18 papers · ranked by Valyu relevance
Su-Geun Lim, Jae-Kwan Kim, Kyoungho Suk, Won-Ha Lee
Cellular response to stimulation is mediated by meshwork of signaling pathways that may share common signaling adaptors. Here, we present data demonstrating that signaling pathways initiated from the membrane-bound form of B-cell activating factor (BAFF) can crosstalk with lipopolysaccharide (LPS)-induced signaling for…
Michal Rihacek, Julie Bienertova-Vasku, Dalibor Valik, Jaroslav Sterba + 2 more
'Jaroslav Sterba' 'Katerina Pilatova' 'Lenka Zdrazilova-Dubska'] B-cell activating factor (BAFF) is a cytokine and adipokine of the TNF ligand superfamily. The main biological function of BAFF in maintaining the maturation of B-cells to plasma cells has recently made it a target of the first FDA-approved selective BAFF…
Martina Rossi, Carlos Anerillas, Maria Laura Idda, Rachel Munk + 13 more
Senescent cells release a variety of cytokines, proteases, and growth factors collectively known as the senescence-associated secretory phenotype (SASP). Sustained SASP contributes to a pattern of chronic inflammation associated with aging and implicated in many age-related diseases. Here, we investigated the…
Md Ashik Ullah, Fabienne Mackay, Lorraine A. O’Reilly
Simple Summary The ligands BAFF and APRIL and their cognate receptors are critical for the differentiation, survival, and function of B cells and, as such, the maintenance of humoral immunity. The BAFF-APRIL system also modulates, either directly or indirectly, the function of other immune and non-immune cells.…
P J Hengeveld, M J Kersten
Multiple myeloma (MM) is a currently incurable malignancy of plasma cells. Malignant myeloma cells (MMCs) are heavily dependent upon the bone marrow (BM) microenvironment for their survival. One component of this tumor microenvironment, B-Cell Activating Factor (BAFF), has been implicated as a key player in this…
Chan Seok Lim, Jisun Lee, Ji Won Kim, Jie-Oh Lee
We report the cryo-EM structures of clusters of TNF receptor family proteins, TNFR1 and BAFFR. The receptor-ligand complexes were anchored to a flat lipid layer to mimic the membrane-bound state. We observed that the TNFα-TNFR1 complex forms highly ordered binary, bent, trigonal, and linear quadruple clusters of…
Sojin Park, Ju-Won Jang, Eun-Yi Moon
Cell survival is facilitated by the maintenance of mitochondrial membrane potential (MMP). B cell activating factor (BAFF) plays a role in survival, differentiation, and maturation of B cells. In the present study, we examined whether BAFF could attenuate oxidative stress-induced B cell death by the regulation of MMP…
Yu Rebecca Miao, Kaushik Thakker, Can Cenik, Dadi Jiang + 13 more
Recent T Cell therapies have been effective in the treatment of hematological cancers. However, immunotoxicity and treatment relapse pose significant clinical challenges. Here, we revealed distinctive requirement for neutralizing TNF receptor ligands APRIL and BAFF in MM and DLBCL. Furthermore, we investigated the use…
Daisy H. Luff, Lesley Vanes, Stefan Boeing, Victor L. J. Tybulewicz
The mature B cell compartment consists of follicular (FO) and marginal zone (MZ) B cells, which develop from transitional type 2 (T2) B cells and mount T-dependent and T-independent antibody responses, respectively. TACI, a member of the TNF receptor superfamily, is expressed on all mature B cells, with highest levels…
Sara Maia, Marc Pelletier, Jixin Ding, Yen-Ming Hsu + 5 more
'Stephen E. Sallan' 'Sambasiva P. Rao' 'Lee M. Nadler' 'Angelo A. Cardoso' 'Wael El-Rifai'] Despite exhibiting oncogenic events, patient's leukemia cells are responsive and dependent on signals from their malignant bone marrow (BM) microenvironment, which modulate their survival, cell cycle progression, trafficking and…
Matheus Aranguren, Kim Doyon-Laliberté, Mohamed El-Far, Carl Chartrand-Lefebvre + 7 more
Chronic inflammation persists in people living with HIV (PLHIV) despite antiretrovial therapy (ART), and is involved in their premature development of cardiovascular diseases (CVD) such as atherosclerosis. We have previously reported that an excess of “B-cell activating factor” (BAFF), an important molecule for the…
Shu Liu, Guo-Qing Li, Qing-Wei Gu, Jie Wang + 6 more
Breakdown of tolerance and abnormal activation in B cells is an important mechanism in Graves’ disease (GD) pathogenesis. However, the mechanism by which B cells are abnormal differentiated and activated in GD remains elusive. Here, we show that elevated BAFF expression is positively correlated with serum thyroid…
Authors not listed
BML-284 is a cell-permeable small molecule known to act as an agonist of the Wnt signaling pathway. We have previously reported photoswitchable azo derivatives of BML-284 capable of reversible trans–cis isomerization under visible light. Only the cis isomer of these derivatives activates Wnt signaling, offering…
Berkalp A. Doğaner, Lawrence K.Q. Yan, Hyun Youk
- Cells often secrete and sense a signaling molecule to "talk" to each other. Autocrine signaling is one of the main forms of such communication. "Autocrine cell" refers to a cell that secretes a signaling molecule and makes its cognate receptor. - Recent studies have shown that an autocrine cell can communicate with…
Christoph Haag, Julia Erl, Korbinian Helbig, Joachim Wegener + 1 more
Cyclic adenosine monophosphate (cAMP) is one of the most prominent molecules involved in intracellular signaling. As a second messenger, it regulates a plethora of biochemical processes that are essential to keep a cell alive and orchestrates physiological responses to external stimuli. Ever since its discovery, great…
Santosh Manicka, Michael Levin
The field of basal cognition seeks to understand how adaptive, context-specific behavior occurs in non-neural biological systems. Embryogenesis and regeneration require plasticity in many tissue types to achieve structural and functional goals in diverse circumstances. Thus, advances in both evolutionary cell biology…
wenzhong liu, hualan li
Infection with the Zika virus results in severe neurological disease in adults or congenital Zika syndrome in newborns. We employed the domain search strategy to study the Zika virus glycoprotein E in this work. The results revealed that immature E contains a NGF domain…
Viren Shah, Justin Womack, Anthony E. Zamora, Scott S. Terhune + 1 more
'Ranjan K. Dash'] Abstract– Immunotherapies have been proven to have significant therapeutic efficacy in the treatment of cancer. The last decade has seen adoptive cell therapies, such as chimeric antigen receptor T-cell (CART-cell) therapy, gain FDA approval against specific cancers. Additionally, there are numerous…