Search · four archives
Search · four archives
14 papers · ranked by Valyu relevance
Shweta Sahni, Partha Chattopadhyay, Kriti Khare, Rajesh Pandey + 1 more
'Inmaculada Martín-Burriel'] Since the time when detection of gene expression in single cells by microarrays to the Next Generation Sequencing (NGS) enabled Single Cell Genomics (SCG), it has played a pivotal role to understand and elucidate the functional role of cellular heterogeneity. Along this journey to becoming…
Maria A. Dimitriu, Irina Lazar-Contes, Martin Roszkowski, Isabelle M. Mansuy
'Isabelle M. Mansuy'] Recent advances in methods for single-cell analyses and barcoding strategies have led to considerable progress in research. The development of multiplexed assays offers the possibility to conduct parallel analyses of multiple factors and processes for comprehensive characterization of cellular and…
Getnet Molla Desta, Alemayehu Godana Birhanu
In recent years, significant advancements in biochemistry, materials science, engineering, and computer-aided testing have driven the development of high-throughput tools for profiling genetic information. Single-cell RNA sequencing (scRNA-seq) technologies have established themselves as key tools for dissecting…
Yanhua Tian, Qingqing Li, Zhenlin Yang, Shu Zhang + 17 more
'Zhijie Wang' 'Hua Bai' 'Jianchun Duan' 'Bo Zheng' 'Wen Li' 'Yueli Cui' 'Xin Wang' 'Rui Wan' 'Kailun Fei' 'Jia Zhong' 'Shugeng Gao' 'Jie He' 'Carl M. Gay' 'Jianjun Zhang' 'Jie Wang' 'Fuchou Tang'] Small-cell lung cancer (SCLC) is the most aggressive and lethal subtype of lung cancer, for which, better understandings of…
Haiyang Xie, Xianting Ding
Profiling protein expression at single-cell resolution is essential for fundamental biological research (such as cell differentiation and tumor microenvironmental examination) and clinical precision medicine where only a limited number of primary cells are permitted. With the recent advances in engineering, chemistry…
Qiang Shi, Xueyan Chen, Zemin Zhang
Over the past decade, advances in single-cell omics (SCO) technologies have enabled the investigation of cellular heterogeneity at an unprecedented resolution and scale, opening a new avenue for understanding human biology and disease. In this review, we summarize the developments of sequencing-based SCO technologies…
Siyuan Chen, Weibo Jiang, Yanhui Du, Manshi Yang + 3 more
'Huan Li' 'Mengying Cui'] Single-cell sequencing (SCS) technology is changing our understanding of cellular components, functions, and interactions across organisms, because of its inherent advantage of avoiding noise resulting from genotypic and phenotypic heterogeneity across numerous samples. By directly and…
Philippe Jean, Fabienne Wong Jun Tai, Amrit Singh-Estivalet, Andrea Lelli + 14 more
'Andrea Lelli' 'Cyril Scandola' 'Sébastien Megharba' 'Sandrine Schmutz' 'Solène Roux' 'Sabrina Mechaussier' 'Muriel Sudres' 'Enguerran Mouly' 'Anne-Valérie Heritier' 'Crystel Bonnet' 'Adeline Mallet' 'Sophie Novault' 'Valentina Libri' 'Christine Petit' 'Nicolas Michalski'] Title: Significance An increasing number of…
Mohammad Saidur Rhaman, Muhammad Ali, Wenxiu Ye, Bosheng Li + 1 more
Plants possess diverse cell types and intricate regulatory mechanisms to adapt to the ever-changing environment of nature. Various strategies have been employed to study cell types and their developmental progressions, including single-cell sequencing methods which provide high-dimensional catalogs to address…
Hongfei Li, Jiechen Wang, Qing Liu, Quan Zou + 1 more
Joint profiling technologies combining single-cell chromatin accessibility (CA) and transcriptome sequencing enable cellular heterogeneity analysis from both gene and cis-regulatory element perspectives, greatly advancing molecular biology at a cellular resolution. These techniques have been used to construct gene…
Haoxuan Luo, Ansar Hussain, Musavir Abbas, Lun Yuan + 5 more
Droplet-based single-cell RNA sequencing (scRNA-seq) has redefined biological research by resolving cellular heterogeneity with an unprecedented precision. This review synthesizes the technological evolution of the 10× Genomics Chromium platform, its Gel Bead-in-Emulsion (GEM)s technology, and end-to-end workflows…
Kayleigh Casmey, Maria Zimmermann, Yuxin Xie, Sierra A. Codeluppi-Arrowsmith + 2 more
Single-cell omics technology has advanced rapidly since its inception, offering increasing precision, resolution, and technical diversity to explore cell-specific molecular features in the human brain and neuropsychiatric disorders. While traditional bulk genomic analyses have provided valuable insights into the…
Su-Hyeon Lee, Junha Park, Byungjin Hwang
Single-cell technologies have undergone a significant transformation, expanding from their initial focus on transcriptomics to encompass a diverse range of modalities. Recent advancements have markedly improved scalability and reduced costs, facilitating the processing of larger cell populations and broadening the…
Haiyue Bi, Xiaocheng Weng
The meticulous examination of the genomic, transcriptomic, epigenomic, and proteomic landscapes, conducted at the precise resolution of single cells, has emerged as an indispensable instrument for comprehending the inherent mechanisms governing cellular heterogeneity. These methodologies have provided unprecedented…