11 papers · ranked by Valyu relevance
Giulia de Meijere, Andrea Pugliese, Gerardo Iñiguez, Péter L. Simon + 1 more
Contact tracing is one of the most important control measures deployed during epidemics and pandemics, relying on the identification of contacts of known infected individuals. A network perspective is therefore essential for its accurate modelling. Pairwise models have been used extensively to study contact tracing…
Danny Vu, Andrew Kowalczewski, Sarah D. Burnett, Courtney Sakolish + 4 more
Cardiotoxicity remains a major cause of drug attrition and postmarket withdrawal, yet the vast majority of environmental chemicals to which humans may be exposed remain uncharacterized for cardiotoxicity risk. Human induced pluripotent stem cell (hiPSC)-based testing has been proposed to address this gap. Here, we…
Eli J. Costa, Carolina Rios-Martinez, Cecelia J. Andrews, James E. Ferrell + 1 more
Quantitatively relating transcription factor (TF) input to gene expression output is central to understanding mammalian gene regulation and essential for designing predictable synthetic expression systems. However, even minimal synthetic systems often exhibit unexplained behaviors. In a widely used inducible mammalian…
Sarah A. Kemp, Sauro Salomoni, Pierre‐Louis Bazin, Luke Pash + 2 more
Action cancellation involves the termination of planned or ongoing movement, likely initiated in the cortex by the pre-supplementary motor area (preSMA) and inferior frontal gyrus (IFG). It is frequently examined using the stop-signal task; electromyography (EMG) studies have shown action cancellation (in stop trials)…
Cristiano Ialongo
Title: Graphical abstract
Seonghyeon Kim, Jaesik Yang, Sung Kwang Hong, M. Ercan Altinsoy
Motion sickness is an important challenge for the acceptance of autonomous vehicles. Although the Motion Sickness Susceptibility Questionnaire (MSSQ) is widely used, it relies on retrospective self-report and does not directly capture vestibular characteristics. This study examined the association between the…
Megan Sholomiski, Victor Yon, Franziska Mudlaff, Aparna Suvrathan
The cerebellum supports a wide range of motor and non-motor behaviors, yet the specific cerebellar regions and neuronal populations underlying this functional diversity remain poorly understood. Here, we mapped patterns of immediate early gene activation in the cerebellar cortex during the accelerating rotarod task, an…
Yoshitaka Nakayama, Giorgos Hiotis, Thomas Walz
The function and gating mechanism of Escherichia coli mechanosensitive channel of small conductance (EcMscS) is well understood, but it is unknown whether MscS homologs in other bacteria function the same way. Here, we show that the MscS homolog from Corynebacterium glutamicum (CgMscS) opens at a much higher membrane…
Alice Bradford, Stefan Bidula, Laszlo Fabian, Derek Warren
Cardiovascular disease involves coordinated remodelling across multiple biological processes. Gene-level signatures vary substantially between studies because different combinations of genes can support similar biological processes. Pathway-level analyses can provide more stable representations of these processes but…
Md. Zahid Hasan, Kazi Md Azman Hossain, Mohammad Anwar Hossain, Md Obaidul Haque + 3 more
KT is being administered three times weekly over 8 weeks. Before the application, the skin is being cleansed, and participants are being positioned side-lying with the hip extended and the knee flexed at 60°. An I-shaped tape is being applied from the rectus femoris origin, with a Y-shaped tape applied proximal to the…
Dianzhuo Wang, Qian Xu, Arjun Banerjee, Rishi Jain + 7 more
Inferring biological function from experimental data is central to understanding emerging pathogens and developing effective countermeasures, yet interpreting these data remains slow and expert-intensive. AI agents could help accelerate this process by reasoning across sequence, structural, and biophysical evidence. We…