6 papers · ranked by Valyu relevance
Jeffrey D. Walker, Paul Aparicio, Shreya Saxena, Nicholas G. Hatsopoulos + 1 more
The ability to record neural populations during natural behavior now allows us to ask whether canonical motor-cortical dynamics, defined largely in constrained reaches to static targets, also organize self-paced, feedback-rich actions that require continuous correction. We recorded sensorimotor cortex in marmosets…
Justin D Shin, Michael Satchell, Paul Miller, Shantanu P Jadhav + 2 more
REM (rapid eye movement) and non-REM (NREM) sleep stages contribute to systems memory consolidation in hippocampal-cortical circuits. However, the physiological mechanisms underlying REM memory processes remain relatively unclear compared to NREM memory reactivation. Here we report, in rodents, the existence of…
Prince Okyere, Junheng Li, Tobias Raufeisen, Ketevan Alania + 10 more
Memory consolidation during sleep depends on the precisely timed coordination of hippocampal reactivation with cortical slow oscillations and spindles. In humans this coupling has been characterised correlationally, while causal investigations have required intracranial stimulation in restricted patient cohorts or used…
Scott Rooney, Leanne Ahern, Edel Brennan, Eibhlis Cahalane + 8 more
For each interview/focus group transcript, two researchers (S.R., K.T., C.E., L.A., R.M.C.) independently read and inductively generated preliminary codes using NVivo 13 (QSR International). The coding pairs varied across transcripts, but one member of the research team (L.A.) coded all transcripts to ensure…
Phillip M. Gray, Phoebe Perham, Ben Andrews
Data were collected through focus groups, which were selected to maximize time efficiency and provide rich data through the snowballing of ideas. Sessions were conducted on one occasion between May and June 2023, either face-to-face or online via Teams or Zoom. Online focus groups offered participants logistical…
Alexander Muacevic, John R Adler, Jeet H Chaudhary, Jiya O Chacko + 3 more
Background and objective Duchenne muscular dystrophy (DMD) is a severe, progressive, X-linked genetic disorder caused by pathogenic variants in the dystrophin gene, leading to progressive muscle weakness, loss of ambulation, and premature mortality. Clinical trials are essential for advancing evidence-based management…