10 papers · ranked by Valyu relevance
Joshua Rule, Eric Schulz, Steven T. Piantadosi, Joshua B. Tenenbaum
Humans master complex systems of interrelated concepts like mathematics and natural language. Previous work suggests learning these systems relies on iteratively and directly revising a language-like conceptual representation. We introduce and assess a novel concept learning paradigm called Martha’s Magical Machines…
Ji Zha, Jasmine Alexander-Floyd, Tali Gidalevitz
Differentiation of secretory cells leads to sharp increases in protein synthesis, challenging ER proteostasis. Anticipatory activation of the unfolded protein response (UPR) prepares cells for the onset of secretory function by expanding the ER size and folding capacity. How cells ensure that the repertoire of induced…
Ator Ashoti, Anna Alemany, Fanny Sage, Niels Geijsen
Facioscapulohumeral muscular dystrophy (FSHD) is a muscle degenerative disease that disproportionally affects the muscles of the face, shoulder girdle and upper arms. FSHD is caused by the misexpression of Double Homeobox 4 (DUX4), a transcription factor that is normally expressed during early embryonic development.…
S Selma, N Sanmartín, A Espinosa-Ruiz, S Gianoglio + 5 more
Transcriptional regulators based on CRISPR architecture expand our ability of reprogramming endogenous gene expression in plants. One of their potential applications is the customization of plant metabolome through the activation of selected enzymes in a given metabolic pathway. Using the previously described…
Dana Goldberg, Nufar Buchshtab, Meital Charni-Natan, Ido Goldstein
During fasting, bodily homeostasis is maintained due to hepatic production of glucose (gluconeogenesis) and ketone bodies (ketogenesis). The main hormones governing hepatic fuel production are glucagon and glucocorticoids that initiate transcriptional programs aimed at supporting gluconeogenesis and ketogenesis. Using…
Ricardo Iván Martínez-Zamudio, Pierre-François Roux, José Américo N L F de Freitas, Lucas Robinson + 5 more
Senescent cells play important physiological- and pathophysiological roles in tumor suppression, tissue regeneration, and aging. While select genetic and epigenetic elements crucial for senescence induction were identified, the dynamics, underlying epigenetic mechanisms, and regulatory networks defining senescence…
George Chao, Evan Appleton, Clair S. Gutierrez, Lilia Evgeniou + 4 more
Pluripotent cells specialize into numerous cell types by receiving external signals, making fate decisions, and executing differentiation functions – a paradigm similar to computer algorithms. While advances in biosensor design have enabled cells to respond to diverse stimuli, the ability to maintain a synthetic memory…
Min Soo Kim, Hyun Sook Lee, Yun Jae Kim, Sung Gyun Kang + 2 more
The loss of imprinting of MEST has been linked to certain types of cancer by promoter switching. However, MEST-mediated regulation of tumorigenicity and metastasis are yet to be understood. Herein, we reported that MEST is a key regulator of IL-6/JAK/STAT3/Twist-1 signal pathway-mediated tumor metastasis. Enhanced MEST…
Andrew Schulz, Cassie Shriver, Anika Patka, Caroline Greiner + 5 more
The need for sustainability-minded engineers prepared to address complex societal challenges has grown exponentially in recent years. Frameworks like the United Nations (UN) Sustainable Development Goals (SDGs) have begun to drive structural changes in engineering education, including new ABET accreditation focused on…
Jean Paulo Aparecido da Silva, José Marcelo Soriano Viana, Kaio Olimpio das Graças Dias, Jéssica Coutinho Silva + 2 more
For popcorn, obtaining and identifying haploids are still challenging steps. We aimed to induce and screen haploids in popcorn using the Navajo phenotype, seedling vigor and ploidy level. We used the Krasnodar Haploid Inducer (KHI) in crosses with 20 popcorn source germplasms and five maize controls. The field trial…