8 papers · ranked by Valyu relevance
Yiming Xue, Xiaojian Liu, Weimin Zhu, Shengfan Wang + 2 more
While protein-RNA interactions are fundamental to post-transcriptional processes, achieving a holistic understanding of their regulatory logic remains challenging. Current computational models often treat binding affinity, interface mapping, and RNA design as isolated tasks, thereby failing to provide a unified…
Kunyu Wang, Jon Paul Janet, Alessandro Tibo
Three-dimensional molecular generative models have emerged that produce de novo molecules both unconditionally and conditionally, e.g., within protein pockets. However, steering those models in a specific region of the chemical space that satisfies a set of desired properties remains challenging. In this study, we…
Lianne Gahan, Adélaïde Raguin, Partho Sakha De
Lignin’s complex and highly branched architecture plays a critical role in biomass utilisation. Yet, unravelling the intricate relation between lignin’s measurable structural features and the underlying biosynthesis dynamics remains a major challenge. This difficulty stems from the variability in monolignol and bond…
Hadeer Kamal, Amira Y. Haikal, Mahmoud M. Saafan
Traffic collisions and congestion represent significant challenges within intelligent transportation systems (ITS). Consequently, a vehicular ad-hoc network (VANET) has been established. Numerous architectures have been incorporated into VANETs to manage the extensive data generated by vehicles. Collaboration with fog…
Justin D Shin, Michael Satchell, Paul Miller, Shantanu P Jadhav + 2 more
REM (rapid eye movement) and non-REM (NREM) sleep stages contribute to systems memory consolidation in hippocampal-cortical circuits. However, the physiological mechanisms underlying REM memory processes remain relatively unclear compared to NREM memory reactivation. Here we report, in rodents, the existence of…
Sahar Alkhaibari, Feng Dong
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by persistent difficulties in social communication, social interaction, and repetitive behaviors. Early and accurate diagnosis is essential but is often hindered by subjective clinical assessments, limited data availability, and…
Hongling Gan, Guichun Huang, Lin Zhang, Lanyan Cen + 4 more
This study examined how the inoculation sequence of Saccharomyces cerevisiae (Sc) and Wickerhamomyces anomalus (Wa), along with Dendrobium nobile Lindl. (D. nobile) addition, affects rice wine quality. Sequential inoculation with D. nobile yielded the highest levels of polysaccharides, alkaloids, flavonoids, and…
Manuel Treutlein, Pascal Bothe, Marc Schmidt, Roman Hahn + 4 more
The last mile of the distribution grid is crucial for a successful energy transition, as more low-carbon technology like photovoltaic systems, heat pumps, and electric vehicle chargers connect to the low-voltage grid. Despite considerable challenges in operation and planning, researchers often lack access to suitable…