9 papers · ranked by Valyu relevance
Boyi Li, Luyao Liu, Kaikai Jin, Zanheng Huang + 8 more
In 2024, Monkeypox virus (MPXV) clade I has triggered outbreaks in several countries world-wide. MPXV clade I demonstrates enhanced virulence and transmissibility, with a case fatality rate reaching 10%. In response, we have developed a one-pot detection assay specifically targeting MPXV clade I, combining recombinase…
Leandro Lofeu, Ehsan Pashay Ahi
High-throughput sequencing has transformed biomonitoring by enabling scalable molecular inventories, but most programs still emphasize taxa lists. In this Perspective, Biomonitoring 3.0 is proposed as a framework that builds on molecular inventories to monitor ecological dynamics, interactions, and biological responses…
Jalaja Madhusudhanan, Anton Parinov, Charles Fieseler, Manuel Zimmer
Behavior arises from the interplay between spontaneous brain dynamics and sensory-driven responses, yet how spontaneous neural activity shapes variability in decision-making remains unclear. We leverage the tractable C. elegans nervous system to address this question. During oxygen avoidance, we observe binary…
Xinyi Cao, Chao Ye, Shengjie Ling, Ming Li + 3 more
Fiber-shaped electronic systems provide a promising platform for wearable sensing and intelligent textiles, yet the continuous processing of uncured silicone-based conductive materials remains challenging because of their low structural stability during fiber formation. Here, we develop a coaxial wet-spinning strategy…
Anda de Witte, Anouck Matthijs, Benjamin Parrell, Dante Mantini + 4 more
Aging is frequently perceived negatively due to its association with declines in brain and motor function yet not all aspects of brain function are equally affected. The cerebellum, a brain region closely linked to motor control, undergoes clear structural changes with age, but the impact of this degeneration on…
Minh Toan Chau, Bismark Bright Ofori-Manteaw, Jacob Leonard Ago, Kelly Bentley-Spuur + 2 more
Oncology sits at the centre of modern medicine and international healthcare systems. In 2022 alone, the world saw close to 20 million new cancer cases and 9.7 million cancer deaths [1]. Clinicians, guideline panels, and patients make high-stakes decisions in a rapidly evolving evidence ecosystem. Increasing use of…
Filippo Groppi, Jessica Ferrari
Spontaneous population bursts repeatedly expose synapses to correlated spike activity, but it is unclear whether such events reinforce pre-existing synaptic weight differences when precise firing order carries little information. We asked this in a conductance-based model of a bursting neuronal culture: 48 excitatory…
Nancy Hom, Connor Weidle, Marie Pancera, Kelly K. Lee
The circumsporozoite protein (CSP) on the surface of the sporozoite stage of Plasmodium falciparum parasites is one of the major malaria antigens recognized by the adaptive immune system. Antibodies against CSP can provide protection from malaria infection following mosquito bite of the human host. Recent studies have…
Coen S. Zandvoort, Charlotte C. Wissing, Jonathan Winter, Anna Kowalczyk + 4 more
Flexible motor control requires that movements adapt to changing temporal contexts. Here, we test whether flexible timing is driven by context-dependent encoding across cortico-cerebellar circuits and how neural dynamics within these circuits enable accurate performance. To overcome the signal-to-noise limitations of…