8 papers · ranked by Valyu relevance
Jalaja Madhusudhanan, Anton Parinov, Charles Fieseler, Manuel Zimmer
Behavior arises from the interplay between spontaneous brain dynamics and sensory-driven responses, yet how spontaneous neural activity shapes variability in decision-making remains unclear. We leverage the tractable C. elegans nervous system to address this question. During oxygen avoidance, we observe binary…
Jörn A. Quent, Kaixiang Zhuang, Xinyu Liang, Debin Zeng + 5 more
Detecting novelty is fundamental to adaptive memory, yet the neural comparisons that allow new events to be distinguished from prior experience are not fully understood. Hippocampal novelty signals are often framed as associative comparator responses that register violations of learned relationships. However…
Abdullah İyigün, Göker Yurdakul, Alper Dünki, Mehmet Ali Yayla
3.3### Response Distribution and Ceiling Effect The response distributions of all three models were markedly right-skewed, with 81.3%, 87.3%, and 95.8% of responses at the top two categories for Claude Sonnet 4.6, Gemini 3 Pro and GPT-5.2 respectively. The effect was most pronounced in the complications theme, where…
Eli J. Costa, Carolina Rios-Martinez, Cecelia J. Andrews, James E. Ferrell + 1 more
Quantitatively relating transcription factor (TF) input to gene expression output is central to understanding mammalian gene regulation and essential for designing predictable synthetic expression systems. However, even minimal synthetic systems often exhibit unexplained behaviors. In a widely used inducible mammalian…
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric + 7 more
Neoadjuvant chemoradiotherapy followed by total mesorectal excision is standard for locally advanced rectal cancer, but response varies and current markers are insufficient. This study integrates public bulk RNA-seq data to identify predictive features of response. TRIM54 and PABPC4 were upregulated in the responder…
Sarah A. Kemp, Sauro Salomoni, Pierre‐Louis Bazin, Luke Pash + 2 more
Action cancellation involves the termination of planned or ongoing movement, likely initiated in the cortex by the pre-supplementary motor area (preSMA) and inferior frontal gyrus (IFG). It is frequently examined using the stop-signal task; electromyography (EMG) studies have shown action cancellation (in stop trials)…
Coen S. Zandvoort, Charlotte C. Wissing, Jonathan Winter, Anna Kowalczyk + 4 more
Flexible motor control requires that movements adapt to changing temporal contexts. Here, we test whether flexible timing is driven by context-dependent encoding across cortico-cerebellar circuits and how neural dynamics within these circuits enable accurate performance. To overcome the signal-to-noise limitations of…
Lou Thomas, Gaia Scerif, Hodo Yusuf, Mackenzie Laird + 3 more
Diffusion decision models (DDMs) offer the potential to go beyond standard accuracy and response-time indices to better understand perceptual decision-making in autism. One unanswered question is whether autistic participants can flexibly adjust the speed and accuracy of their decision-making according to task demands.…