15 papers · ranked by Valyu relevance
John-Antonio Argyriadis, Yang-Hui He, Vishnu Jejjala, Djordje Minic
We study the dynamics of genetic code evolution. The algorithm of Vetsigian et al. [1] provides a solution that is both optimal and universal. We reproduce and analyze the algorithm as a dynamical system. All the parameters used in the model are varied to assess their impact on achieving universality. We show that by…
Xiaolong Wang, Quanjiang Dong, Gang Chen, Jianye Zhang + 8 more
Frameshifted coding genes yield truncated and dysfunctional peptides. Frameshift protein sequences encoded by the alternative reading frames of a coding gene have been considered as meaningless. And frameshift mutations have been considered as utterly harmful and of little or no importance for the molecular evolution…
Jia Lu, Ryan Tsoi, Nan Luo, Yuanchi Ha + 8 more
Dynamical systems often generate distinct outputs according to different initial conditions, and one can infer the corresponding input configuration given an output. This property captures the essence of information encoding and decoding. Here, we demonstrate the use of self-organized patterns, combined with machine…
Simone Giannerini, Alberto Danielli, Diego Luis Gonzalez, Greta Goracci
Circular codes represent a form of coding allowing detection/correction of frameshift errors. Building on recent theoretical advances on circular codes, we provide evidence that protein coding sequences exhibit in-frame circular code marks, that are absent in introns and are intimately linked to the keto-amino…
Pawel M. Mordaka, Kitty Clouston, Jing Cui, Andre Holzer + 3 more
Genome scale engineering has enabled codon compression of the universal genetic code of up to three codons in E. coli, providing the means for genetic code expansion. To go much beyond this number, smaller and simpler genetic systems are needed to avoid significant technical challenges. Chloroplast genomes offer…
Sawsan Wehbi, Nhan Ly-Trong, Andrew Wheeler, Bui Quang Minh + 2 more
We evaluate whether tryptophan (W), widely thought to be the last of the 20 canonical amino acids added to the genetic code, was already present in the Last Universal Common Ancestor (LUCA). We reconstruct the evolutionary history of tryptophanyl-tRNA synthetase (WRS), the enzyme that attaches W to its tRNA, and the…
Tapan Kumar Mohanta, Yugal Kishore Mohanta, Ahmed Al-Harrasi, Nanaocha Sharma
The chloroplast genome of 5959 species was analyzed to construct the anticodon table of the chloroplast genome. Analysis of the chloroplast transfer ribonucleic acid (tRNA) revealed the presence of a putative quadruplet anticodon containing tRNAs in the chloroplast genome. The tRNAs with putative quadruplet anticodons…
Paweł Błażej, Dariusz R. Kowalski, Dorota Mackiewicz, Małgorzata Wnetrzak + 2 more
The standard genetic code (SGC) is the set of rules by which genetic information is translated into proteins, from codons, i.e. triplets of nucleotides, to amino acids. The questions about the origin and the main factor responsible for the present structure of the code are still under a hot debate. Various…
Julie D. Thompson, Raymond Ripp, Claudine Mayer, Olivier Poch + 1 more
The X circular code is a set of 20 trinucleotides (codons) that has been identified in the protein-coding genes of most organisms (bacteria, archaea, eukaryotes, plasmids, viruses). It has been shown previously that the X circular code has the important mathematical property of being an error-correcting code. Thus…
Zhiyan Xi, Lloyd Davis, Kieran Baxter, Ailish Tynan + 2 more
Genetic code expansion in multicellular organisms is currently limited to the use of repurposed amber stop codons. Here we introduce a system for the use of quadruplet codons to direct incorporation of non-canonical amino acids in vivo in an animal, the nematode worm Caenorhabditis elegans. We develop hybrid pyrrolysyl…
Sawsan Wehbi, Andrew Wheeler, Benoit Morel, Bui Quang Minh + 2 more
The current “consensus” order in which amino acids were added to the genetic code is based on potentially biased criteria such as absence of sulfur-containing amino acids from the Urey-Miller experiment which lacked sulfur. Even if inferred perfectly, abiotic abundance might not reflect abundance in the organisms in…
Yusuke Kijima, Daniel Evans-Yamamoto, Hiromi Toyoshima, Nozomu Yachie
Massively parallel DNA sequencing has led to the rapid growth of highly multiplexed experiments in biology. Such experiments produce unique sequencing results that require specific analysis pipelines to decode highly structured reads. However, no versatile framework that interprets sequencing reads for downstream…
Yekaterina Shulgina, Sean R. Eddy
The genetic code has been proposed to be a “frozen accident”, but the discovery of alternative genetic codes over the past four decades has shown that it can evolve to some degree. Since most examples were found anecdotally, it is difficult to draw general conclusions about the evolutionary trajectories of codon…
Rajeev Kohli
Genetic codes assign sixty-four codons to twenty amino acids. These assignments are known to follow certain rules. One question long considered but still unresolved is if these rules are derived from an underlying structure in genetic codes. Knowledge of such structure could facilitate better understanding of the…
Michael Yarus
A near-universal Standard Genetic Code (SGC) implies a single origin for Earthly life. To study this unique event, I compute paths to the SGC, comparing different plausible histories. Notably, SGC-like coding emerges from traditional evolutionary mechanisms, and a superior path can be identified. To objectively measure…