13 papers · ranked by Valyu relevance
Cédric Maurange
The developing central nervous system (CNS) is particularly prone to malignant transformation, but the underlying mechanisms remain unresolved. However, periods of tumor susceptibility appear to correlate with windows of increased proliferation, which are often observed during embryonic and fetal stages and reflect…
Yen-Chung Chen, Nikolaos Konstantinides
The nervous system is one of the most sophisticated animal tissues, consisting of thousands of interconnected cell types. How the nervous system develops its diversity from a few neural stem cells remains a challenging question. Spatial and temporal patterning mechanisms provide an efficient model through which…
Andreas Sagner, Isabel Zhang, Thomas Watson, Jorge Lazaro + 2 more
The molecular mechanisms that ensure the reproducible generation of neuronal diversity in the vertebrate nervous system are incompletely understood. Here we provide evidence of a temporal patterning program consisting of cohorts of transcription factors expressed in neurons generated at successive developmental…
Jimena Garcia-Guillen, Mahla Ahmadi, Theophilus Frimpong, Iris Seaman + 6 more
How spatial patterns arise during embryonic development is classically explained by the French Flag model, in which cells acquire positional identities by interpreting morphogen concentration thresholds. However, in many developmental systems, spatial patterns instead emerge progressively through temporal programs of…
Guohua Yuan, Zhe Zhao, Xiaoxiang Dong, Xu-Wen Wang + 11 more
In the developing neocortex, a diverse array of neurons with defined types and abundances are systematically generated by a limited population of radial glial progenitors (RGPs) as they undergo successive fate changes. The molecular regulation behind this intricate temporal patterning remains elusive. We undertook…
Andreas Sagner, Isabel Zhang, Thomas Watson, Jorge Lazaro + 3 more
'Manuela Melchionda' 'James Briscoe' 'Claude Desplan'] The molecular mechanisms that produce the full array of neuronal subtypes in the vertebrate nervous system are incompletely understood. Here, we provide evidence of a global temporal patterning program comprising sets of transcription factors that stratifies…
Hailun Zhu, Sihai Dave Zhao, Alokananda Ray, Yu Zhang + 1 more
During development, neural stem cells are temporally patterned to sequentially generate a variety of neural types before exiting the cell cycle. Temporal patterning is well-studied in Drosophila, where neural stem cells called neuroblasts sequentially express cascades of Temporal Transcription Factors (TTFs) to control…
Isabel Zhang, Giulia LM Boezio, Jake Cornwall-Scoones, Thomas Frith + 6 more
The vertebrate neural tube generates a large diversity of molecularly and functionally distinct neurons and glia from a small progenitor pool. While the role of spatial patterning in organising cell fate specification has been extensively studied, temporal patterning, which controls the timing of cell type generation…
Katie H. Long, Justin D. Lieber, Sliman J. Bensmaia
Humans are exquisitely sensitive to the microstructure and material properties of surfaces. In the peripheral nerves, texture information is conveyed via two mechanisms: coarse textural features are encoded in spatial patterns of activation that reflect their spatial layout, and fine features are encoded in highly…
Andrea Lopes, Elia Magrinelli, Ludovic Telley
The complexity of brain structure and function is rooted in the precise spatial and temporal regulation of selective developmental events. During neurogenesis, both vertebrates and invertebrates generate a wide variety of specialized cell types through the expansion and specification of a restricted set of neuronal…
Rebecca M Leech, Stephanie E Chappel, Nicola D Ridgers, Heather A Eicher-Miller + 2 more
'Heather A Eicher-Miller' 'Ralph Maddison' 'Sarah A McNaughton'] Dietary and movement behaviors [physical activity (PA), sedentary behavior (SED), and sleep] occur throughout a 24-h day and involve multiple contexts. Understanding the temporal patterning of these 24-h behaviors and their contextual determinants is key…
Semir Zeki, Oliver J. Hulme, Barrie Roulston, Michael Atiyah + 1 more
'Ernest Greene'] In the work reported here, we set out to study the neural systems that detect predictable temporal patterns and departures from them. We used functional magnetic resonance imaging (fMRI) to locate activity in the brains of subjects when they viewed temporally regular and irregular patterns produced by…
Marcos Rodríguez Regueira, Jesús Daza García, Alfonso Rodríguez-Patón Aradas
The multicellular incoherent feedforward loop (mIFFL) is an extension of the traditional intracellular IFFL gene motif where the interacting nodes no longer need to be genes inside the same cell but can be spatially distributed in different cells. We studied for the first time the spatial computing abilities of these…