25 papers · ranked by Valyu relevance
Anas Ahmad, Mohammad Imran, Haseeb Ahsan, George P. Patrinos
A biomarker is any measurable biological moiety that can be assessed and measured as a potential index of either normal or abnormal pathophysiology or pharmacological responses to some treatment regimen. Every tissue in the body has a distinct biomolecular make-up, which is known as its biomarkers, which possess…
Sreyashi Das, Mohan Kumar Dey, Ram Devireddy, Manas Ranjan Gartia + 4 more
'Abdelhamid Errachid' 'Francesca G. Bellagambi' 'Maria Giovanna Trivella' 'Barry K. Lavine'] Biomarkers are vital in healthcare as they provide valuable insights into disease diagnosis, prognosis, treatment response, and personalized medicine. They serve as objective indicators, enabling early detection and…
David S Wishart, Brendan Bartok, Eponine Oler, Kevin Y H Liang + 5 more
'Zachary Budinski' 'Mark Berjanskii' 'AnChi Guo' 'Xuan Cao' 'Michael Wilson'] Title: Abstract MarkerDB is a freely available electronic database that attempts to consolidate information on all known clinical and a selected set of pre-clinical molecular biomarkers into a single resource. The database includes four major…
Elisabeth Drucker, Kurt Krapfenbauer
Since the emergence of the so-called omics technology, thousands of putative biomarkers have been identified and published, which have dramatically increased the opportunities for developing more effective therapeutics. These opportunities can have profound benefits for patients and for the economics of healthcare.…
Chung-Tsen Hsueh, Delong Liu, Hong Wang
A biomarker, as defined by Wikipedia, “is an indicator of a biological state. It is a characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention.” Biomarkers for diagnosis and prognosis…
Dugeshwar Karley, Deepesh Gupta, Archana Tiwari
Cancer is an uncontrolled growth of a cell due to failure in the cell growth signaling system. Cure of cancer is done only by the complete removal of cancerous cells from the body, the process may sound simple but its implementation is almost impossible. There are number of problems regarding its treatment such as its…
Daniall Masood, Mariia Kim, Jeet Vora, Robel Kahsay + 26 more
Biomarkers are essential tools for disease detection, risk assessment, therapeutic monitoring, and precision medicine. However, biomarker data are dispersed across heterogeneous resources, inconsistently reported in the literature, and rarely standardized for computational use. This fragmentation limits…
Ahtisham Fazeel Abbasi, Shiza Naveed, Muhammad Nabeel Asim, Muhammad Sajjad + 2 more
Biomarkers are the molecular signatures that drive and reflect disease states and are indispensable for disease diagnosis, therapeutic target identification, and drug development. The landscape of biomarker discovery has undergone a transformative shift with the emergence of AI-powered predictive pipelines that can…
Solaiman M. Al-hadlaq, Hanan A. Balto, Wail M. Hassan, Najat A. Marraiki + 2 more
'Najat A. Marraiki' 'Afaf K. El-Ansary' 'Vasco Azevedo'] Chronic diseases constitute a major global burden with significant impact on health systems, economies, and quality of life. Chronic diseases include a broad range of diseases that can be communicable or non-communicable. Chronic diseases are often associated…
Andre Lamurias, Sofia Jesus, Vanessa Neveu, Reza M Salek + 1 more
In 2016, the International Agency for Research on Cancer, part of the World Health Organization, released the Exposome-Explorer, the first database dedicated to biomarkers of exposure for environmental risk factors for diseases. The database contents resulted from a manual literature search that yielded over 8500…
Jeya Balaji Balasubramanian, Kevin E. Kip, Steven E. Reis, Vanathi Gopalakrishnan
Biomarker discovery is critical for both biomedical research and for clinical diagnostic, prognostic, and therapeutic decision-making. They help improve our understanding of the underlying physiological processes within an individual. Discovery of biomarkers from complex biomedical datasets is done using data mining…
N Gogate, D Lyman, K.A Crandall, R Kahsay + 3 more
Scientists, medical researchers, and health care workers have mobilized worldwide in response to the outbreak of COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; SCoV2). Preliminary data have captured a wide range of host responses, symptoms, and lingering problems post-recovery within…
Rumiana Tenchov, Aparna Sapra, Janet Sasso, Krittika Ralhan + 3 more
