6 papers · ranked by Valyu relevance
Rajarshi Sarkar
This case report discusses how paraproteins interfere with multiple chemistry analyses and protocols to overcome such obstacles. A serum specimen containing two monoclonal IgA (llight chain) paraproteins is subjected to a battery of tests on three wet chemistry platforms - AU5800, Cobas Pure, and Alinityci; the results…
Sheng Wang, Xiaoyong Duan, Yulin Zou, Jianxiong Gui
Title: Graphical abstract
Xin Tian, Li Zhao, Jin Ma, Jie Lu + 3 more
Paraproteins are monoclonal immunoglobulins (Igs) or immunoglobulin fractions present in the blood or urine produced by a clonal population of B-cell lineage cells, most commonly plasma cells. The presence of paraproteins may signify a variety of underlying conditions, ranging from a benign process known as monoclonal…
Laia Oliveras, Ana Coloma, Teresa Escartín, Maria José Castro + 3 more
1## Introduction Paraproteins can interfere with various analysis methods by increasing turbidity or precipitation, leading to an erroneous measurement (1, 2). The Jaffe and enzymatic methods are the most common for measuring serum creatinine. Jaffe method is based on the reaction of creatinine with picric acid, and…
Mahsa Dabir, Maryam Kamrani Mousavi, Mohana Mohamadi, Ali Maleki
1## Introduction Multiple myeloma is an incurable hematological malignancy characterized by uncontrolled growth of monoclonal plasma cells in the bone marrow that leads to the overproduction of immunoglobulin chains . Paraproteins are abnormal immunoglobulins produced in excess by malignant plasma cells in multiple…
Svenja F. B. J. Mennens, Ellen Van der Spek, Janneke Ruinemans-Koerts, Marcel M. G. J. Van Borren
'Marcel M. G. J. Van Borren'] We present a patient at risk of misdiagnosis with multiple myeloma due to pseudohypercalcemia. Examinations showed monoclonal protein, 50% monoclonal plasma cells in bone marrow, and hypercalcemia but no osteolytic bone lesions. Follow-up tests revealed pseudohypercalcemia, with elevated…