10 papers · ranked by Valyu relevance
Florian Köhler, Anna Delgado-Tejedor, Maik Zehnsdorf, Marisol Salgado Albarran + 5 more
Short-read sequencing-based single-cell transcriptomics represents the current gold standard for studying cellular transcriptomes but remains limited in its ability to resolve full-length transcript isoforms and splicing patterns. Long-read single-cell and single-nucleus RNA sequencing (LR sc/snRNA-seq) enables the…
Jeremy Yuan-Sheng Leow, Nancy Choon-Si Ng, Rebecca Shin-Yee Wong, Long Chiau Ming + 2 more
Ovarian cancer (OC) remains difficult to detect at an early stage, and current screening approaches using CA125 and transvaginal ultrasonography have not demonstrated sufficient benefit for population screening. DNA methylation is a promising biomarker class because epigenetic alterations may arise early in…
Sum Yi Cheong, Trevors In Zen Liew, Chee Kin Wong, Xue Xin Teng + 4 more
Lung-on-a-chip (LoAC) technology has emerged as a human-relevant microphysiological approach for respiratory disease modelling and preclinical drug evaluation. However, substantial variation in device architecture, membrane properties, fluidic conditions, mechanical actuation, cellular composition, sensing and…
Jalaja Madhusudhanan, Anton Parinov, Charles Fieseler, Manuel Zimmer
Behavior arises from the interplay between spontaneous brain dynamics and sensory-driven responses, yet how spontaneous neural activity shapes variability in decision-making remains unclear. We leverage the tractable C. elegans nervous system to address this question. During oxygen avoidance, we observe binary…
Pétur Kristófersson, Sigrún Þóra Sveinsdóttir, Sóley María Kristínardóttir, Stefnir Húni Kristjánsson + 1 more
Cardiovascular markers such as heart rate (HR), heart rate variability (HRV), and blood pressure (BP) are promising for low-intrusive monitoring of mental states relevant to safety-critical performance, yet evidence is mixed regarding which measures are most sensitive to cognitive workload, stress, and fatigue across…
M. Wakabayashi, A. Katayama, T. Asai
Research on impression evaluation from whole-body movements has traditionally focused on the relationships between emotional perception or aesthetic evaluation and movement patterns characterized by local kinematic features and inter-limb coordination. However, because observers perceive the entire body simultaneously…
Lou Thomas, Gaia Scerif, Hodo Yusuf, Mackenzie Laird + 3 more
Diffusion decision models (DDMs) offer the potential to go beyond standard accuracy and response-time indices to better understand perceptual decision-making in autism. One unanswered question is whether autistic participants can flexibly adjust the speed and accuracy of their decision-making according to task demands.…
Mathias Claeys, Neil Fam, Xiaojiao Xiao, Tejas Vyas + 10 more
Background Patient selection for transcatheter mitral valve edge-to-edge repair (MTEER) remains challenging, particularly in individuals with complex mitral valve anatomy. Conventional risk scores incorporate limited clinical variables and do not adequately account for detailed echocardiographic features, resulting in…
Yumi Shikauchi, Ryuta Aoki, Takashi Itahashi, Masaaki Shimizu + 5 more
Intrinsic neural timescales (INTs) index the temporal decay of neural activity and form a hierarchy from fast sensorimotor to slow transmodal regions. Although altered INTs have been reported in autism spectrum disorder (ASD), it remains unclear whether this hierarchical organization is preserved and how individual…
Aniol Santo-Angles, M Gyurkovics, K Jaworska, JM Palva + 2 more
Working memory representations of multiple items are maintained within quasi-orthogonal neural subspaces, a mechanism thought to reduce interference between memory contents. Previous studies in both non-human and human primates have demonstrated the existence of such subspaces, but it remains unclear how cognitive…