19 papers · ranked by Valyu relevance
Serban Ciotlos, Qing Mao, Rebecca Yu Zhang, Zhenyu Li + 5 more
'Natali Gulbahce' 'Sophie Jia Liu' 'Radoje Drmanac' 'Brock A. Peters'] Background The cell line BT-474 is a popular cell line for studying the biology of cancer and developing novel drugs. However, there is no complete, published genome sequence for this highly utilized scientific resource. In this study we sought to…
Hye-Sook Seo, Jae Kyung Jo, Jin Mo Ku, Han-Seok Choi + 10 more
'Youn\xa0Kyung Choi' 'Jong-Kyu Woo' 'Hyo in Kim' 'Soo-yeon Kang' 'Kang min Lee' 'Koong\xa0Won Nam' 'Namkyu Park' 'Bo-Hyoung Jang' 'Yong\xa0Cheol Shin' 'Seong-Gyu Ko'] Apigenin induced caspase-dependent extrinsic apoptosis through inhibition of STAT3 signaling in HER2 overexpressing BT-474 breast cancer cells.
Adviti Naik, Aida Al-Yahyaee, Nada Abdullah, Juda-El Sam + 3 more
'Noura Al-Zeheimi' 'Mahmoud W. Yaish' 'Sirin A. Adham'] Background Neuropilin-1 (NRP-1), a non-tyrosine kinase glycoprotein receptor, is associated with poor prognosis breast cancer, however transcriptomic changes triggered by NRP-1 overexpression and its association with chemoresistance in breast cancer have not yet…
Elizabeth Ortiz, Kyaw Hsu Thway, Gabriela Ortiz-Soto, Paulina Yao + 1 more
Breast cancer (BC) is the second leading cause of cancer-related death among women in the U.S. Organoid models of solid tumors have been shown to faithfully recapitulate aspects of cancer progression such as proliferation and invasion. Although patient-derived organoids (PDOs) and patient-derived xenograft organoids…
Tatsuaki Takeda, Hiromasa Yamamoto, Hirotaka Kanzaki, Ken Suzawa + 17 more
Parental BT-474 cell line and established two cell lines BT-474-R and BT-474-RL2 were proven to have the same genetic origins and were authenticated using GenePrint® 10 System (Promega). Morphological changes in the parental cell line and its sublines are shown in [pone.0171356.g001]. To confirm the resistance to…
Tobias Lange, Tobias Groß, Ábris Jeney, Julia Scherzinger + 7 more
Single-cell RNA sequencing (scRNA-seq) can unmask transcriptional heterogeneity facilitating the detection of rare subpopulations at unprecedented resolution. In response to challenges related to coverage and quantity of transcriptome analysis, the lack of unbiased and quantitative validation methods hampers further…
Adebusola Alabi, Anna Ferré-Mateu, Duncan A. Forbes, Aaron J. Romanowsky + 1 more
'Aaron J. Romanowsky' 'Jean P. Brodie'] We present new spectra obtained using Keck/KCWI and perform kinematics and stellar population analyses of the shell galaxy NGC 474, from both the galaxy centre and a region from the outer shell. We show that both regions have similarly extended star formation histories although…
N. Brosch, P. Väisänen, A. Y. Kniazev, А. В. Моисеев
We describe observations of the apparently empty ring galaxy ESO 474-G040 obtained with the Southern African Large Telescope (SALT). The observations, consisting of imaging, long-slit spectroscopy and Fabry-P´erot mapping of the Hα line, allow determining the ring kinematics as well as estimating the metallicity of the…
Eva Habjan, Alexander Lepioshkin, Vicky Charitou, Anna Egorova + 5 more
This study explores benzothiazoles targeting a novel mycobacterial vulnerability, resulting in increased mycobacterial cell envelope permeability and enhanced antibiotic activity.
Andrew O’Brien, R. P. Norris, N. F. H. Tothill, M. D. Filipović
We have completed a deep radio continuum survey covering 86 square degrees of the Spitzer -South Pole Telescope deep field to test whether bent-tail galaxies are associated with galaxy clusters. We present a new catalogue of 22 bent-tail galaxies and a further 24 candidate bent-tail galaxies. Surprisingly, of the 8…
Hesam Makki, Colm Burke, Alessandro Troisi
Morphological and electronic properties of Indacenodithiophene-co-benzothiadiazole (IDTBT) co-polymer with varying molecular weights are calculated through combined molecular dynamics (MD) and quantum chemical (QC) methods. Our study focuses on the polymer chain arrangements, interchain connectivity pathways, and…
Yue Zhang, Tianshuai Zhu, Xian Wei, Yuqian Lin + 7 more
An organo-photoredox catalyzed gem-difluoroallylation of both acyclic and cyclic ketone derivatives with α-trifluoromethyl alkenes has been demonstrated, thus giving access to a diverse set of gem-difluoroalkenes in moderate to high yields. Pro-aromatic dihy-droquinazolinones can be either pre-formed or in situ…
Tomislav Ivezić
In this paper the proofs are given that the electric and magnetic fields are properly defined vectors on the four-dimensional (4D) spacetime (the 4-vectors in the usual notation) and not the usual 3D fields. They are the 4D geometric quantities (GQs). Furthermore, the proofs are presented that under the mathematically…
Authors not listed
The binding of the protein streptavidin (SAv) to biotin-modified DNA origami nanostructures (DONs) is widely employed in the single-molecule study of chemical reactions, the arrangement of functional proteins and nanomaterials with molecular precision, and numerous instances of DON-based cryptography, steganography…
Raavi, Imron Chaudhry, Daniel F. Sheehy, Sean P. Quinnell + 6 more
Interleukin-4 (IL-4) is an important immunoregulatory cytokine involved in T-cell maturation, B-cell activation, and macrophage polarization. Dysregulated IL-4 signaling contributes to several immune-mediated diseases such as cancer, allergic inflammation, and autoimmunity. The clinical use and indication expansion of…
Lucie Denisart, Diana Zapata-Dominguez, Xavier David, Aubin Leclere + 5 more
The manufacturing process of batteries can be complex and time-consuming. We introduce a new version of the digital twin of our lithium ion battery pilot line, Simubat 4.0 Gen-2, based on a new combination of Virtual Reality and Mixed Reality. This digital twin is designed to deliver training on the lithium-ion battery…
Aruna Bitra, Tzanko Doukov, Giuseppe Destito, Michael Croft + 1 more
The interaction between the 4-1BB and its ligand 4-1BBL provides co-stimulatory signals for T cell activation and proliferation, but differences in the mouse and human molecules might result in differential engagement of this pathway. Here, we report the crystal structure of mouse 4-1BBL and of the mouse 4-1BB/4-1BBL…
Yuiko Takebayashi, Javier Ramos-Soriano, Y. Jennifer Jiang, Jennifer Samphire + 9 more
There is great need for novel strategies to tackle antimicrobial resistance, in particular in Gram-negative species such as Escherichia coli that cause opportunistic infections of already compromised patients. Here we demonstrate, following a screen of G-quadruplex (G4) ligand candidates, that a novel…
Authors not listed
Preclinical studies indicate that selective targeting of D4R may improve behavioral and cognitive outcomes in animal models relevant to cognitive disorders, like ADHD and Alzheimer’s disease, and substance use disorders (SUDs). In this study, we extend upon prior development of analogs of A-412997, a D4R-selective…