PPubMed6 Sep 2026
A Systematic Review and Meta‐Analysis of Malnutrition and Metabolic Failure in High‐Potency Incretin Therapy
Eugene Ampofo, Charles Apprey, Mary Amoako, Fiifi Derrick Turkson
3.1### Clinical Magnitude of Treatment-Induced Energy Restriction Once-daily oral semaglutide 50 mg produced a 39.20% relative reduction in energy intake by week 20. This profound restriction meant a treatment difference of −1009 kJ (∼241 kcal) during a single ad libitum lunch compared to placebo. Across the 19…