8 papers · ranked by Valyu relevance
Ziareena Al-Mualem, Xiaobing Chen, Joseph Shirley, Cong Xu + 1 more
BoxCARS and pump-probe geometries are common implementations of two dimensional infrared (2D IR) spectroscopy. BoxCARS is background-free, generally offering greater signal to noise ratio, which enables measuring weak vibrational echo signals. Pulse shapers have been implemented in the pump probe geometry to accelerate…
Lev Levintov, Biswajit Gorai, Harish Vashisth
The insulin receptor (IR) and the insulin-like growth factor-1 receptor (IGF1R) are homodimeric transmembrane glycoproteins that transduce signals across the membrane on binding of extracellular peptide ligands. The structures of IR/IGF1R fragments in apo and liganded states have revealed that the extracellular…
G. Kandemir, D. H. Duncan, D. van Moorselaar, J. Theeuwes
For almost half a century, target-distractor similarity has been known to induce different visual search modes. When a target is highly salient, it can pop out, suggesting parallel processing of all items irrespective of set size. By contrast, high similarity among items requires item-by-item comparison with an…
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With the ever-increasing demand for atomistic structures representative of real-life systems as well as the ad-vent of exascale computers, it has now become necessary and possible to use advanced global optimization (GO) techniques to intelligently sample the potential energy surface (PES). Given the previous studies…
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Protein conformational landscapes contain the functionally relevant information useful for understanding biological processes. Mapping out conformational landscapes provides valuable insights into protein behaviors and biological phenomena, and has relevance to therapeutic design. While experimental structural biology…
Jichao Ma, Duyen Nguyen, Jazune Madas, Ariege Bizanti + 12 more
Nociceptive afferent axons innervate the stomach and send signals to the brain and spinal cord. Peripheral nociceptive afferents can be detected with a variety of markers [e.g., substance P (SP) and calcitonin gene-related peptide (CGRP)]. We recently examined the topographical organization and morphology of…
Jingke Hou, Sabine Chevallier-Michaud, Marion Jean, Luc Favre + 2 more
Accessing each enantiomers of a chiral molecule starting from a racemic mixture remains a daunting challenge in chemistry. Indeed, until now only few solutions exist to separate enantiomers of an equimolar mixture of a chiral precursor. In this study, we establish a new strategy to prepare simultaneously and physically…
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Metal nanoclusters (NCs) with a particle size of approximately 1 nm exhibit potential as highly active catalysts owing to their large specific surface areas and unique electronic structures. However, their precise synthesis in air is predominantly limited to coinage metal (Cu, Ag, and Au) NCs. Consequently, the…