23 papers · ranked by Valyu relevance
Zhen Wang, Wanqun Zheng, Zhen Chen, Shilun Wu + 3 more
'Ming Cai' 'Heping Cai'] Background Recent evidence increasingly suggests key roles for the tricarboxylic acid cycle and fatty acid metabolism in tumor progression and metastasis. Aconitase 2 (ACO2) is a component of the tricarboxylic acid cycle and represents a key cellular metabolic hub that promotes de novo fatty…
Jiaojiao Sun, Bo Xu, Yijing Chen, Meng Sui + 6 more
Mitochondrial dysfunction during lung ischemia-reperfusion injury (LIRI) contributes to organ dysfunction. Aconitase-2 (ACO2), by enhancing the mitochondrial tricarboxylic acid (TCA) cycle in pulmonary vascular endothelial cells (PVECs), plays a critical role in maintaining cellular energy metabolic homeostasis.…
Steven Sun, Scott William Roy, Noelle Anderson
The Aco2 gene of Schizosaccharomyces pombe was formed by gene fusion between curious partners, namely genes encoding the enzyme aconitase and a mitochondrial ribosomal protein. In addition to a full-length transcript, a truncated mRNA encoding only the N-terminal aconitase domain is produced by polyadenylation at an…
Patrick H. Bradley, Patrick A. Gibney, David Botstein, Olga G. Troyanskaya + 1 more
Isozymes are enzymes that differ in sequence but catalyze the same chemical reactions. Despite their apparent redundancy, isozymes are often retained over evolutionary time for reasons that can be unclear. We find that, in yeast, isozymes are strongly enriched in central carbon metabolism. Using a gene expression…
Amel Yamoune, Marketa Zdarska, Thomas Depaepe, Anna Korytarova + 15 more
The two principal growth regulators cytokinins and ethylene are known to interact in the regulation of plant growth. However, information about underlying molecular mechanism and positional specificity of the cytokinin/ethylene crosstalk in root growth control is scarce. We have identified spatial specificity of…
Jihad Mallat, Mathieu Jozwiak, Nicolás Orozco, Olfa Hamzaoui + 4 more
A fundamental objective of hemodynamic resuscitation is to reverse tissue hypoperfusion and prevent progression to multiorgan failure and death. Conventional tools such as clinical examination, lactate levels, and central or mixed venous oxygen saturation (ScvO₂ and SvO₂, respectively) have intrinsic limitations. These…
Lixuan Jin, Bingxuan Lan, Xinyi Bao, Xiangyuan Xie + 8 more
Unmanned aerial vehicles (UAVs) are increasingly being deployed in logistics, service robotics, and other real-world applications, creating a growing demand for autonomous payload acquisition and delivery. Existing approaches typically assume pre-attached payloads or rely on specialized grippers, leaving versatile…
Dona M. Gunawardana, Francis Kuang, Simranjeet Kaur, Jordan A. P. McIvor + 9 more
Ethylene is a central plant hormone that orchestrates growth, development, senescence, and stress responses. Because it is gaseous, ethylene must be synthesised on demand, yet the catalytic and regulatory mechanisms of its biosynthetic enzyme, 1-aminocyclopropane-1-carboxylic acid oxidase (ACO), remain poorly…
Arnaldo Dubin, Mario O. Pozo, Edward A. Bittner
According to Fick’s principle, the total uptake of (or release of) a substance by tissues is the product of blood flow and the difference between the arterial and the venous concentration of the substance. Therefore, the mixed or central venous minus arterial CO2 content difference depends on cardiac output (CO).…
Arnaldo Dubin, Mario Omar Pozo
As an expression on Fick’s principle, the reduction in cardiac output is associated with a parallel increase in both mixed venoarterial CO2 content difference (Cmv-aCO2) and arterial-mixed venous oxygen content difference (Ca-mvO2). Nevertheless, disproportioned elevations in Cmv-aCO2 compared to those of Ca-mvO2 ensue…
Anatoly Rinberg, Andrew M. Bergman, Daniel P. Schrag, Michael J. Aziz
'Michael J. Aziz'] We describe a new principle — the Alkalinity Concentration Swing (ACS) — for direct air capture of carbon dioxide driven by concentrating an alkaline solution that has been exposed to the atmosphere and loaded with dissolved inorganic carbon. Upon concentration, the partial pressure of carbon dioxide…
Fardad Moshtagh Sisan, Christina Joya, Austin Situ, Scott Silver + 1 more
