7 papers · ranked by Valyu relevance
Neha Kaul, Lucy Vivash, Susanna Chen, Lillian King + 15 more
The results of the study will be presented at national and international scientific meetings and published in peer-reviewed journals. In collaboration with the consumer advisory committee, the results will be publicized to the wider community. 2.5### Randomization and blinding Participants will be randomized 1:1 using…
Yiming Xue, Xiaojian Liu, Weimin Zhu, Shengfan Wang + 2 more
While protein-RNA interactions are fundamental to post-transcriptional processes, achieving a holistic understanding of their regulatory logic remains challenging. Current computational models often treat binding affinity, interface mapping, and RNA design as isolated tasks, thereby failing to provide a unified…
Amélie Barozet, Vincent Cabeli, Jean Ogier du Terrail, Alexey Rukhovich + 6 more
The development of climate-resilient crops would be greatly accelerated by models able to reason directly over plant genomic sequences and to pinpoint trait-associated regions or loci. Anticipating the impact of DNA base changes (variants) remains challenging, and understanding regulatory mechanisms is still an active…
Md. Zahid Hasan, Kazi Md Azman Hossain, Mohammad Anwar Hossain, Md Obaidul Haque + 3 more
2.1### Study Design This study is a multicenter, assessor-blinded, RCT comparing the effects of KT with NCE (experimental group) versus sham KT with NCE (control group) in a 1:1 ratio among 80 KOA patients in Bangladesh. Each group's intervention lasts 8 weeks, with three sessions per week, followed by a 6-month…
Odin Zhang, Jiaqi Wang, Tuscan Rock Thompson, Ziyi You + 3 more
Biomolecular interactions, including protein–protein interactions, protein–nucleic acid recognition, and protein–small molecule binding, underlie a wide range of biological processes and therapeutic mechanisms. Although recent de novo design methods can generate candidate binders for diverse molecular targets…
Alp Tartici, Mihajlo Stojkovic, Anru Tian, Michael C. Jewett + 2 more
Protein engineering has important implications in the bioeconomy, enabling applications in materials, medicine, and energy. A key challenge is designing protein sequences that have a specific form and function. Protein inverse folding seeks to address this challenge by identifying amino acid sequences compatible with a…
Linsui Deng, Kejun He, Xianyang Zhang
Mendelian randomization (MR) has been widely used to infer causal relationships between exposures and outcomes in epidemiological studies. However, classical MR assumptions can be violated when genetic variants are associated with outcomes through pathways other than the exposure, leading to uncorrelated and/or…