22 papers · ranked by Valyu relevance
Thilini R Fernando, Norma I Rodriguez-Malave, Dinesh S Rao
MicroRNAs are small RNA molecules that regulate gene expression and play critical roles in B cell development and malignancy. miRNA expression is important globally, as B cell specific knockouts of Dicer show profound defects in B cell development; and is also critical at the level of specific miRNAs. In this review…
Stephanie G. Yi, Ahmed Osama Gaber, Wenhao Chen
The transcriptional regulation of B-cell response to antigen stimulation is complex and involves an intricate network of dynamic signals from cytokines and transcription factors propagated from T-cell interaction. Long-term alloimmunity, in the setting of organ transplantation, is dependent on this B-cell response…
Marina Bakardjieva, Jan Stuchlý, Ondřej Pelák, Marjolein Wentink + 8 more
Detailed knowledge of the human B-cell development is crucial for proper interpretation of inborn errors of immunity and for malignant diseases. It is of interest to understand the kinetics of protein expression changes during the B cell development, but also to properly interpret the major and possibly alternative…
Jill de Mol, Johan Kuiper, Dimitrios Tsiantoulas, Amanda C. Foks
Aging is considered to be an important risk factor for several inflammatory diseases. B cells play a major role in chronic inflammatory diseases by antibody secretion, antigen presentation and T cell regulation. Different B cell subsets have been implicated in infections and multiple autoimmune diseases. Since aging…
Jorge Gómez-Manríquez, Jorge Hernández-Bello, José Francisco Muñoz-Valle, Sonia Sifuentes-Franco + 2 more
'José Francisco Muñoz-Valle' 'Sonia Sifuentes-Franco' 'Omar Graciano-Machuca' 'José Javier Morales-Núñez'] B lymphocytes are essential elements of the adaptive immune response, performing critical functions such as antigen presentation, cytokine secretion, and antibody production. Their development follows a tightly…
Xiujia Yang, Haipei Tang, Chunhong Lan, Weiting He + 6 more
The development and maturation of B lymphocytes involve intricate orchestrated processes, where dedicated gene regulations (GR) take place within specific microenvironments shaped by both extracellular matrix and neighboring cells. Despite extensive investigations aimed at deepening our comprehension of these…
Roser Vilarrasa-Blasi, Seungjoon Kim, J. Patrick Pett, Jakov Korzhenevich + 25 more
In humans, the bone marrow becomes the primary site for B lymphopoiesis during the second trimester of pregnancy and continues throughout life. Prenatal and adult B cell progenitors play distinct roles in the aetiology and pathology of paediatric and adult hematopoietic malignancies, though the molecular drivers of…
Alec J. Wishnie, Tzippora Chwat-Edelstein, Mary Attaway, Bao Q. Vuong
'Bao Q. Vuong'] B cells produce high-affinity immunoglobulins (Igs), or antibodies, to eliminate foreign pathogens. Mature, naïve B cells expressing an antigen-specific cell surface Ig, or B cell receptor (BCR), are directed toward either an extrafollicular (EF) or germinal center (GC) response upon antigen binding. B…
Daisy H. Luff, Lesley Vanes, Stefan Boeing, Victor L. J. Tybulewicz
The mature B cell compartment consists of follicular (FO) and marginal zone (MZ) B cells, which develop from transitional type 2 (T2) B cells and mount T-dependent and T-independent antibody responses, respectively. TACI, a member of the TNF receptor superfamily, is expressed on all mature B cells, with highest levels…
Mikala JoAnn Willett, Christopher McNees, Sukriti Sharma, Anna Minh Newen + 6 more
Autoreactive B cells generated during B cell development are inactivated by clonal deletion, receptor editing or anergy. Up to 97% of immature B cells appear to die before completing maturation, but the anatomic sites and reasons underlying this massive cell loss are not fully understood. Here, we directly quantitated…
Salvador Chulián, Alvaro A. Martinez, Anna Marciniak‐Czochra, Thomas Stiehl + 6 more
'Thomas Stiehl' 'Cristina Blázquez Goñi' 'Juan Francisco Rodríguez Gutiérrez' 'Manuel Ramı́rez' 'Ana Castillo Robleda' 'Vı́ctor M. Pérez-Garcı́a' 'M. Rosa'] Haematopoiesis is the process of generation of blood cells. Lymphopoiesis generates lymphocytes, the cells in charge of the adaptive immune response. Disruptions…
