11 papers · ranked by Valyu relevance
Andrea K Barreiro, Antonio J Fontenele, Cheng Ly, Prashant Raju + 2 more
As information about the world is conveyed from the sensory periphery to central neural circuits, it mixes with complex ongoing cortical activity. How do neural populations keep track of sensory signals, separating them from noisy ongoing activity? Here we show that sensory signals are encoded more reliably in certain…
Justin M. Fine, Seng Bum Michael Yoo, R. Becket Ebitz, Benjamin Y. Hayden
To choose between options, we must solve two important binding problems. First, the features that determine each options’ values must be appropriately combined and kept separate from the corresponding features of other options. Second, options must be associated with the specific actions needed to select them. We…
Pablo T. Wentz, Scott L. Brincat, Anitha Pasupathy, Earl K. Miller
Cortical spiking activity in areas like prefrontal cortex (PFC) encodes information only along a small number of dimensions, a subspace of the full space of population activity patterns. PFC often uses distinct subspaces to represent incoming sensory information and to maintain it in working memory. However, it’s…
Hsin-Hung Li, Clayton E. Curtis
Working memory (WM) depends on the activity of neural populations to maintain internal representations of information that are no longer available in the environment. The neural population dynamics that support WM in the human cortex remain largely unexplored. Utilizing fMRI and time-resolved multivariate analyses, we…
Laura López-Galdo, Simon Nougaret, Demian Battaglia, Bjørg Elisabeth Kilavik
Functional multiplexing is a signature of higher-order brain regions. Beyond single-unit mixed selectivity, the six-layered cortical microcircuit has been proposed as an optimal substrate for such parallel computations. Recurrent connections within and across layers allow cortical columns to retain incoming information…
Yaara Erez, Mikiko Kadohisa, Philippe Petrov, Natasha Sigala + 3 more
Complex neural dynamics in the prefrontal cortex contribute to context-dependent decisions and attentional competition. To analyze these dynamics, we apply demixed principal component analysis to activity of a primate prefrontal cell sample recorded in a cued target detection task. The results track dynamics of cue and…
William Dorrell, Peter E. Latham, Timothy E. J. Behrens, James C. R. Whittington
The efficient coding hypothesis presents a compelling success story for theoretical and systems neuroscience. It marshals a unifying idea, that neural codes can be understood as efficient encodings of natural stimuli, to explain phenomena from across sensory systems, sometimes with exquisite precision. However, similar…
Aishwarya Parthasarathy, Cheng Tang, Roger Herikstad, Loong Fah Cheong + 2 more
Endogenous processes allow the maintenance of working memories. These processes presumably involve prefrontal networks with strong recurrent connections. Distractors evoke a morphing of the population code, even when memories are stable. But it is unclear whether these dynamic population responses contain stable memory…
Kyle Bojanek, Olivier Marre, Stephanie E. Palmer
Populations of sensory neurons are thought to be shaped by selective pressures for optimal information transmission, yet real neural circuits display substantial variability across stimulus repeats, across time, and between individuals. Reconciling this variability with normative theories requires understanding not…
Lihong Cao
The human brain encodes a virtually infinite repertoire of semantic concepts using a finite number of neurons, a feat that defies the capacity limits of classical attractor networks. While “Concept Cells” in the medial temporal lobe (MTL) exhibit extreme sparsity, the information-theoretic principles governing their…
Shubham Chandak, Kedar Tatwawadi, Billy Lau, Jay Mardia + 6 more
With the amount of data being stored increasing rapidly, there is significant interest in exploring alternative storage technologies. In this context, DNA-based storage systems can offer significantly higher storage densities (petabytes/gram) and durability (thousands of years) than current technologies. Specifically…