9 papers · ranked by Valyu relevance
Yiming Xue, Xiaojian Liu, Weimin Zhu, Shengfan Wang + 2 more
While protein-RNA interactions are fundamental to post-transcriptional processes, achieving a holistic understanding of their regulatory logic remains challenging. Current computational models often treat binding affinity, interface mapping, and RNA design as isolated tasks, thereby failing to provide a unified…
Junjie Yao, Zhongxu Li, Cuiping Wang, Junyu Wu + 3 more
A motion control strategy based on multi-source heterogeneous motion information fusion and motion decoupling parallel washout algorithm (WA) is proposed for the control of a rehabilitation robot designed for stroke-related balance disorders. The robot features a serial-parallel hybrid structure and humanoid gait…
Julie Boisard, Shelby K Williams, Andrew J Roger, Courtney W Stairs
Mitochondrial proteome reconstruction from eukaryotic sequence data typically relies on prediction of mitochondrial targeting signals (MTSs). However, MTS predictors are primarily trained on model organisms and may perform poorly in phylogenetically divergent lineages or in organisms with atypical or reduced targeting…
Himanshu Goel, Miklos Sahin -Toth
Current transcriptomic resources provide increasingly detailed information about transcript expression, exon utilisation, developmental regulation and molecular consequence. TRACE is designed to organise how this information is escalated and documented when it is material to interpretation. It does not create new…
Ana Lúcia Leitão, Francisco J Enguita
The evolution of molecular visualization software represents a pivotal yet often underappreciated dimension of computational structural biology and bioinformatics. As the scale and complexity of structural datasets increase, spanning from cryo-electron microscopy reconstructions to proteome-wide AI-predicted models…
Yonatan Amzaleg, Kevin J. McDonnell, Gregory E. Idos, Christina Mathai + 4 more
Variants of uncertain significance (VUS) in mismatch repair (MMR) genes represent a persistent bottleneck in germline interpretation for Lynch syndrome, creating a critical opportunity to leverage tumor biology to refine pathogenicity assessment. Although tumor features such as microsatellite instability (MSI) and…
Yuesong Wu, Haohao Su, Yuehua Cui
Cell-cell communication (CCC) is essential for maintaining tissue organization and driving biological progression, yet its inference from transcriptomic data has long been limited by the absence of spatial context. Advances in spatial transcriptomics (ST) now enable mechanistically grounded analyses of CCC by…
Feng Zhou, Jia-Bin Zhou, Yi-Qing Yan, Tian-Peng Wei + 4 more
Ferritin heavy Chain 1 (FTH1) is a key protective factor against ferroptosis in the heart, yet its protein abundance can diverge from transcript levels in cardiac ferroptosis contexts. Since resistance to ferroptosis depends on FTH1 protein abundance rather than transcript levels and its ferroxidase activity cannot be…
Charles de Kergariou, Helmut Hauser, David Correa
Advances in novel materials science enable structures to function as intelligent machines by embedding memory and learning capabilities directly into materials. Our work introduces a physical adaptive material motor unit neural network, leveraging a new generation of controllable actuators composed of wood- and carbon…