17 papers · ranked by Valyu relevance
Vos, Gideon, van Eijk, Liza + 4 more
- We propose a magnitude-based synaptic pruning method as a regularization approach - The method emulates biological synaptic pruning by dynamically and progressively eliminating low-importance neural connections - Experiments across RNN, LSTM, and PatchTST models show statistically significant error reductions - Our…
Ukyo T. Tazawa, Takuya Isomura
Identifying appropriate structures for generative or world models is essential for both biological organisms and machines. This work shows that synaptic pruning facilitates efficient statistical structure learning. We extend previously established canonical neural networks to derive a synaptic pruning scheme that is…
Yakang Xing, Yi Mo, Qihui Chen, Xiao Li
Synaptic pruning is a crucial process in synaptic refinement, eliminating unstable synaptic connections in neural circuits. This process is triggered and regulated primarily by spontaneous neural activity and experience-dependent mechanisms. The pruning process involves multiple molecular signals and a series of…
Côme Camus, Léa Leval, Viviana Villicana-Munoz, Sarka Jelinkova + 5 more
Title: Summary Long-term depression (LTD) is an activity-dependent decrease in synaptic strength. This state initiates either a re-potentiation or a loss, aka pruning, of the synapse within hours to days following its induction. However, the precise relationship between LTD and synaptic pruning remains elusive. Using…
Hongying Liu, Min Jiang, Zhiying Chen, Chuan Li + 3 more
'Xiaorong Zhang' 'Moxin Wu'] Stroke is a serious disease that can lead to local neurological dysfunction and cause great harm to the patient’s health due to blood cerebral circulation disorder. Synaptic pruning is critical for the normal development of the human brain, which makes the synaptic circuit completer and…
Bing Han, Feifei Zhao, Yi Zeng, Guobin Shen
—Developmental plasticity plays a prominent role in shaping the brain's structure during ongoing learning in response to dynamically changing environments. However, the existing network compression methods for deep artificial neural networks (ANNs) and spiking neural networks (SNNs) draw little inspiration from brain's…
Zachary Watson, Shao-Jun Tang, Xuesong Chen
Even in the era of effective antiretroviral therapies, people living with Human Immunodeficiency Virus (HIV) are burdened with debilitating neurological dysfunction, such as HIV-associated neurocognitive disorders (HAND) and HIV-associated pain, for which there are no FDA approved treatments. Disruption to the neural…
Agnieszka Pawlak, Jakub Stefanowicz, Zofia Kotkowska, Agata Gabryelska + 4 more
1## Introduction Recent advances in neuroscience have reinforced the hypothesis that schizophrenia is a neurodevelopmental disorder, with its roots tracing back to early brain maturation processes (; ; ). One of the most consistently implicated mechanisms is excessive synaptic pruning during adolescence, a period…
Chen Yu, Xiao-Peng Zhang, Wei Wang
Autism spectrum disorder (ASD) has been increasingly associated with abnormalities in synaptic pruning. Although significant progress has been made in elucidating the genetic and immunological underpinnings of ASD, its core pathological mechanisms remain poorly understood. In this study, we developed a network model…
Huihong Li, Zhiran Xie, Yuxuan Tian, Yaxi Yang + 12 more
Alzheimer’s disease (AD) and epilepsy (EP) share a complex bidirectional relationship, yet the molecular mechanisms underlying their comorbidity remain insufficiently explored. To identify potential consensus transcriptional programs across animal models and human patients with AD and EP, we conducted comprehensive…
Sanjith Senthil, Rishidev Chaudhuri
The pruning of network connections is key to brain function but, despite its importance, there exist few biologically-plausible pruning rules with demonstrated good performance. In this work we evaluate noise-prune, a recently introduced unsupervised local pruning rule for recurrent networks that uses noisy…
Ngo Cheung
Background Obsessive-compulsive disorder (OCD) is characterized by intrusive thoughts and repetitive behaviors, with incomplete response to current treatments suggesting limitations in prevailing neurotransmitter-focused models. Epidemiological data indicate lifetime DSM-IV OCD in approximately 2.3% and 12-month OCD in…
Rodrigo S. Kazu, Kleber Neves, Bruno Mota
connectivity Authors: ['Rodrigo S. Kazu' 'Kleber Neves' 'Bruno Mota'] From the proliferative mechanisms generating neurons from progenitor cells to neuron migration and synaptic connection formation, several vicissitudes culminate in the mature brain. Both component loss and gain remain ubiquitous during brain…
Paola V. Figueroa-Delgado, Shaul Yogev
Neuronal remodeling is crucial for proper nervous system development and function, and can be initiated by developmental programs, activity-dependent mechanisms, or stress. Despite significant advances, the underlying mechanisms that govern this process remain poorly understood. Here, we adapted C. elegans IL2 sensory…
Shuo Chen, Boxiao Liu, Haihang You
Spiking Neural Networks (SNNs) have gained considerable attention due to the energy-efficient and multiplication-free characteristics. The continuous growth in scale of deep SNNs poses challenges for model deployment. Network pruning reduces hardware resource requirements of model deployment by compressing the network…
Nikos Malakasis, Spyridon Chavlis, Panayiota Poirazi
While artificial machine learning systems achieve superhuman performance in specific tasks such as language processing, image and video recognition, they do so use extremely large datasets and huge amounts of power. On the other hand, the brain remains superior in several cognitively challenging tasks while operating…
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Researching the EEEV virus is challenging due to the virus's high lethality and significant risk. This study employed bioinformatics methods for domain search to investigate the pathogenesis and infection process of the EEEV virus P protein. The results demonstrated that the EEEV virus P protein contains domains that…