23 papers · ranked by Valyu relevance
Henry Y. Lu, Bradly M. Bauman, Swadhinya Arjunaraja, Batsukh Dorjbal + 3 more
The caspase recruitment domain family member 11 (CARD11 or CARMA1)-B cell CLL/lymphoma 10 (BCL10)-MALT1 paracaspase (MALT1) [CBM] signalosome complex serves as a molecular bridge between cell surface antigen receptor signaling and the activation of the NF-κB, JNK, and mTORC1 signaling axes. This positions the CBM…
Mélanie Juilland, Margot Thome
The scaffold proteins CARMA1-3 (encoded by the genes CARD11, -14 and -10) and CARD9 play major roles in signaling downstream of receptors with immunoreceptor tyrosine activation motifs (ITAMs), G-protein coupled receptors (GPCR) and receptor tyrosine kinases (RTK). These receptors trigger the formation of oligomeric…
Jens Staal, Yasmine Driege, Alice Borghi, Paco Hulpiau + 10 more
Type 1 paracaspases originated in the Ediacaran geological period before the last common ancestor of bilaterans and cnidarians (planulozoa). Cnidarians have several paralog type 1 paracaspases, type 2 paracaspases, and a homolog of Bcl10. Notably in bilaterans, lineages like nematodes and insects lack Bcl10 whereas…
Jens Staal, Yasmine Driege, Mira Haegman, Alice Borghi + 12 more
'Paco Hulpiau' 'Laurens Lievens' 'Ismail Sahin Gul' 'Srividhya Sundararaman' 'Amanda Gonçalves' 'Ineke Dhondt' 'Jorge H. Pinzón' 'Bart P. Braeckman' 'Ulrich Technau' 'Yvan Saeys' 'Frans van Roy' 'Rudi Beyaert'] The CARD-coiled coil (CC)/Bcl10/MALT1-like paracaspase (CBM) signaling complexes composed of a CARD-CC family…
Annamaria Sgromo, Tobias Raisch, Praveen Bawankar, Dipankar Bhandari + 4 more
'Ying Chen' 'Duygu Kuzuoğlu-Öztürk' 'Oliver Weichenrieder' 'Elisa Izaurralde'] Human (Hs) Roquin1 and Roquin2 are RNA-binding proteins that promote mRNA target degradation through the recruitment of the CCR4-NOT deadenylase complex and are implicated in the prevention of autoimmunity. Roquin1 recruits CCR4-NOT via a…
J. Randall McAuley, Tanner J. Freeman, Prasanna Ekambaram, Peter C. Lucas + 1 more
'Peter C. Lucas' 'Linda M. McAllister-Lucas'] The CARMA-Bcl10-MALT1 (CBM) signalosome is an intracellular protein complex composed of a CARMA scaffolding protein, the Bcl10 linker protein, and the MALT1 protease. This complex was first recognized because the genes encoding its components are targeted by mutation and…
Asaminew H. Aytenfisu, Daniel Deredge, Erik H. Klontz, Jonathan Du + 2 more
Antibodies bind foreign antigens with high affinity and specificity leading to their neutralization and/or clearance by the immune system. The conserved N-glycan on IgG has significant impact on antibody effector function, with the endoglycosidases of Streptococcus pyogenes deglycosylating the IgG to evade the immune…
Dmitrii Fedorov, Piotr Batys, Maria Sammalkorpi, Markus B. Linder
Cellulose binding modules (CBMs) are found widely in different proteins that act on cellulose. Because they allow a very easy way of binding recombinant proteins to cellulose, they have become widespread in many biotechnological applications involving cellulose. One commonly used variant is the CBM_CipA_ from…
Natalia Łoś, Ieva Lelėnaitė, William G. T. Willats, Nicolas Terrapon + 4 more
β-mannans are plant structural and storage polysaccharides prevalent in the human diet. Their degradation in the gastrointestinal tract is mediated by the human gut microbiota (HGM) through expression of a plethora of carbohydrate-active enzymes (CAZymes), although our understanding of the details of mannan breakdown…
Ruhi Rahman, Sara E. Scanlan, Fady Sidarous, Jonathan D. Monroe + 1 more
Flowering plants contain a plastid-localized ɑ-amylase (AMY3) with several recognized domains: two N-terminal carbohydrate-binding modules, an alpha-alpha hairpin that binds the catalytically inactive activator β-amylase9, and a C-terminal catalytic domain. Despite considerable research on leaf starch metabolism in…
Sunit Pal, Ilja Gordijenko, Stefan Schmeing, Somarghya Biswas + 3 more
The removal of poly(A) tail from mRNA sequences reduces their stability and translational activity. The deadenylation process is mainly regulated by the CCR4-NOT complex for which potent chemical inhibitors are rare. The subunit NOT9 binds various RNA binding proteins (RBPs) which recruit mRNA in a sequence-specific…