Tamás Szabados, Csaba Kerepesi, Tibor Bakács
Our main purpose is to compare classical nonself-centered, two-signal theoretical models of the adaptive immune system with a novel, self-centered, one-signal model developed by our research group. Our model hypothesizes that the immune system of a fetus is capable learning the limited set of self antigens but unable…
Anne Bruun Rovsing, Kenneth Green, Lisbeth Jensen, Ian Helstrup Nielsen + 2 more
B cells are essential in the immune system, driving antibody production, cytokine secretion, and antigen presentation. Studies in mouse models have illuminated key mechanisms underlying B-cell activation, differentiation, class-switch recombination, and somatic hypermutation. However, the extent to which these findings…
Lisa Buchauer, Hedda Wardemann
Germinal centres are anatomically defined lymphoid organ structures that mediate B cell affinity maturation and affect the quality of humoral immune responses. Mathematical models based on differential equations or agent-based simulations have been widely used to deepen our understanding of the cellular and molecular…
Stephen Lindsly, Maya R. Gupta, Alnawaz Rehemtulla, Indika Rajapakse
The mammalian adaptive immune system has evolved over millions of years to become an incredibly effective defense against foreign antigens. The adaptive immune system's humoral response creates plasma B cells and memory B cells, each with their own immunological objectives. The affinity maturation process is widely…
Alexander J Clarke, Thomas Riffelmacher, Daniel Braas, Richard J Cornall + 1 more
Specific metabolic programs are activated by immune cells to fulfil their functional roles, which include adaptations to their microenvironment. B1 B cells are tissue-resident, innate-like B cells. They have many distinct properties, such as the capacity to self-renew and the ability to rapidly respond to a limited…
Rajat Desikan, Rustom Antia, Narendra M. Dixit
The affinity of antibodies (Abs) produced in vivo for their target antigens (Ags) is typically well below the maximum affinity possible. Nearly 25 years ago, Foote and Eisen explained how an 'affinity ceiling' could arise from constraints associated with the acquisition of soluble antigen by B cells. However, recent…
Jacques Banchereau
The description of factor-dependent cytotoxic T-cell lines in the late 1970s transformed T-cell biology (1). Among other events, it led to the cloning of a cDNA encoding IL-2 (2). It also led to the identification of T-cell subsets and formulation of the Th1/Th2 concept in the 80s (3). However, comparable advances in…
Saeed Mahdisoltani, Pranav Murugan, Arup K. Chakraborty, Mehran Kardar
'Mehran Kardar'] A persistent public health challenge is finding immunization schemes that are effective in combating highly mutable pathogens such as HIV and influenza viruses. To address this, we analyze a simplified model of affinity maturation, the Darwinian evolutionary process B cells undergo during immunization.…
Ichwaku Rastogi, Donghwan Jeon, Jena E. Moseman, Anusha Muralidhar + 2 more
'Hemanth K. Potluri' 'Douglas G. McNeel'] B cells have been long studied for their role and function in the humoral immune system. Apart from generating antibodies and an antibody-mediated memory response against pathogens, B cells are also capable of generating cell-mediated immunity. It has been demonstrated by…
Jicun Wang-Michelitsch, Thomas M. Michelitsch
Lymphoid leukemia (LL) and lymphoma are two groups of blood cancers developed from lymphoid cells (LCs). To understand the cause and the mechanism of cell transformation of a LC, we studied the potential sources of cell injuries of LCs and analyzed how DNA changes are generated and accumulate in LCs. I. The DNA changes…
Authors not listed
This paper addresses the challenges in cell line development (CLD), the lengthy and ambiguous clone screening in upstream biopharmaceutical production. Typically, only a small subset of the later stages of CLD data is used for manually selecting lead clones. Addressing this issue, we introduce a multivariate data…