27 papers · ranked by Valyu relevance
Louis Papageorgiou, Eleni Mangana, Eleni Papakonstantinou, Io Diakou + 8 more
TANK binding kinase 1 protein (TBK1) is a kinase that belongs to the IκB (IKK) family. TBK1, also known as T2K, FTDALS4, NAK, IIAE8 and NF-κB, is responsible for the phosphorylation of the amino acid residues Serine and Threonine. This enzyme is involved in various key biological processes, including interferon…
Baykal Gulcin, Erkal Burcin, Vural Korkut Senay
Non-coding, single-stranded RNA molecules known as microRNAs (miRNAs) regulate gene expression via mRNA degradation after transcription. As a result, they affect a number of pathways in organisms that are important for both health and disease. miRNAs can be utilized as potential diagnostic, prognostic, and therapeutic…
Authors not listed
Amyotrophic Lateral Sclerosis (ALS) Awareness Month - May 2015 May is Amyotrophic Lateral Sclerosis (ALS) Awareness Month. ALS, also known as Lou Gehrig’s disease, is a progressive, fatal, neurodegenerative disorder of the upper and lower motor neurons. The etiology of ALS is not well understood, and no cure exists.…
Arun Pal, Dajana Grossmann, Hannes Glaß, Vitaly Zimyanin + 10 more
Amyotrophic Lateral Sclerosis (ALS) is the most common motor neuron disease leading to death within 2-5 years. Currently available drugs can only slightly prolong survival. Despite the progress that has been achieved in unravelling the molecular mechanisms of the disease so far, the underlying pathophysiology is not…
Serveh Kamrava, Ali Sahimi, Justin Ichida, Muhammad Sahimi
We propose a machine learning (ML) method to classify ALS–causative and non–ALS–causative variants based on 24 variables in five different datasets. The proposed ML method classifies the five datasets with very high accuracy. In particular, it predicts the ALS variants with 100 percent accuracy, while its accuracy for…
Sarah Martin, Ahmad Al Khleifat, Ammar Al-Chalabi
Amyotrophic lateral sclerosis is a neurodegenerative disease predominantly affecting upper and lower motor neurons, resulting in progressive paralysis and death from respiratory failure within 2 to 3 years. The peak age of onset is 55 to 70 years, with a male predominance. The causes of amyotrophic lateral sclerosis…
Riccardo Oggiano, Andrea Pisano, Angela Sabalic, Cristiano Farace + 5 more
'Grazia Fenu' 'Simone Lintas' 'Giovanni Forte' 'Beatrice Bocca' 'Roberto Madeddu'] The present review represents an update about the knowledge of the possible role of Cadmium (Cd) in amyotrophic lateral sclerosis (ALS) initiation and its progression. ALS is a neurodegenerative disease that occurs in adulthood; its…
Andreza Martinez Pozza, Milene Karenine Delamura, Clarissa Ramirez, Nelson Iguimar Valério + 2 more
'Nelson Iguimar Valério' 'Laís Helena Carvalho Marino' 'Neuseli Marino Lamari'] Title: ABSTRACT Amyotrophic Lateral Sclerosis (ALS) is a fatal progressive neurodegenerative disease with multifactorial etiology for which, so far, there is no effective medicinal treatment. However, by means of kinesiotherapy intervention…
Arosh S. Perera Molligoda Arachchige
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive degeneration of the upper and lower motor neurons, which leads to muscle atrophy, spasticity, and ultimately respiratory failure. The etiology of ALS remains unclear, though a combination of genetic and environmental…
Jasmine A. Fels, Jalia Dash, Kent Leslie, Giovanni Manfredi + 1 more
ALS is a rapidly progressive, fatal disorder caused by motor neuron degeneration, for which there is a great unmet therapeutic need. AMX0035, a combination of sodium phenylbutyrate (PB) and taurursodiol (TUDCA, Turso), has shown promising results in early ALS clinical trials, but its mechanisms of action remain to be…
Piplu Bhuiyan, Yutong Yi, Betty Wei, Allen Yan + 2 more
Calcium dysregulation, caused by pathological activation of ryanodine receptors, contributes to motor neuron degeneration, motor dysfunction, and muscle weakness in SOD1-G93A transgenic amyotrophic lateral sclerosis (ALS) mice. This study investigates the therapeutic efficacy of intranasally administered dantrolene…
Teresa Cunha-Oliveira, Daniela Franco Silva, Luis Segura, Inês Baldeiras + 4 more
Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly progressing neurodegenerative disease that affects motor neurons. This disease is associated with oxidative stress especially in mutant superoxide dismutase 1 (mutSOD1) patients. However, less is known for the most prevalent sporadic ALS due to a lack of…
Maxim Vashkevich, Alexander Petrovsky, Yuliya Rushkevich
—On average the lack of biological markers causes a one year diagnostic delay to detect amyotrophic lateral sclerosis (ALS). To improve the diagnostic process an automatic voice assessment based on acoustic analysis can be used. The purpose of this work was to verify the sutability of the sustain vowel phonation test…