Traditional gas exchange metrics, such as the alveolar-arterial (A–a) gradient (ΔP), fail to account for systemic oxygen extraction or ventilatory adequacy, thereby limiting their diagnostic precision in complex respiratory or circulatory pathologies. We propose and derive the corrected oxygenation gradient (COG), a…
W. A. van Wijngaarden, P. Ridd, M. Cornell, W. Happer
Fundamental inorganic chemistry shows that increasing concentrations of atmospheric CO2 will have no harmful effect on organisms that live in the natural waters of the Earths, and may well benefit them. Alkalinity and dissolved CO2 give high buffering capacity to most natural waters and minimize the change of pH from…
Xiang Yu, Carmen Otilia Catanescu, Robert Bird, Sriram Satagopan + 2 more
Technological and medical advances over the past few decades epitomize human capabilities. However, the increased life expectancies and concomitant land-use changes have significantly contributed to the release of ~830 gigatons of CO2 into the atmosphere over the last three decades, an amount comparable to the prior…
Ugo Bardi
Levels on Human Health and on the Stability of the Biosphere Authors: ['Ugo Bardi'] Nowadays, the increase of carbon dioxide concentration in the atmosphere is mainly discussed in relation to radiative forcing and the consequent global warming. However, CO2 is a chemically active molecule that plays a vital role in…
Prakashkumar Narasimhamurthy, Yougunn Prakashkumar, Saradha Prakashkumar, Harald Haep + 6 more
We report a highly efficient approach to carbon capture and sequestration via the water catalyzed conversion of basic oxygen steel (BOS) slag and CO2 into CaCO3 and volumetrically stable aggregate for road construction using the Zero-Air-Pollution-Carbon-Capture-Capsule (ZAP-C3) units. The overall transformation is…
Authors not listed
Electrochemically mediated carbon capture (EMCC) offers a promising alternative to thermochemical carbon capture methods due to its higher energy efficiency and the ability to operate under standard conditions. Graphitic electrodes functionalized with redox-active organic (RAO) capture agents offer a unique opportunity…
Kiana Amini, Thomas Cochard, Yan Jing, Jordan Sosa + 6 more
We present two novel experimental techniques designed to quantify the contributions of nucleophilicity-swing and pH-swing mechanisms to carbon capture in the electrochemical aqueous quinone-based CO2 capture process. Through thermodynamic analysis, we elucidate the intricate interplay between these two mechanisms, and…
Authors not listed
The mechanism of Supercapacitive Swing Adsorption (SSA) has been investigated by pH measurements and acid-base titrations of water-extracted, charged activated carbon electrodes at voltage windows varying from 0-0.5V and 0-1.4V. 15%CO2/85%N2 mixtures and pure N2 were used as feed gases. Deionized water extracts from…
Suzi Pugh, Alexander Forse
Carbon dioxide capture is an important greenhouse gas mitigation technology that can help limit climate change. The design of improved capture materials requires a detailed understanding of the mechanisms by which carbon dioxide is bound. Nuclear magnetic resonance (NMR) spectroscopy methods have emerged as a powerful…
Chihjen Lee, Nikki Chen
Carbon monoxide is a colorless, odorless, and poisonous gas, responsible for approximately 100,000 emergency room visits and over 420 deaths in the U.S. each year. Both carbon monoxide and oxygen bind to the ferrous ions in hemoglobin, but carbon monoxide has a significantly higher affinity. Extensive research has been…
Authors not listed
17O NMR spectroscopy is emerging as a powerful probe of the chemistry of CO2 capture and storage materials. However, the technique is currently underutilised, owing to (i) challenging spectral interpretation of quadrupolar nuclei (I = 5/2), especially when multiple oxygen environments are present, and (ii) the need for…
Stefan E. Huber, Silvia Dalnodar, Wolfgang Kausch, S. Kimeswenger + 1 more
'Michael Probst'] Abstract. We calculate harmonic frequencies of the three most abundant carbonic acid conformers. For this, different model chemistries are investigated with respect to their benefits and shortcomings. Based on these results we use perturbation theory to calculate anharmonic corrections at the…