15 papers · ranked by Valyu relevance
M. K. Bell, P. Rangamani
Synaptic plasticity involves the modification of both biochemical and structural components of neurons. Many studies have revealed that the change in the number density of the glutamatergic receptor AMPAR at the synapse is proportional to synaptic weight update; increase in AMPAR corresponds to strengthening of…
Paulo R. Protachevicz, Antonio M. Batista, Iberê L. Caldas, Murilo S. Baptista
Synaptic dynamics plays a key role in neuronal communication. Due to its high-dimensionality, the main fundamental mechanisms triggering different synaptic dynamics and its relation with the neurotransmitters release regimes (facilitation, biphasic, and depression) are still elusive. For a general set of parameters…
Andrew R. Gallimore, Iain Hepburn, Silvio Rizzoli, Erik De Schutter
Synaptic transmission is driven by a complex cycle of synaptic vesicle docking, release, and recycling, and maintained by distinct vesicle pools with differing propensities for docking and release. However, the partitioning of vesicles into distinct pools and the conditions under which they are recruited from the…
Petros Evgenios Vlachos, Jochen Triesch
Learned information and experiences are thought to be stored in synapses, composed of building block molecules whose number typically correlates with synaptic strength. Activity-dependent plasticity mechanisms, such as Hebbian learning, regulate these building blocks, promoting synaptic growth to encode acquired…
Jade Poirier, John Beninger, Katalin Tóth, Richard Naud
The language of the brain is articulated by temporal patterns of neuronal activity, which individual synapses interpret through distinct forms of synaptic dynamics. While glutamatergic synapses have been proposed to use a handful of functionally distinct types of short-term plasticity (STP) that loosely align with…
Fabian A. Mikulasch, Svilen V. Georgiev, Lucas Rudelt, Silvio O. Rizzoli + 1 more
After synaptic transmission, fused synaptic vesicles are recycled, enabling the synapse to recover its capacity for renewed release. The recovery steps, which range from endocytosis to vesicle docking and priming, have been studied individually, but it is not clear what their impact on the overall dynamics of synaptic…
Jana Kroll, Uljana Kravčenko, Mohsen Sadeghi, Christoph A. Diebolder + 6 more
During neurotransmission, presynaptic action potentials trigger synaptic vesicle fusion with the plasma membrane within milliseconds. To visualize membrane dynamics before, during, and right after vesicle fusion at central synapses under near-native conditions, we developed an experimental strategy for time-resolved in…
Francesco Negri, Jannik Luboeinski, Christian Tetzlaff, Michael Fauth
According to the synaptic tagging-and-capture hypothesis, long-term synaptic plasticity requires postsynaptic sites to establish a synaptic tag, enabling them to capture plasticity-related products synthesized elsewhere in the neuron. Although electrophysiological studies have provided evidence for the existence of…
Chelsy R. Eddings, Shigeki Watanabe
Neural circuitry depends on excitatory and inhibitory regulation of activity to yield functional outputs. However, examinations of synaptic vesicle recycling have focused heavily on excitatory synapses, leaving many questions unanswered for inhibitory synapse dynamics. Here we show that both excitatory and inhibitory…
Grit Bornschein, Simone Brachtendorf, Abdelmoneim Eshra, Robert Kraft + 3 more
Synaptotagmin 1 (Syt1) and Syt2 are the main Ca^2+^ sensors triggering synchronous release in the brain. The Ca^2+^-sensitivity of Syt2-triggered release has been studied in detail. However, for Syt1, the dominating isoform in the neocortex, quantitative detail is lacking. We measured the Ca^2+^-dependency of…
Felicitas Bruentgens, Laura Moreno Velasquez, Alexander Stumpf, Daniel Parthier + 5 more
Synapsins are highly abundant presynaptic proteins that play a crucial role in neurotransmission and plasticity via the clustering of synaptic vesicles. The synapsin III isoform is usually downregulated after development, but in hippocampal mossy fiber boutons it persists in adulthood. Mossy fiber boutons express…
Yoichi Araki, Kacey E. Rajkovich, Elizabeth E. Gerber, Timothy R. Gamache + 6 more
SynGAP is an abundant synaptic GTPase-activating protein (GAP) critical for synaptic plasticity, learning, memory, and cognition. Mutations in SYNGAP1 in humans result in intellectual disability, autistic-like behaviors, and epilepsy. Heterozygous Syngap1 knockout mice display deficits in synaptic plasticity, learning…
Estelle Toulmé, Andrea Salazar Lázaro, Thorsten Trimbuch, Josep Rizo + 1 more
The Ca^2+^ sensor synaptotagmin-1 triggers neurotransmitter release together with the neuronal SNARE complex formed by syntaxin-1, SNAP25 and synaptobrevin. Moreover, synaptotagmin-1 increases synaptic vesicle priming and impairs spontaneous vesicle release. The synaptotagmin-1 C_2_B domain binds to the SNARE complex…
Daniel Trpevski, Jeanette Hellgren Kotaleski, Matthias Hennig
Inhibitory synapses can control a neuron’s firing rate and also control supralinear dendritic integration. It is not known how inhibitory synapses can learn to perform these functions using only signals available locally at the synaptic site. We study an inhibitory plasticity rule based on the Bienenstock-Cooper-Munro…
A.A. Osipova, I.V. Smirnov, M.P. Smirnova, A.A. Borodinova + 2 more
Heterosynaptic plasticity, along with Hebbian homosynaptic plasticity, is an important mechanism ensuring stable operation of learning neuronal networks. However, whether heterosynaptic plasticity occurs in the whole brain in vivo, and what role(s) in brain function in vivo it could play, remains unclear. Here, we used…