Frédéric Bornancin, Andrew L. Snow
Over the past 20 years, enhanced analyses of tumor-specific genomic alterations coupled with elegant biochemical approaches have helped to map essential signaling pathways in healthy and malignant cells. For example, the B cell lymphoma/leukemia 10 (BCL10) gene was identified in 1999 from a recurrent chromosomal…
Joseph Southgate, Katrina M. Groth, Peter Sandborn, Shapour Azarm
Monte Carlo Simulations for Condition-based Maintenance of Unmanned Systems Authors: ['Joseph Southgate' 'Katrina M. Groth' 'Peter Sandborn' 'Shapour Azarm'] Recent developments in condition-based maintenance (CBM) have helped make it a promising approach to maintenance cost avoidance in engineering systems. By…
Markus Hackl, Edward V. Contrada, Jonathan E. Ash, Atharv Kulkarni + 5 more
To rationally engineer more efficient cellulolytic enzymes for cellulosic biomass deconstruction into sugars for biofuels production, it is necessary to better understand the complex enzyme-substrate interfacial interactions. Carbohydrate binding modules (CBM) are often associated with microbial surface-tethered…
Asaminew H. Aytenfisu, Daniel Deredge, Erik H. Klontz, Jonathan Du + 3 more
'Eric J. Sundberg' 'Alexander D. MacKerell Jr' 'David van der Spoel'] Antibodies bind foreign antigens with high affinity and specificity leading to their neutralization and/or clearance by the immune system. The conserved N-glycan on IgG has significant impact on antibody effector function, with the endoglycosidases…
I. M. Deppner, N. Herrmann
In order to provide particle identification (PID) of charged hadrons at the future highrate Compressed Baryonic Matter (CBM) experiment, the TOF group has developed a large-area Time-of-Flight (ToF) wall equipped with Multi-gap Resistive Plate Chambers (MRPC) capable to operate at incident particle fluxes of up to 30…
Hang Ma, Sven Koenig
We study the TAPF (combined target-assignment and pathfinding) problem for teams of agents in known terrain, which generalizes both the anonymous and non-anonymous multiagent path-finding problems. Each of the teams is given the same number of targets as there are agents in the team. Each agent has to move to exactly…
Demi D. Snabilié, Bas de Bruin, Rens Ham, Joost N. H. Reek
Radical-type carbene transfer catalysis is an efficient method for the direct functionalization of C–H and C=C bonds. However, carbene radical complexes are currently formed via high-energy carbene precursors, such as diazo compounds or iodonium ylides. Many of these carbene precursors require additional synthetic…
Authors not listed
“Click to release” chemistry enables bioorthogonal bond cleavage and controlled release via a click-type ligation reaction serving as both the trigger and means of localization. Extending this concept beyond covalent ligation reactions, we introduce a non-covalent click-to-release strategy based on…
P. Hanlet
Operation of complex systems which depend on one, or more, sub-systems with many process variables often operate in more than one state. For each state there may be a variety of parameters of interest, and for each of these, one may require different alarm limits, different archiving needs, and have different critical…
Authors not listed
Three new lanthanide complexes of the general form [Ln(Cnt)(CntInd)] (Ln = Ce, Pr, and Nd, Cnt = cyclononatetraenyl, and CntInd = cyclononatetraenyl-dihydroindene) have been synthesized from the corresponding LnI3 salt and several equivalents of the KCnt ligand. A novel C-C coupling has been observed between one Cnt-…
Clinton Enwerem, John S. Baras
— We consider the problem of safely coordinating ensembles of identical autonomous agents to conduct complex missions with conflicting safety requirements and under noisy control inputs. Using non-smooth control barrier functions (CBFs) and stochastic model-predictive control as springboards, and by adopting an…
Benedek Stadler, Nikolaus Gorgas, Andrew White, Mark Crimmin
Herein we present the first double deprotonation of acetonitrile (CH3CN) using a bimetallic iron-aluminium complex. The products of this reaction contain an exceeding simple yet rare [CHCN]2– dianion moiety that bridges two metal fragments. DFT calculations suggest that the bonding to the metal centres is primarily…