19 papers · ranked by Valyu relevance
Virginia Dignum, Frank Dignum
Agentic AI seeks to endow systems with sustained autonomy, reasoning, and interaction capabilities. To realize this vision, its assumptions about agency must be complemented by explicit models of cognition, cooperation, and governance. This paper argues that the conceptual tools developed within the Autonomous Agents…
Michael Winikoff
In this talk I review where we stand regarding the engineering of multi-agent systems. There is both good news and bad news. The good news is that over the past decade we've made considerable progress on techniques for engineering multi-agent systems: we have good, usable methodologies, and mature tools. Furthermore…
Özge Edebali, Simona Krupčíková, Anna Goellner, Branislav Vrana + 2 more
This review examines the environmental occurrence and fate of aromatic amines (AAs), a group of environmental contaminants with possible carcinogenic and mutagenic effects. AAs are known to be partially responsible for the genotoxic traits of industrial wastewater (WW), and AA antioxidants are acutely toxic to some…
Sara E. Sabbagh, Iago Pinal-Fernandez, Maria Casal-Dominguez, Jemima Albayda + 5 more
We analyzed the prevalence of anti-mitochondrial autoantibodies (AMA) in adult- and juvenile-onset myositis longitudinal cohorts and investigated phenotypic differences in myositis patients with AMA. We screened sera from myositis patients including 619 adult- and 371 juvenile-onset dermatomyositis (DM, JDM)…
Bakani Mark Ncube, Admire Dube, Kim Ward
The vision of the African Medicines Agency (AMA) is to ensure that all Africans have access to affordable medical products that meet internationally recognized standards of quality, safety and efficacy for priority diseases/conditions. The AMA is being established by a treaty which had to be ratified by a minimum of 15…
Jia-Nan Mo, Junqi Su, Jiannan Zhao, Cimarelli Cristina
The recent developments in asymmetric A3 (aldehyde-alkyne-amine) coupling has been summarized in this review. Several interesting modifications of the ligands enabled the highly enantioselective synthesis of chiral propargylamines, which are further used in the construction of nitrogen-containing chiral building…
Madeline Harper, Uma Nudurupati, Riley Workman, Taras Lakoba + 2 more
Using amylin(20-29) as a model system, we demonstrate that Raman spectroscopy can be used to determine the molecular structure of amyloid fibrils. We use polarized Raman spectroscopy measurements and the conformationally-sensitive Amide III3 mode to determine the distributions of peptide backbone amide C=O and CN bond…
Tim Schulte, Antonio Chaves-Sanjuan, Giulia Mazzini, Valentina Speranzini + 13 more
AA amyloidosis is a systemic disease characterized by deposition of misfolded serum amyloid A protein (SAA) into cross-β amyloid in multiple organs in humans and animals. AA amyloidosis occurs at high SAA serum levels during chronic inflammation. The disease can be transmitted horizontally, likely facilitated by…
Priyank Jaini, Johannes Burge
Understanding how nervous systems exploit task relevant properties of sensory stimuli to perform natural tasks is fundamental to the study of perceptual systems. However, there are few formal methods for determining which stimulus properties are most useful for a given task. As a consequence, it is difficult to develop…
Madeline Harper, Uma Nudurupati, Riley Workman, Taras Lakoba + 2 more
Using amylin(20-29) as a model system, we demonstrate that experimental constraints measured by Raman spectroscopy can be used to determine the molecular structure of amyloid fibrils. We employ polarized Raman spectroscopy measurements and the conformationally-sensitive Amide III3 mode to determine the distributions of…
Amit Chaudhary, Anup K. Prasad, Lisandra L. Martin, Ajay Singh Panwar
Post-translational modifications, such as C-terminal amidation, are energetically costly but critical for membrane-active antimicrobial peptides (AMPs). This study examined the impact of C-terminal amidation on uperin 3.5 (U3.5, an amyloid-forming AMP) interactions with POPE:DOPG (3:1) lipid bilayers using molecular…
L. A. Balona, G. Catanzaro, Oyirwoth P. Abedigamba, V. Ripepi + 1 more
'B. Smalley'] We investigate the light variations of 15 Am stars using four years of high-precision photometry from the Kepler spacecraft and an additional 14 Am stars from the K2 Campaign 0 field. We find that most of the Am stars in the Kepler field have light curves characteristic of rotational modulation due to…
Peleg Ragonis-Bachar, Bader Rayan, Eilon Barnea, Yizhaq Engelberg + 2 more
Amyloid protein fibrils and some antimicrobial peptides (AMPs) share biophysical and structural properties. This observation suggests that ordered self-assembly can act as an AMP-regulating mechanism, and, vice versa, that human amyloids play a role in host defense against pathogens, as opposed to their common…
O. V. Kiyaeva, I. S. Izmailov, N.V. Narizhnaya, L.G. Romanenko
Star ADS 9173=WDS 14135+5147=Hip 69483 is a complex system. The B component has a spectroscopic companion, whose orbit with a period of 4.9 years has been known since 1986. The Gaia telescope has detected a distant faint pair over 100" away from the bright AB pair. In our article, we study the movement in a bright pair…
N. F. W. Ligterink, A. Ahmadi, Bijaya. Luitel, A. Coutens + 6 more
'H. Calcutt' 'Łukasz Tychoniec' 'H. Linnartz' 'J. K. Jørgensen' 'R. T. Garrod' 'Jordy Bouwman'] This work aims to constrain the abundances of interstellar amides, by searching for this group of prebiotic molecules in the intermediate-mass protostar Serpens SMM1-a. ALMA observations are conducted toward Serpens SMM1. A…
Authors not listed
Azapeptides feature semicarbazide motifs that can improve the metabolic stability and therapeutic performance of peptides. Azapeptide synthesis suffers however limitations due partly to hydrazide preparation and difficulty in acylating poor semicarbazide nucleophiles. A sustainable and scalable solution-phase method…
Víctor García-Vázquez, Pablo Martínez-Pardo, Alexandru Postole, A. Ken Inge + 1 more
Amines through the Stereospecific Isomerization of α-Chiral Allylic Amines Authors: ['Víctor García-Vázquez' 'Pablo Martínez-Pardo' 'Alexandru Postole' 'A. Ken Inge' 'Belén Martín-Matute'] Chiral γ-branched aliphatic amines are present in a large number of pharmaceuticals and natural products. However, enantioselective…
Sung Soo Ahn, Jin-Ock Kim, Taejun Yoon, Jason Jungsik Song + 3 more
'Yong-Beom Park' 'Sang-Won Lee' 'Sang Gyu Park'] We investigated whether serum aminoacyl-tRNA synthetase-interacting multifunctional protein-1 (AIMP1) could predict severe cases of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) based on the Birmingham vasculitis activity score (BVAS). Sixty-one…
Christin Pohl, Gregory Effantin, Eaazhisai Kandiah, Sebastian Meier + 7 more
Self-assembly and fibril formation play important roles in protein behavior. Amyloid fibrils formation is well-studied due to its role in neurodegenerative diseases and characterized by refolding of the protein into predominant β-sheet form. However, much less is known about the assembly of proteins into other types of…