8 papers · ranked by Valyu relevance
Hamish G. Brown, Dan Smith, Benjamin C. Wardle, Eric Hanssen
In transmission electron microscopy (TEM) cameras are square or rectangular but beams are round. With a beam size chosen to fill the camera at a given image magnification, the circular lobes of the beam will extend beyond the camera’s field of view and irradiate areas that are not acquired on the camera, damaging and…
James Eckhardt, Zenan Xing, Vish Subramanian, Aditya Vaidya + 1 more
Seed germination research has evolved over the years, increasingly incorporating technology. Recent advances in phenotyping platforms have increased the accessibility of high throughput phenotyping technologies to more labs, leading to valuable insights into germination biology. These platforms benefit researchers by…
Shalaka Chitale, Wenxuan Wu, Avik Mukherjee, Herbert Lannon + 16 more
Recent advancements in high-throughput screening have focused on using multi-parametric readouts to characterize drug compound effects. While high-content imaging is commonly used, it only captures endpoint images of fixed cells. Here, we report a semiconductor 96-microplate platform which performs real-time…
María Andreína Francisco Rodríguez, Jordi Carreras Puigvert, Ola Spjuth
Microplates are indispensable in large-scale biomedical experiments but the physical location of samples and controls on the microplate can significantly affect the resulting data and quality metric values. We introduce a new method based on constraint programming for designing microplate layouts that reduces unwanted…
Rafael Gómez-Sjöberg, Joana P. Cabrera, Andrew T. Cote
A very large number of biology and biochemistry laboratory protocols require transferring liquid aliquots from individual containers into individual wells of a multi-well plate, from plates to individual containers, or from one plate to another. Doing this by hand without errors, such as skipping wells, placing two…
Mohammad Jouybar, Sophie van der Kallen, Sheen Sahebali, Carlijn Bouten + 1 more
This study investigates the impact of channel geometry and applied flow on the morphology and function of endothelial cells (ECs) within vessel-on-chip (VoC) models. Traditional organ-on-chip models often utilize rectangular cross-section channels, resulting in flat walls, sharp corners, and non-uniform wall shear…
William Benman, Pavan Iyengar, Thomas Mumford, Lukasz J. Bugaj
Temperature is a critical parameter for biological function, yet there is a lack of approaches to modulate the temperature of biological specimens in a dynamic and high-throughput manner. We present the thermoPlate, a device for programmable control of temperature in each well of a 96-well plate in a manner compatible…
Bernarda Huilén Medina, Pablo Andrés, Lara Negrin, Luisa V. Biolatti + 2 more
In vitro experimental radiobiology is a fundamental tool for understanding the cellular and molecular mechanisms involved in the response to ionizing radiation. Conventional experimental designs require separate irradiations to achieve different absorbed doses, thereby introducing experimental variability between…