10 papers · ranked by Valyu relevance
Felipe Coelho Argolo
Conant-Ashby’s (‘good regulator’) theorem states that a simple regulator of a system must behave as an image of it. Notably, evolutionary features present in living beings often mirror natural processes, yielding symmetries between biological structures and the external environment. For instance, nervous cells can…
Laura Muñoz-Baena, Hugo G. Castelán-Sánchez, Sareh Bagherichimeh, Paula Magbor + 4 more
RNA viruses evolve rapidly to adapt to changing host environments. Much of this adaptation occurs at the level of protein-coding genes. Thus, some of the most well-characterized examples of rapid adaptation have been found in virus proteins that are exposed on the surface of the viral particle, where they mediate host…
Amirhossein Khalilian-Gourtani, Yasamin Esmaeili, Andrew J. Michalak, Adeen Flinker
Intracranial electrophysiological recordings, including electrocorticography (ECoG) and stereo-EEG (sEEG), are increasingly used across research programs to study human brain function due to their high spatiotemporal resolution. Numerous tools exist for electrode localization and visualization; however, most focus on…
Fidha Nazreen Kunnath Muhammedkutty, Huan-Xiang Zhou
Membrane association of intrinsically disordered proteins (IDPs) mediates various cellular functions including membrane remodeling and signal transduction. Whereas membrane association through amphipathic helices and polybasic motifs is well understood, sequence determinants for deep membrane insertion of aromatic…
Abdul M. Bhuiya, Siddhansh Agarwal, Carlos F. Ng, Melanie Ott + 2 more
CRISPR-based assays offer sensitive and specific nucleic acid detection for a broad range of diagnostic and surveillance applications. While standard solution-based assays are simple, they typically lack the ability to detect multiple targets individually without the need for more complex instrumentation and multi-step…
Ethan Xiao, Shuguang Zhang
Human aquaporins (AQPs) are essential membrane channels, yet their inherent hydrophobicity complicates structural and functional studies. We present the systematic application of the QTY code to human AQPs, integrating it with AlphaFold 3 structure prediction to design and validate that four-representative human AQPs…
Yahui Wei, Haiyan Wang, Yufan Wang, Lixin Chen + 9 more
Macaque brain MRI is central to translational and comparative neuroscience, yet multi-site, longitudinal, and cross-species analyses are hindered by a lack of unified, automated structural processing tools. Existing pipelines, mostly adapted from human neuroimaging or restricted to fragmented steps, fail to provide…
Z. V. Parlak, N. Labude-Weber, A. Krause, K. Neuhaus + 10 more
Thrombogenicity causes significant complications in the application of blood-contacting implants, requiring strategies to prevent adverse coagulation reactions. The thrombotic responses to the foreign surfaces are mainly driven by surficial factors such as surface energy, topography, and electrochemical interactions.…
Jung-Hoon Kim, Yizhen Zhang, Owen MacKenzie, Xiaokai Wang + 3 more
The cerebral cortex constrains its spontaneous activity to a low-dimensional manifold learnable from resting state functional magnetic resonance imaging (fMRI) data. However, it remains unclear whether this intrinsic manifold also captures cortical responses to complex, naturalistic stimuli. To test this, we pretrained…
Erhard Bieberich
Consciousness remains poorly understood as a causative force: existing theories treat it as an epiphenomenal correlate of neural activity rather than explaining how inner experience controls its substrate. I present Recurrent Integration Fractal Theory (RIFT), proposing that consciousness arises when fractal…