17 papers · ranked by Valyu relevance
Getnet Molla, Molalegne Bitew, Kunhong Xiao, Leanne Labriola
The field of personalized medicine is undergoing a transformative shift through the integration of multi-omics data, which mainly encompasses genomics, transcriptomics, proteomics, and metabolomics. This synergy allows for a comprehensive understanding of individual health by analyzing genetic, molecular, and…
Malak Qattan, Constantinos Demonacos, Marija Krstic-Demonacos
Standard clinical protocols and the concept “one drug fits all” that are currently used to treat illness in many cases are not effective, and strikingly so in the treatment of cancer, where 75% of therapeutic schemes are ineffective. The concept of personalized medicine is that the treatment of the disease is designed…
Sunita R. Nair
Personalized medicine has the potential of revolutionizing patient care. This treatment modality prescribes therapies specific to individual patients based on pharmacogenetic and pharmacogenomic information. The mapping of the human genome has been an important milestone in understanding the interindividual differences…
Lotfi Chouchane, Ravinder Mamtani, Ashraf Dallol, Javaid I Sheikh
An editorial about personalized medicine should perhaps start with a definition. Although several versions of such definition exist, we pay homage here to the oldest definition reported in modern medical literature. Sir William Osler (1849-1919) recognized that "variability is the law of life, and as no two faces are…
Ursula Gundert-Remy, Aleksandar Dimovski, Srećko Gajović
Reviewing the past and the present status of personalized medicine, the hope and promise from several years ago was critically compared to what is really achieved to tailor the drug treatment according to the patient’s individuality. The basis for consideration is what we know about the variant of the disease the…
Julius Alexander Steffen, Jan Simon Steffen
Personalized medicine can be seen as a continuously developing approach to tailoring treatments according to the individual characteristics of a patient. In some way, medicine has always been personalized. During the last decade, however, scientific and technological progress have made truly personalized healthcare…
T. Rajkumar
Currently, an individual is treated for a particular disease, based on the data obtained from thousands of other patients. A physician presumes that the new patient would also respond to the drugs which he prescribes. However, not always, do these presumptions turn out to be correct. Additionally, there could be…
Urs A. Meyer
A new vision of personalized medicine or personalized healthcare has evolved as a consequence of remarkable recent advances in technologies that allow to look at individual variation across the entire human genome and to identify personal risk factors behind many diseases and responses to therapy. These advances have…
Hanumantha Rao Balaji Raghavendran, Govindasamy Kumaramanickavel, Takeshi Iwata
'Takeshi Iwata'] Personalized medicine is a cutting-edge subspecialty of medicine. The American Cancer Society states that “Precision medicine is a way for healthcare professionals to offer and plan specific care for their patients, based on the specific genes, proteins, and other substances in a person's body” (1).…
Samuel F. Nassar, Khadir Raddassi, Baljit Ubhi, Joseph Doktorski + 1 more
The diagnosis and treatment of diseases such as cancer is becoming more accurate and specialized with the advent of precision medicine techniques, research and treatments. Reaching down to the cellular and even sub-cellular level, diagnostic tests can pinpoint specific, individual information from each patient, and…
João Renato Rebello Pinho, Roberta Sitnik, Cristóvão Luis Pitangueira Mangueira
'Cristóvão Luis Pitangueira Mangueira'] Personalized medicine is the use of biomarkers, most of them molecular markers, for detection of specific genetic traits to guide various approaches for preventing and treating different conditions. The identification of several genes related to heredity, oncology and infectious…
Manfred Maier
Nowadays, ‘personalized medicine’-often used interchangeably with ‘precision medicine’-is a trendy topic in popular and medical media. The term suggests a significant new development in clinical medicine; authors often claim a paradigm shift in healthcare. University hospitals proudly announce the founding or planning…
Adriano M Henney
The concept of personalized medicine is not new. It is being discussed with increasing interest in the medical, scientific, and general media because of the availability of advanced scientific and computational technologies, and the promise of the potential to improve the targeting and delivery of novel medicines. It…
Tim Maughan
Personalised medicine is widely considered as the way of the future for medicine. However, progress in cancer, with a few outstanding exceptions, has fallen below expectations because of the challenges of tumour heterogeneity and clonal evolution. In both benign and malignant disease, diseases caused by single genetic…
Roy C. Ziegelstein
Clinical practice guidelines have been developed for many common conditions based on data from randomized controlled trials. When medicine is informed solely by clinical practice guidelines, however, the patient is not treated as an individual, but rather as member of a group. Precision medicine, as defined herein…
Alexander Muacevic, John R Adler, Dharani S, Kamaraj R
Personalized medicine integrates genomics with clinical and familial histories, revolutionizing healthcare by tailoring treatments to individual patient characteristics. At its core, pharmacogenomics enables the customization of medication prescriptions based on genetic profiles, enhancing drug efficacy and safety.…
Daniel F Hayes, Hugh S Markus, R David Leslie, Eric J Topol
Personalized medicine is increasingly being employed across many areas of clinical practice, as genes associated with specific diseases are discovered and targeted therapies are developed. Mobile apps are also beginning to be used in medicine with the aim of providing a personalized approach to disease management. In…