15 papers · ranked by Valyu relevance
Zhen Wang, Wanqun Zheng, Zhen Chen, Shilun Wu + 3 more
'Ming Cai' 'Heping Cai'] Background Recent evidence increasingly suggests key roles for the tricarboxylic acid cycle and fatty acid metabolism in tumor progression and metastasis. Aconitase 2 (ACO2) is a component of the tricarboxylic acid cycle and represents a key cellular metabolic hub that promotes de novo fatty…
Jiaojiao Sun, Bo Xu, Yijing Chen, Meng Sui + 6 more
Mitochondrial dysfunction during lung ischemia-reperfusion injury (LIRI) contributes to organ dysfunction. Aconitase-2 (ACO2), by enhancing the mitochondrial tricarboxylic acid (TCA) cycle in pulmonary vascular endothelial cells (PVECs), plays a critical role in maintaining cellular energy metabolic homeostasis.…
Marie Anne-Catherine Neumann, Dajana Grossmann, Simone Schimpf-Linzenbold, Dana Dayan + 14 more
'Simone Schimpf-Linzenbold' 'Dana Dayan' 'Katarina Stingl' 'Reut Ben-Menachem' 'Ophry Pines' 'François Massart' 'Sylvie Delcambre' 'Jenny Ghelfi' 'Jill Bohler' 'Tim Strom' 'Amit Kessel' 'Abdussalam Azem' 'Ludger Schöls' 'Anne Grünewald' 'Bernd Wissinger' 'Rejko Krüger'] ACO2 is a mitochondrial protein, which is…
Miao Hu, Yi You, Yao Li, Shiyi Ma + 7 more
Bombyx mori nucleopolyhedrovirus (BmNPV) is a specific pathogen of Bombyx mori that can significantly impede agricultural development. Accumulating evidence indicates that the viral proliferation in the host requires an ample supply of energy. However, the correlative reports of baculovirus are deficient, especially on…
Zhi Yang, Liang Ma, Yidian Fu, Xiaoyu He + 5 more
Histidine phosphorylation, the neglected but vital phosphoproteome, is a reversible posttranslational modification catalyzed by histidine kinases and erased by phosphohistidine (pHis) phosphatases (e.g., LHPP). Traditional types of phosphorylation have been implicated with the deadliest adult ocular tumor uveal…
Jihad Mallat, Mathieu Jozwiak, Nicolás Orozco, Olfa Hamzaoui + 4 more
A fundamental objective of hemodynamic resuscitation is to reverse tissue hypoperfusion and prevent progression to multiorgan failure and death. Conventional tools such as clinical examination, lactate levels, and central or mixed venous oxygen saturation (ScvO₂ and SvO₂, respectively) have intrinsic limitations. These…
Zhonghua Wang, Xuebiao Wei, Tiehe Qin, Shenglong Chen + 7 more
'Xiaolong Liao' 'Weixin Guo' 'Peihang Hu' 'Yan Wu' 'Jie Li' 'Youwan Liao' 'Shouhong Wang'] Background: Bloodstream infection (BSI) are prone to circulation disorders, which portend poor outcome. The central venous-to-arterial carbon dioxide difference (Pcv-aCO2) is a biomarker for circulation disorders, but the…
Arnaldo Dubin, Mario O. Pozo, Edward A. Bittner
According to Fick’s principle, the total uptake of (or release of) a substance by tissues is the product of blood flow and the difference between the arterial and the venous concentration of the substance. Therefore, the mixed or central venous minus arterial CO2 content difference depends on cardiac output (CO).…
Arnaldo Dubin, Mario Omar Pozo, Javier Hurtado
The central venous minus arterial carbon dioxide pressure to arterial minus central venous oxygen content ratio (Pcv-aCO2/Ca-cvO2) has been proposed as a surrogate for respiratory quotient and an indicator of tissue oxygenation. Some small observational studies have found that a Pcv-aCO2/Ca-cvO2 > 1.4 was associated…
Arnaldo Dubin, Mario Omar Pozo
As an expression on Fick’s principle, the reduction in cardiac output is associated with a parallel increase in both mixed venoarterial CO2 content difference (Cmv-aCO2) and arterial-mixed venous oxygen content difference (Ca-mvO2). Nevertheless, disproportioned elevations in Cmv-aCO2 compared to those of Ca-mvO2 ensue…
Natalia Danek, Stefano Nava
Background: Carbon dioxide (CO2) is traditionally regarded as a metabolic by-product; however, growing evidence indicates that it plays an active regulatory role across multiple physiological systems. Acute hypercapnia elicits respiratory, cardiovascular, metabolic, immune, and neurocognitive responses, some of which…
Akira Umeda, Masahiro Ishizaka, Akane Ikeda, Kazuya Miyagawa + 8 more
'Atsumi Mochida' 'Hiroshi Takeda' 'Kotaro Takeda' 'Isato Fukushi' 'Yasumasa Okada' 'David Gozal' 'Vincenzo Spagnolo' 'Jesús M. Corres'] In the field of respiratory clinical practice, the importance of measuring carbon dioxide (CO2) concentrations cannot be overemphasized. Within the body, assessment of the arterial…
Arnaldo Dubin, Gonzalo Ferrara, Vanina Siham Kanoore Edul, Enrique Martins + 5 more
'Enrique Martins' 'Héctor Saúl Canales' 'Carlos Canullán' 'Gastón Murias' 'Mario Omar Pozo' 'Elisa Estenssoro'] Background The identification of anaerobic metabolism in critically ill patients is a challenging task. Observational studies have suggested that the ratio of venoarterial PCO2 (Pv-aCO2) to arteriovenous…
Amilkar Almanza-Hurtado, Camilo Polanco Guerra, María Cristina Martínez-Ávila, Diana Borré-Naranjo + 2 more
'María Cristina Martínez-Ávila' 'Diana Borré-Naranjo' 'Tomás Rodríguez-Yanez' 'Carmelo Dueñas-Castell'] Acute hypercapnic ventilatory failure is becoming more frequent in critically ill patients. Hypercapnia is the elevation in the partial pressure of carbon dioxide (PaCO2) above 45 mmHg in the bloodstream. The…
Rutger van der Schrier, Monique van Velzen, Margot Roozekrans, Elise Sarton + 4 more
'Elise Sarton' 'Erik Olofsen' 'Marieke Niesters' 'Chantal Smulders' 'Albert Dahan'] Background: Due the increasing need for storage of carbon dioxide (CO2) more individuals are prone to be exposed to high concentrations of CO2 accidentally released into atmosphere, with deleterious consequences. Methods: We tested the…