11 papers · ranked by Valyu relevance
Susmida Seni Balakrishnan, Sivaraman Manjini, S Dhina, Kshirabdhi Dhal + 2 more
The Dengue virus (DENV), a major global health concern, causes dengue fever, predominantly affecting tropical and subtropical regions. The NS2B-NS3 protease complex of DENV is critical for viral replication, making it a promising target for antiviral drug development. This study investigates the structural dynamics of…
Manasi Bora, Prokriti Paul, Sanchaita Rajkhowa, Harshita Sonar + 4 more
The rapid rise of multidrug-resistant (MDR) Klebsiella pneumoniae has created a major global health challenge due to the limited availability of conserved therapeutic targets effective across diverse resistant strains. In this study, an integrative computational target-discovery and drug-repurposing framework was…
Eliezer Masliah
How transient neural representations become integrated and stable enough to function as internal neural models remains incompletely understood. Grounded in efficient coding, Bayesian and predictive frameworks, recurrent and attractor dynamics, neural state-space models, and systems neuroscience, the Principle of…
Panhong Yu, Yang Xue, Chao Li, Sunan Wang + 4 more
Water-in-oil (W/O) emulsions are widely encountered in petroleum production, separation processes, and functional emulsion formulations. In practical systems, the dispersed aqueous phase commonly contains dissolved salts, whereas their influence on W/O emulsion stability is still not fully understood. This review…
Samira Malekiazar, Alireza Rahman, Mohammadreza Khani, Toktam Mostaghim + 1 more
Meat and its derivatives are susceptible to lipid and protein oxidation during processing and storage, negatively affecting product quality and stability. Oxidative processes can reduce nutritional value, flavor, texture, and shelf life. In this study, the effects of essential oils of two aromatic herbs [Echinophora…
Polina Bombina, Kevin R. Coombes
Comparative studies of trajectory inference (TI) methods evaluate complete computational pipelines, making it impossible to isolate how much distortion is introduced specifically by the dimensionality reduction (DR) step. To our knowledge, no study has directly and systematically evaluated how well DR methods alone…
Cornelia Wrzus, Gabriela Küchler, Kira S. A. Borgdorf, Corina Aguilar-Raab
Past research on how people evaluate and compare themselves in central characteristics focuses strongly on preconditions, processes, and consequences of such comparisons while neglecting individual differences. The current study bridges social and personality research by examining domain specificity, temporal…
Taha M. Tiama, Islam G. Ali, Ahmed E. Samer, Mariam F. Gabriel + 2 more
The interfacial electronic structure of biopolymer-metal oxide hybrids determine their stability, yet this structure is still not well understood. Here, we report a density functional theory study of 10 model systems consisting of cellulose and chitosan functionalized with ZnO and V2O5 separately and in ternary…
John Tower
Biological information is generally thought to be subject to selection for faithful maintenance. However, accurate preservation is often combined with regulated mechanisms that generate state change. Selectively advantageous instability (SAI) is modeled here as instability that is favored because useful alternatives…
Gi-Young Jang, Hyobeom Lee, Kang-Il Kim
Background Single-radius total knee arthroplasty (TKA) has demonstrated favorable clinical outcomes and survivorship; however, long-term comparative data between cruciate-retaining (CR) and posterior-stabilized (PS) designs within a single-radius system remain limited, particularly in Asian populations. This study…
Wouter Muijres, Maarten Afschrift, Renaud Ronsse, Tom Van Wouwe + 1 more
The high metabolic cost of walking in individuals with a transtibial amputation is often attributed to reduced ankle propulsion. However, the cost of stabilizing walking may also increase after amputation, potentially explaining why restoring ankle propulsion does not always normalize metabolic cost. Because the…