23 papers · ranked by Valyu relevance
Jordi Martorell-Marugán, Raúl López-Domínguez, Adrián García-Moreno, Daniel Toro-Domínguez + 12 more
Autoimmune diseases are heterogeneous pathologies with difficult diagnosis and few therapeutic options. In the last decade, several omics studies have provided significant insights into the molecular mechanisms of these diseases. Nevertheless, data from different cohorts and pathologies are stored independently in…
Diogo L. M. Souza, Enrique C. Gabrick, Paulo R. Protachevicz, Fernando S. Borges + 5 more
'Fernando S. Borges' 'José Trobia' 'Kelly C. Iarosz' 'Antônio M. Batista' 'Iberê L. Caldas' 'E. K. Lenzi'] The description of neuronal activity has been of great importance in neuroscience. In this field, mathematical models are useful to describe the electrophysical behaviour of neurons. One successful model used for…
Prithviraj Mukherjee, Federico Nebuloni, Hua Gao, Jian Zhou + 1 more
'Ian Papautsky'] Fabrication of microfluidic devices by soft lithography is by far the most popular approach due to simplicity and low cost. In this approach PDMS (polydimethylsiloxane) is cast on a photoresist master to generate replicas that are then sealed against glass slides using oxygen plasma. In this work, we…
Yule Wang, Osman Taylan, Abdulaziz S. Alkabaa, Ijaz Ahmad + 6 more
'Elsayed Tag-Eldin' 'Ehsan Nazemi' 'Mohammed Balubaid' 'Hanan Saud Alqabbaa' 'Holger Fröhlich' 'Claudio R. Mirasso'] Simple Summary The brain is an incredibly complex system possessing outstanding abilities to perform difficult tasks through a vast number of densely interconnected neurons. Aimed at discovering the…
Syed Ahmed Aamir, Paul Müller, Gerd Kiene, Laura Kriener + 4 more
'Yannik Stradmann' 'Andreas Grübl' 'Johannes Schemmel' 'Karlheinz Meier'] Abstract—Here we describe a multi-compartment neuron circuit based on the Adaptive-Exponential I&F (AdEx) model, developed for the second-generation BrainScaleS hardware. Based on an existing modular Leaky Integrate and Fire (LIF) architecture…
Jennifer S. Goldman, Lionel Kusch, Bahar Hazal Yalçinkaya, Damien Depannemaecker + 3 more
Hallmarks of neural dynamics during healthy human brain states span spatial scales from neuromodulators acting on microscopic ion channels to macroscopic changes in communication between brain regions. Developing a scale-integrated understanding of neural dynamics has therefore remained challenging. Here, we perform…
Jordi Martorell-Marugán, Raúl López-Domínguez, Adrián García-Moreno, Daniel Toro-Domínguez + 12 more
'Daniel Toro-Domínguez' 'Juan Antonio Villatoro-García' 'Guillermo Barturen' 'Adoración Martín-Gómez' 'Kevin Troule' 'Gonzalo Gómez-López' 'Fátima Al-Shahrour' 'Víctor González-Rumayor' 'María Peña-Chilet' 'Joaquín Dopazo' 'Julio Sáez-Rodríguez' 'Marta E. Alarcón-Riquelme' 'Pedro Carmona-Sáez'] Background Autoimmune…
Jennifer S. Goldman, Lionel Kusch, David Aquilue, Bahar Hazal Yalçınkaya + 5 more
'Bahar Hazal Yalçınkaya' 'Damien Depannemaecker' 'Kevin Ancourt' 'Trang-Anh E. Nghiem' 'Viktor Jirsa' 'Alain Destexhe'] Hallmarks of neural dynamics during healthy human brain states span spatial scales from neuromodulators acting on microscopic ion channels to macroscopic changes in communication between brain…
David Aquilué-Llorens, Jennifer S. Goldman, Alain Destexhe
Biophysically-grounded whole-brain models were built recently using tractography data to interconnect multiple mesoscopic models, which can simulate the dynamics of neuronal populations with only a few equations. Mean-field models of neural populations, specifically the Adapting AdEx mean-field, was used for this…
Damien Depannemaecker, Tomasz Górski, Alain Destexhe
The intrinsic electrophysiological properties of single neurons can be described by a broad spectrum of models, from the most realistic Hodgkin-Huxley type models with numerous detailed mechanisms to the phenomenological models. The Adaptive Exponential integrate-and-fire (AdEx) model has emerged as a convenient…
Mario El Khoury, Tobias Winterstein, Wadim Weber, Viktor Stein + 2 more
'Helmut F. Schlaak' 'Gerhard Thiel'] Abstract Planar lipid bilayers constitute a versatile method for measuring the activity of protein channels and pores on a single molecule level. Ongoing efforts attempt to tailor this method for detecting biomedically relevant target analytes or for high-throughput screening of…
