16 papers · ranked by Valyu relevance
Lucas M. Stolerman, Michael Getz, Stefan G. Llewellyn Smith, Michael Holst + 1 more
Protein aggregation on the plasma membrane (PM) is of critical importance to many cellular processes such as cell adhesion, endocytosis, fibrillar conformation, and vesicle transport. Lateral diffusion of protein aggregates or clusters on the surface of the PM plays an important role in governing their heterogeneous…
Noah Olsman, Ania-Ariadna Baetica, Fangzhou Xiao, Yoke Peng Leong + 2 more
A common feature of both biological and man-made systems is the use of feedback to control their behavior. In this paper, we explore a particular model of biomolecular feedback implemented using a sequestration mechanism. This has been demonstrated to implement robust perfect adaption, often referred to as integral…
Manjyot Singh Bedi, Krzysztof Argasinski, Mark Broom
In this paper we extend a modeling framework that embeds ecological realism by examining how demographic factors determine payoffs, which are subsequently incorporated into evolutionary game models. In particular, it segregates births and deaths, as well as activities in addition to the between player interactions…
Hendrik Reimann, Sjoerd M. Bruijn
The walking human body is mechanically unstable. Loss of stability and falling is more likely in certain groups of people, such as older adults or people with neuromotor impairments, as well as in certain situations, such as when experiencing conflicting or distracting sensory inputs. Stability during walking is often…
Dasuni Amanda Salpadoru, Matthew P. Adams, Kate Helmstedt, David J. Warne
Ecological regime shifts are potentially a common property of ecosystems, describing transitions between alternative stable states that can represent healthy or unhealthy conditions under the same environmental drivers. Once a tipping point, defined as a critical threshold separating alternative stable states, is…
Jian Jin, Dinant Kistemaker, Jaap H. van Dieën, Andreas Daffertshofer + 1 more
Identification of individuals at risk of falling is important when designing fall prevention methods. Current measures that estimate gait stability and robustness appear limited in predicting falls in older adults. Inspired by recent findings on changes in phase-dependent local stability within a gait cycle, we devised…
Lakshdeep Gill, Andrew H. Huntley, Avril Mansfield
This study aimed to determine the validity of the centre of mass position (COM) position and extrapolated COM (XCOM), relative to the base of support, for predicting stability during a walking task where the base of support is constrained. Nine young healthy participants walked on a narrow beam. Three-dimensional…
Marcelo Bussotti Reyes, Ramon Huerta, Pedro Valadão Carelli, Reynaldo D. Pinto + 2 more
The stability of rhythmic activity in neural networks is an important aspect in the study of central pattern generators (CPGs). Different from other physiological rhythms, the activity of CPGs has not been fully characterized in terms of its stability, especially using quantitative methods. We propose a method that…
Jasmine A. Nirody, Padmini Rangamani
Mathematical modeling is now used commonly in the analysis of signaling networks. With advances in high resolution microscopy, the spatial location of different signaling molecules and the spatio-temporal dynamics of signaling microdomains are now widely acknowledged as key features of biochemical signal transduction.…
Marcelo Bussotti Reyes, Ramon Huerta, Pedro Valadão Carelli, Reynaldo D. Pinto + 2 more
The stability of rhythmic activity in neural networks is an important aspect in the study of central pattern generators (CPGs). Different from other physiological rhythms, the activity of CPGs has not been fully characterized in terms of its stability, especially using quantitative methods. We propose a method that…
Gianmarco Ducci, Gennaro Vitucci, Philippe Chatelain, Renaud Ronsse
Migratory birds travel over impressively long distances. Consequently, they have to adopt flight regimes being both efficient - in order to spare their metabolic resources - and robust to perturbations. This paper investigates the relationship between both aspects, i.e. mechanical performance and stability in flapping…
Francesca Arese Lucini, Flaviano Morone, Maria S. Tomassone, Hernán A. Makse
In 1972, Robert May showed that diversity is detrimental to an ecosystem since, as the number of species increases, the ecosystem is less stable. This is the so-called diversity-stability paradox, which has been derived by considering a mathematical model with linear interactions between the species. Despite being in…
Jian Jin, Dinant Kistemaker, Jaap H. van Dieën, Andreas Daffertshofer + 1 more
Predicting gait robustness is useful for targeting interventions to prevent falls. A first step towards this is to properly quantify gait robustness. However, this step already comes with challenges, as humans can withstand different magnitudes of perturbations at different phases in a gait cycle. Earlier, we showed…
Chuyi Cui, Ashwini Kulkarni, Shirley Rietdyk, Satyajit Ambike
During community ambulation, anticipatory adaptations in gait are key for navigating built, populated and natural environments. It has been argued that some instability in gait can be functionally beneficial in situations demanding high maneuverability, and while the mechanisms utilized to maintain locomotor balance…
Rina M. Magnani, Jaap H. van Dieën, Sjoerd M. Bruijn
Vestibular information modulates muscle activity during gait, presumably to contribute to stability. If this is the case, stronger effects of perturbing vestibular stimulation on gait stability can be expected for narrow-base walking (which needs more control) than for normal walking and smaller effects for wide-base…
Shoujun Yu, Wenji Yue, Tianruo Guo, Yonghong Liu + 10 more
Repetitive electrical nerve stimulation can induce a long-lasting perturbation of the axon’s membrane potential, resulting in unstable stimulus-response relationships. Despite being observed in electrophysiology, the precise mechanisms underlying stimulus-induced instability is still an open question due to the lack of…