--can often be unlabelled or disorganized, rendering the training of existing supervised learning models ineffective at learning the…
Yoshiharu Mukouyama, Kenya Tanaka, Shuji Nakanishi, Yoshihiro Nakato
The present work reveals that a prebiotic chemical system can generate self-organizing ability that leads to highly ordered structures and an active character such as free independent harmonious behavior. This result is the properties of natural things that have long been overlooked since Darwin’s theory of evolution…
Harry Gray
Developed in this article is the electron transfer network, a graph structure whose adjacent nodes are reversibly coupled chemically reactive species whose forward and reverse rate constants are calculated by semiclassical electron transfer theory. These ET networks resemble electric circuits containing branches…
Authors not listed
Deriving versatile and robust mechanistic models from experimental data is a key challenge in engineering and natural sciences. This is especially true in chemical reaction engineering, where reactor manufacturers and operators increasingly pursue the development and maintenance of digital twins that rely on frequent…
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A method has been introduced to derive the solution of the time-independent Schrodinger equation for the simple harmonic oscillator. A trial solution has been chosen as the product of the divergent part of the approximate asymptomatic solution of the Schrodinger equation and an unknown function. By inserting this trial…
Justin Eilertsen, Wylie Stroberg, Santiago Schnell
The determination of a substrate or enzyme activity by coupling of one enzymatic reaction with another easily detectable (indicator) reaction is a common practice in the biochemical sciences. Usually, the kinetics of enzyme reactions is simplified with singular perturbation analysis to derive rate or time course…