Loukas Ilias, Dimitris Askounis
—Amyotrophic Lateral Sclerosis (ALS) constitutes a progressive neurodegenerative disease with varying symptoms, including decline in speech intelligibility. Existing studies, which recognize dysarthria in ALS patients by predicting the clinical standard ALSFRS-R, rely on feature extraction strategies and the design of…
Arielle Kasindi, Kathy Jo Carstarphen
Background: Amyotrophic lateral sclerosis (ALS), a fatal neuromuscular disease, affects the motor tracts and anterior horn cells of the spinal cord, causing both upper and lower motor neuron dysfunction. ALS typically involves progressive peripheral weakness and mobility issues. Case Report: An African American male in…
Dongxiang Yuan, Shishi Jiang, Renshi Xu
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the central nervous system. Despite a large number of studies, the current prognosis of ALS is still not ideal. This article briefly describes the clinical features including epidemiology, genetic structure and clinical manifestations, as well…
Rumiana Tenchov, Janet Sasso, Qiongqiong Angela Zhou
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and impaired daily functioning. The pathology of AD is marked by the accumulation of amyloid-beta plaques and tau protein tangles in brain, along with neuroinflammation and synaptic dysfunction. Genetic…
Ijaz Bukhari
Brain is the central part of the human nervous system and any abnormality caused by any disease can lead to complete failure of human structural function. Alzheimer, an old age disease of people over 65 years [1] causes problems with memory, thinking and behavior. This disease progresses very slow and its…
Rumiana Tenchov, Janet Sasso, Xinmei Wang, Qiongqiong Angela Zhou
Aging is a dynamic, time-dependent process characterized by a gradual accumulation of cell damage. Continual functional decline in the intrinsic ability of living organisms to accurately regulate homeostasis leads to increased susceptibility and vulnerability to diseases. Anti-aging research has a long history…
Authors not listed
The efficiency of solar-to-energy conversion in semiconductors is limited by charge carrier recombination, often via defect-induced gap states. Although some materials exhibit an intrinsic defect tolerance that avoids fast recombination channels, there are few examples for metal oxides. We investigate the…
Shrish Pellakur, Nelly Elsayed, Zag ElSayed, Murat Özer
Alzheimer's disease is a degenerative brain disease. Being the primary cause of Dementia in adults and progressively destroys brain memory. Though Alzheimer's disease does not have a cure currently, diagnosing it at an earlier stage will help reduce the severity of the disease. Thus, early diagnosis of Alzheimer's…
Janet Sasso, Barbara Ambrose, Rumiana Tenchov, Ruchira Datta + 3 more
In the last decade, there has been a shift in research, clinical development, and commercial activity to exploit the many roles of RNA in physiology for use in medicine. With the rapid success in the development of lipid-RNA nanoparticles for mRNA vaccines against COVID-19 and with several approved RNA-based drugs, RNA…
Authors not listed
The neurodegenerative illness Alzheimer's disease causes 70% of cases of dementia, leading to the impairment of behavioral and cognitive functions such as language, attention, memory, judgment, and reasoning. The disease is caused by the buildup of amyloid fibrils in brain neurons. Recently, in 2023, a new type of…
M.J. Khatun, Md. Manowarul Islam, Habibur Rahman Rifat, Md. Shamim Bin Shahid + 2 more
'Md. Shamim Bin Shahid' 'Md. Alamin Talukder' 'Md Ashraf Uddin'] Abstract—Brain-related diseases are more sensitive than other diseases due to several factors, including the complexity of surgical procedures, high costs, and other challenges. Alzheimer's disease is a common brain disorder that causes memory loss and…
Vincent Henry, Ivan Moszer, Olivier Dameron, Marie‐Claude Potier + 2 more
'Martin Hofmann‐Apitius' 'Olivier Colliot'] > Abstract. Alzheimer's disease (AD) pathophysiology is still imperfectly understood and current paradigms have not led to curative outcome. Omics technologies offer great promises for improving our understanding and generating new hypotheses. However, integration and…
Authors not listed
The accumulation of beta-amyloid (Aβ) oligomers is a critical hallmark for different neurodegenerative conditions, including Alzheimer's disease. The short peptide KLVFF, derived from the central hydrophobic domain of Aβ, binds to Aβ oligomers and interferes with Aβ aggregation. However, the underlying molecular…
Yu Shen
Alzheimer's disease (AD) is a neurodegenerative disorder that affects millions of people worldwide. Early screening is crucial to prevent potential damages, and researchers are exploring alternative approaches such as multiplexed assays and emerging technologies such as microfluidics, nanotechnology, and biosensors.…