11 papers · ranked by Valyu relevance
Unitsa Sangket, Surakameth Mahasirimongkol, Wasun Chantratita, Pichaya Tandayya + 1 more
'Pichaya Tandayya' 'Yurii S Aulchenko'] Background Genome-Wide Association (GWA) analysis is a powerful method for identifying loci associated with complex traits and drug response. Parts of GWA analyses, especially those involving thousands of individuals and consuming hours to months, will benefit from parallel…
Timothy A. Pitman, Xiaomeng Huang, Gabor T. Marth, Yi Qiao
In precision medicine, genomic data needs to be processed as fast as possible to arrive at treatment decisions in a timely fashion. We developed mmbam, a library to allow sequence analysis informatics software to access raw sequencing data stored in BAM files extremely fast. Taking advantage of memory mapped file…
Francois Besnier, Kevin A. Glover, Maria Anisimova
This software package provides an R-based framework to make use of multi-core computers when running analyses in the population genetics program STRUCTURE. It is especially addressed to those users of STRUCTURE dealing with numerous and repeated data analyses, and who could take advantage of an efficient script to…
Julia L Turner, Scott T Kelley, James S Otto, Faramarz Valafar + 1 more
'Andrew J Bohonak'] Background The Isolation by Distance Web Service (IBDWS) is a user-friendly web interface for analyzing patterns of isolation by distance in population genetic data. IBDWS enables researchers to perform a variety of statistical tests such as Mantel tests and reduced major axis regression (RMA), and…
G.R. van der Ploeg, J.A. Westerhuis, A. Heintz-Buschart, A.K. Smilde
Recently, studies that investigate microbial temporal dynamics have become more frequent. In a longitudinal microbiome study design, microbial abundance data are collected across multiple time points from the same subjects. In this context, exploratory analysis of longitudinal microbiome data using Principal Component…
Alessandro Petrini, Marco Mesiti, Max Schubach, Marco Frasca + 7 more
The idea on which multi-core parSMURF builds is that all operations performed on the different parts of the partition can be assigned to multiple core/threads and processed in parallel. Namely, given q threads, the data parts N1, …, Nn are equally distributed among threads so that thread i receives a subset (chunk) Ci…
Zeyu Xia, Canqun Yang, Chenchen Peng, Yifei Guo + 3 more
'Tao Tang' 'Yingbo Cui'] Background The advent of Single Molecule Real-Time (SMRT) sequencing has overcome many limitations of second-generation sequencing, such as limited read lengths, PCR amplification biases. However, longer reads increase data volume exponentially and high error rates make many existing alignment…
S. Katharina Schmitz, Philipp P. Hasselbach, Boris Ebisch, Anja Klein + 2 more
'Anja Klein' 'Gordon Pipa' 'Ralf A. W. Galuske'] The identification of important features in multi-electrode recordings requires the decomposition of data in order to disclose relevant features and to offer a clear graphical representation. This can be a demanding task. Parallel Factor Analysis (PARAFAC; Hitchcock…
Hüsser Alejandra, Caron-Desrochers Laura, Tremblay Julie, Vannasing Phetsamone + 2 more
Functional near infrared spectroscopy (fNIRS) is a neuroimaging technique that uses light at two different wavelengths in the near infrared spectrum to estimate cerebral hemodynamic response, based on concentration changes in both oxygenated and deoxygenated hemoglobin. A multi-dimensional decomposition technique…
Kecong Tang, Ahsan Sanaullah, Degui Zhi, Shaojie Zhang
Durbin’s positional Burrows-Wheeler transform (PBWT) enables algorithms with the optimal time complexity of O(MN) for reporting all vs all haplotype matches in a population panel with M haplotypes and N variant sites. However, even this efficiency may still be too slow when the number of haplotypes reaches millions. To…
Ben Langmead, Christopher Wilks, Valentin Antonescu, Rone Charles
General-purpose processors can now contain many dozens of processor cores and support hundreds of simultaneous threads of execution. To make best use of these threads, genomics software must contend with new and subtle computer architecture issues. We discuss some of these and propose methods for improving thread…