Cancer is one of the leading causes of death worldwide. Early cancer detection is critical because it can significantly improve treatment outcome thus saving lives, reducing suffering, and lessening psychological and economic burdens. Cancer biomarkers provide varied information about cancer, from early detection of…
Authors not listed
Machine learning holds significant promise for accelerating biomarker discovery in clinical proteomics, yet its real-world impact remains limited by widespread methodological pitfalls and unrealistic expectations. In this perspective, we critically examine the integration of machine learning into clinical proteomics…
Katharina Waury
Discovery of novel protein biomarkers for clinical applications is an active research field across a manifold of diseases. Despite some successes and progress, the biomarker development pipeline still frequently ends in failure as biomarker candidates cannot be validated or translated to immunoassays. Selection of…
Kushner, Jared A, Pandey, Mohit + 3 more
As the global population continues to age, there is an increasing demand for ways to accurately quantify the biological processes underlying aging. Biological age, unlike chronological age, reflects an individual's physiological state, offering a more accurate measure of health-span and age-related decline. Aging is a…
Adva Raz, Hila Gubi, Adam Cohen, Fernando Patolsky
Biomarkers detection have become essential in medical diagnostics and early detection of life-threatening diseases. Modern-day medicine relies heavily on painful and invasive tests, the extraction of large volumes of venous blood being the most common tool of biomarker detection. These tests are time-consuming…
Authors not listed
Immuno-oncology, a rapidly evolving field at the forefront of cancer research, leverages the body’s immune system to fight cancer. In this follow up report, we extend our natural language processing (NLP)-based analysis to pinpoint the context of emergence of the previously identified emerging concepts. To achieve this…
A. Adam Ding, Natalie DelRocco, Samuel S. Wu
Biomarker is a critically important tool in modern clinical diagnosis, prognosis, and classification/prediction. However, there are fiscal and analytical barriers to biomarker research. Selective Genotyping is an approach to increasing study power and efficiency where individuals with the most extreme phenotype…
Authors not listed
Accurate and reproducible dietary assessment remains a persistent challenge in clinical and nutritional sciences. We present a validated, liquid chromatography–tandem mass spectrometry (LC-MS/MS) method for the absolute quantification of 200 literature-curated food biomarkers across 500 single-ingredient food extracts…
Frederico G. C. Arnoldi, Rodrigo F. Rodrigues, Célio Lopes Silva
In medical sciences, a biomarker is "a characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention". Molecular experiments are providing rapid and systematic approaches to search for biomarkers…
Svetlana Cherlin, Theophile Bigirumurame, Michael J. Grayling, Jérémie Nsengimana + 5 more
'Jérémie Nsengimana' 'Luke Ouma' 'Aida Santaolalla' 'Fang Wan' 'S. Faye Williamson' 'James Wason'] Introduction: Even in effectively conducted randomised trials, the probability of a successful study remains relatively low. With recent advances in the next-generation sequencing technologies, there is a rapidly growing…
Wangyang Ying, Dongjie Wang, Xuanming Hu, Ji Qiu + 2 more
Bio-Knowledge-Embedded Continuous Space Exploration Authors: ['Wangyang Ying' 'Dongjie Wang' 'Xuanming Hu' 'Ji Qiu' 'Jin G. Park' 'Yanjie Fu'] Biomarker discovery is vital in advancing personalized medicine, offering insights into disease diagnosis, prognosis, and therapeutic efficacy. Traditionally, the identification…
Allison Meisner, Marco Carone, Margaret S. Pepe, Kathleen F. Kerr
Biomarkers abound in many areas of clinical research, and often investigators are interested in combining them for diagnosis, prognosis, or screening. In many applications, the true positive rate for a biomarker combination at a prespecified, clinically acceptable false positive rate is the most relevant measure of…
Rahul Sharma, Amit Patel
Salivary diagnostics offers a promising method for early diagnosis, prognosis, and post-therapy monitoring. Saliva contains various hormones, proteins, enzymes, antibodies, antimicrobial constituents, and cytokines that can provide diagnostic information. Saliva is easy to collect, non- invasive, cost-effective, and…