8 papers · ranked by Valyu relevance
John J. Vastola, Tejas Ramdas, Samuel J. Gershman
Cells store information in part by attaching molecular marks to proteins and DNA. But because marks can be randomly removed (e.g., due to ambient phosphatase activity) and added (e.g., due to ambient kinase activity), information encoding may be poor, and in the worst case marks may only store information on the time…
Patrícia Verdugo Pascoal, Deborah Bambil, Luisa Mayumi Arake de Tacca, Rayane Nunes Lima + 3 more
The accelerated exploration and engineering of nucleotide sequences are directed towards quantum mechanics and their intrinsic entanglements, implementing the qubits states, including the development of algorithms. The production rate of biological sequencing data has increased to approximately 1 Gb/h, but the ability…
Koushik Ghosh, Parthasarthi Sahu, Shashikanta Barik, Hemachander Subramanian
Enzymatic error correction ensures the fidelity of DNA replication, preserving biological information flow across evolutionary timescales. Error correction, as has been envisaged until now, requires the presence of sophisticated enzymes that utilize energy and/or information to correct errors. Here, we propose a…
Jing-Kai Fang, Yue-Feng Lin, Jun-Han Huang, Yibo Chen + 9 more
Computational biology holds immense promise as a domain that can leverage quantum advantages due to its involvement in a wide range of challenging computational tasks. Researchers have recently explored the applications of quantum computing in genome assembly implementation. However, the issue of repetitive sequences…
Koushik Ghosh, Parthasarthi Sahu, Shashikanta Barik, Hemachander Subramanian
Accurate propagation of sequence information in nucleic acids is central to the evolutionary dynamics of self-replicating systems. Modern biological systems achieve high fidelity using enzymes that actively correct errors through energy-driven mechanisms. However, such complex machinery was absent under prebiotic…
Namasi G Sankar, Georgios Miliotis, Simon Caton
Genome assembly is important in infectious disease surveillance, antimicrobial resistance monitoring, and cancer genomics. The task of reconstructing full genomic sequences from fragmented reads, can be framed as a large scale combinatorial optimisation problem. Recent advances in quantum computing have introduced new…
Basel Mansour, Daniel Kei Takahashi, George Rafaelyan
Accurate prediction of Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) properties is a central challenge in early-stage drug discovery, where experimental determination remains costly and time-consuming. In this work, we propose a quantum-inspired preprocessing framework in which statistical…
Andreas L. Gimpel, Wendelin J. Stark, Reinhard Heckel, Robert N. Grass
Efficient error-correction codes are crucial for realizing DNA’s potential as a long-lasting, high-density storage medium for digital data. At the same time, new workflows promising low-cost, resilient DNA data storage are challenging their design and error-correcting capabilities. This study characterizes the errors…