Search · four archives
Search · four archives
3 papers · ranked by Valyu relevance
Matthew Disney, Amirhossein Taghavi, Jared Baisden, Jessica Childs-Disney + 1 more
RNA G4C2 and C4G2 repeat expansions in the chromosome 9 open reading frame 72 gene (C9orf72) are the most common cause of genetically defined amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), referred to as c9ALS/FTD. The gene is bidirectionally transcribed, producing G4C2 repeats, r(G4C2)exp, in…
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RNA–RNA interactions drive the formation of biomolecular condensates via liquid–liquid phase separation (LLPS), but the molecular mechanisms governing this phenomenon remain poorly understood. Here, we employ Martini 3 coarse-grained simulations to investigate phase transitions of G4C2 RNA repeats—sequences implicated…
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The WRN helicase has recently emerged as a promising therapeutic target for microsatellite instability (MSI)-high cancers. Here, we report LXW-P1, a potent WRN degrader derived from marine bromotyrosine alkaloids. Its molecular target was identified using an AI-guided, pathway-informed perturbation transcriptomics…