13 papers · ranked by Valyu relevance
Yanhui Hu, Ben Ewen-Campen, Aram Comjean, Jonathan Rodiger + 2 more
'Stephanie E. Mohr' 'Norbert Perrimon'] Title: Graphical abstract
Domenico Di Fraia, Mihaela Anitei, Marie-Therese Mackmull, Luca Parca + 7 more
'Luca Parca' 'Laura Behrendt' 'Amparo Andres-Pons' 'Darren Gilmour' 'Manuela Helmer Citterich' 'Christoph Kaether' 'Martin Beck' 'Alessandro Ori\u202c\u202c'] Paralog proteins promote fine tuning of protein complexes. The author identified a specific paralog signature conserved across vertebrate neuronal…
Tamar Gera, Felix Jonas, Roye More, Naama Barkai + 2 more
'Christian R Landry' 'Kevin Struhl'] Throughout evolution, new transcription factors (TFs) emerge by gene duplication, promoting growth and rewiring of transcriptional networks. How TF duplicates diverge was studied in a few cases only. To provide a genome-scale view, we considered the set of budding yeast TFs…
Yibo Si, Kshitiz Adhikari, Laura E. Herring, Daniel Isom + 6 more
Paralogs engage in biological processes through both redundant and non-redundant functions. In the yeast Saccharomyces cerevisiae, approximately one-fifth of the genome consists of paralogs, with their encoded proteins involved in multiple pathways. However, the unique contributions of individual paralogs have remained…
Yucui Xin, Yingsheng Zhang
Tumor cells can result from gene mutations and over-expression. Synthetic lethality (SL) offers a desirable setting where cancer cells bearing one mutated gene of an SL gene pair can be specifically targeted by disrupting the function of the other genes, while leaving wide-type normal cells unharmed. Paralogs, a set of…
Olivier Dennler, Colm J Ryan
Gene duplication is the primary source of new genes, resulting in most genes having identifiable paralogs. Over time, paralog pairs may diverge in some respects but many retain the ability to perform the same functional role. Protein sequence identity is often used as a proxy for functional similarity and can predict…
Brittany M Greco, Gerardo Zapata, Rohan Dandage, Mikhail Papkov + 6 more
'Vanessa Pereira' 'François Lefebvre' 'Guillaume Bourque' 'Leopold Parts' 'Elena Kuzmin' 'G Brown'] Title: Abstract Whole-genome duplication (WGD) events are common across various organisms; however, the retention and evolution of WGD paralogs is not fully understood. Quantitative measure of protein redistribution in…
Rohan Dandage, Mikhail Papkov, Brittany M. Greco, Dmytro Fishman + 9 more
'Helena Friesen' 'Kyle Wang' 'Erin Styles' 'Oren Kraus' 'Benjamin Grys' 'Charles Boone' 'Brenda Andrews' 'Leopold Parts' 'Elena Kuzmin'] Gene duplication is common across the tree of life, including yeast and humans, and contributes to genomic robustness. In this study, we examined changes in the subcellular…
Adele Francis Xu, Rut Molinuevo, Elisa Fazzari, Harrison Tom + 9 more
'Zijian Zhang' 'Julien Menendez' 'Kerriann M Casey' 'Davide Ruggero' 'Lindsay Hinck' 'Jonathan K Pritchard' 'Maria Barna' 'Shigehiro Kuraku' 'George H Perry'] The formation of paralogs through gene duplication is a core evolutionary process. For paralogs that encode components of protein complexes such as the ribosome…
Barbara De Kegel, Colm J Ryan
Genomic instability is a hallmark of cancer, resulting in tumor genomes having large numbers of genetic aberrations, including homozygous deletions of protein coding genes. That tumor cells remain viable in the presence of such gene loss suggests high robustness to genetic perturbation. In model organisms and cancer…
Rohan Dandage, Mikhail Papkov, Brittany M. Greco, Vanessa Pereira + 13 more
'Dmytro Fishman' 'Helena Friesen' 'Kyle Wang' 'Erin B. Styles' 'Oren Kraus' 'Benjamin Grys' 'Gerardo Zapata' 'Francois Lefebvre' 'Guillaume Bourque' 'Charles Boone' 'Brenda J. Andrews' 'Leopold Parts' 'Elena Kuzmin'] Title: Summary Gene duplication is common across the Tree of Life and contributes to genomic…
Evgeny Fraimovitch, Tzachi Hagai
Background Gene duplication is thought to be a central process in evolution to gain new functions. The factors that dictate gene retention following duplication as well paralog gene divergence in sequence, expression and function have been extensively studied. However, relatively little is known about the evolution of…
Juan M. Escorcia-Rodríguez, Mario Esposito, Julio A. Freyre-González, Gabriel Moreno-Hagelsieb + 1 more
'Gabriel Moreno-Hagelsieb' 'Joseph Gillespie'] Orthologs separate after lineages split from each other and paralogs after gene duplications. Thus, orthologs are expected to remain more functionally coherent across lineages, while paralogs have been proposed as a source of new functions. Because protein functional…