Emre Baspinar, Gloria Cecchini, Michael DePass, Marta Andujar + 5 more
We propose a new AdEx mean-field framework to model two networks of excitatory and inhibitory neurons, representing two cortical columns. The columns are interconnected with excitatory connections contacting both Regularly Spiking (excitatory) and Fast Spiking (inhibitory) cells. The model is biophysically plausible…
weiwei zhang
The Adaptive Exponential Integrate-and-Fire (AdEx) model is a simplified framework that effectively characterizes neuronal electrical activity. The aim of this paper is to employ phase plane analysis to systematically investigate diverse firing patterns generated by the AdEx model under varying parametric conditions.…
Yongheng Liang, Hejun Wu, Haitao Wang, H. Cai
Learning Authors: ['Yongheng Liang' 'Hejun Wu' 'Haitao Wang' 'H. Cai'] Credit assignment is a core problem that distinguishes agents' marginal contributions for optimizing cooperative strategies in multi-agent reinforcement learning (MARL). Current credit assignment methods usually assume synchronous decisionmaking…
Caglar Cakan, Klaus Obermayer
Electrical stimulation of neural systems is a key tool for understanding neural dynamics and ultimately for developing clinical treatments. Many applications of electrical stimulation affect large populations of neurons. However, computational models of large networks of spiking neurons are inherently hard to simulate…
Lionel Kusch, Damien Depannemaecker, Alain Destexhe, Viktor Jirsa
The study of brain activity spans diverse scales and levels of description, and requires the development of computational models alongside experimental investigations to explore integrations across scales. The high dimensionality of spiking networks presents challenges for understanding their dynamics. To tackle this…
Xiaolong Zhang, Jiajun Du, Fan Liao, Hao Su + 2 more
Understanding intermolecular interactions between Lewis acid and base pairs is of fundamental importance in predicting non-covalent bonding and chemical reactivity. Here we show that an acridinium derivative, a Lewis acid, exhibits various degrees of interactions with Lewis bases of increasing nucleophilicity…
Stephanie Heard, Jaclyn Winter
The adenylation reaction has been a subject of scientific intrigue since it was first recognized as essential to many biological processes, including the homeostasis and pathogenicity of some bacteria and the activation of amino acids for protein synthesis in mammals. Several foundational studies on adenylation (A)…
Kristian Steen Frederiksen, Camilla Steen Jensen, Peter Høgh, Robert Gergelyffy + 9 more
'Robert Gergelyffy' 'Gunhild Waldemar' 'Birgitte Bo Andersen' 'Hanne Gottrup' 'Karsten Vestergaard' 'Lene Wermuth' 'Helle Bach Søndergaard' 'Finn Sellebjerg' 'Steen Gregers Hasselbalch' 'Anja Hviid Simonsen'] Introduction Aerobic exercise has been shown to modify Alzheimer pathology in animal models, and in patients…
Yoshiki Chazono, K. Yoshida, Kazuyuki Ogata
Background: Deuteron-induced one-neutron transfer reactions have been used to extract single-particle properties of nuclei, and the adiabatic (AD) approximation is often used to simply treat the deuteron breakup states. Purpose: The primary goal is to examine the validity of the AD approximation for the (d, p) reaction…
Authors not listed
In this computational study, the adsorption of alkali metal atoms on Pt(111) is studied by periodic electronic structure calculations based on density functional theory. This study is motivated by the promoting role of alkali metal atoms in several reactions in electro- and heterogeneous catalysis. In a systematic…
Rumiana Tenchov, Janet Sasso, Qiongqiong Angela Zhou
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and impaired daily functioning. The pathology of AD is marked by the accumulation of amyloid-beta plaques and tau protein tangles in brain, along with neuroinflammation and synaptic dysfunction. Genetic…
Authors not listed
Adenylate kinases (AKs) are a family of conserved phosphotransferases essential for maintaining cellular energy homeostasis through the interconversion of adenine nucleotides. Recent studies have revealed that AKs contribute to various pathophysiological processes beyond energy metabolism, particularly in inflammation…