13 papers · ranked by Valyu relevance
Steven Sun, Scott William Roy, Noelle Anderson
The Aco2 gene of Schizosaccharomyces pombe was formed by gene fusion between curious partners, namely genes encoding the enzyme aconitase and a mitochondrial ribosomal protein. In addition to a full-length transcript, a truncated mRNA encoding only the N-terminal aconitase domain is produced by polyadenylation at an…
Patrick H. Bradley, Patrick A. Gibney, David Botstein, Olga G. Troyanskaya + 1 more
Isozymes are enzymes that differ in sequence but catalyze the same chemical reactions. Despite their apparent redundancy, isozymes are often retained over evolutionary time for reasons that can be unclear. We find that, in yeast, isozymes are strongly enriched in central carbon metabolism. Using a gene expression…
Amel Yamoune, Marketa Zdarska, Thomas Depaepe, Anna Korytarova + 15 more
The two principal growth regulators cytokinins and ethylene are known to interact in the regulation of plant growth. However, information about underlying molecular mechanism and positional specificity of the cytokinin/ethylene crosstalk in root growth control is scarce. We have identified spatial specificity of…
Ana Izabel Silva Balbin Villaverde, Rachel Ogle, Peter Lewis, Louise Hetherington + 4 more
After ejaculation, mammalian spermatozoa must undergo a process known as capacitation in order to successfully fertilize the oocyte. Several post-translational modifications occur during capacitation, including sialylation, which despite being limited to a few proteins, seems to be essential for proper sperm-oocyte…
Dona M. Gunawardana, Francis Kuang, Simranjeet Kaur, Jordan A. P. McIvor + 9 more
Ethylene is a central plant hormone that orchestrates growth, development, senescence, and stress responses. Because it is gaseous, ethylene must be synthesised on demand, yet the catalytic and regulatory mechanisms of its biosynthetic enzyme, 1-aminocyclopropane-1-carboxylic acid oxidase (ACO), remain poorly…
V. Agrawal, Xiaole Z. Zhong, J. J. Chen
In the context of fMRI, carbon dioxide (CO_2_) is a well-known vasodilator that has been widely used to monitor and interrogate vascular physiology. Moreover, spontaneous fluctuations in end-tidal carbon dioxide (PETCO_2_) reflects changes in arterial CO_2_ and has been demonstrated as the largest physiological noise…
Fardad Moshtagh Sisan, Christina Joya, Austin Situ, Scott Silver + 1 more
Traditional gas exchange metrics, such as the alveolar-arterial (A–a) gradient (ΔP), fail to account for systemic oxygen extraction or ventilatory adequacy, thereby limiting their diagnostic precision in complex respiratory or circulatory pathologies. We propose and derive the corrected oxygenation gradient (COG), a…
Nan Liu, Lv Wang, Ying Xing, Chen Wang
CO_2_ is one of main byproducts during mitochondrial oxidation. Under the acute occlusion of coronary artery situation, the intra-tissue pCO_2_ of heart could be extremely high. This CO_2_ accumulation will be acutely unloaded and discharged by blood reperfusion. However, the effect of this intra-tissue CO_2_…
Marine Tournissac, Emmanuelle Chaigneau, Sonia Pfister, Ali-Kemal Aydin + 6 more
Neurovascular coupling (NVC), which mediates rapid increases in cerebral blood flow in response to neuronal activation, is commonly used to map brain activation or dysfunction. Here we tested the reemerging hypothesis that CO_2_ generated by neuronal metabolism contributes to NVC. We combined functional ultrasound and…
Paul R.F. Cordero, Katherine Bayly, Pok Man Leung, Cheng Huang + 4 more
Carbon monoxide (CO) is a ubiquitous atmospheric trace gas produced by natural and anthropogenic sources. Some aerobic bacteria can oxidize atmospheric CO and, collectively, they account for the net loss of ~250 teragrams of CO from the atmosphere each year. However, the physiological role, genetic basis, and…
Yongfeng Xu, Ying Teng, Jing Liao, Pok Man Leung + 11 more
Carbon monoxide (CO) is both a potent poison for many aerobic organisms and a desirable energy source for diverse microorganisms. Atmospheric emissions of this gas have increased since industrialization and their levels are highly elevated in many urban and natural environments; however, it is unresolved whether…
Chihjen Lee, Nikki Chen
Carbon monoxide is a colorless, odorless, and poisonous gas, responsible for approximately 100,000 emergency room visits and over 420 deaths in the U.S. each year. Both carbon monoxide and oxygen bind to the ferrous ions in hemoglobin, but carbon monoxide has a significantly higher affinity. Extensive research has been…
Xiuli Yang, Yuguo Li, Zhiliang Wei
Hypercapnia challenge with a few percent of carbon dioxide is popularly used in physiological studies to investigate the dynamic vascular properties. A typical hypercapnia experiment can be divided into four phases: baseline (regular air), transition (CO_2_ enriched), hypercapnia (CO_2_ enriched), and recovery (regular…