19 papers · ranked by Valyu relevance
Kenji Hashimoto, Helmout Modjtahedi
Simple Summary CD137 is an interesting immuno-oncology target. The recent advances in CD137 targeting technologies to mitigate toxicity while maintaining potency have made this space even more attractive. In this article, our current understanding of CD137 biology is reviewed along with data from clinical trials…
Ling Yi, Yanlin Zhao, Xiaojue Wang, Min Dai + 4 more
'Ingegerd Hellström' 'Hongtao Zhang' 'Mitchell Ho'] Monoclonal antibodies (mAbs) to CD137 (a.k.a. 4-1BB) have anti-tumor efficacy in several animal models and have entered clinical trials in patients with advanced cancer. Importantly, anti-CD137 mAbs can also ameliorate autoimmunity in preclinical models. As an…
Veronica Gusti, Kaila M. Bennett, David D. Lo
Treatment of Caco-2-BBe intestinal epithelial cells (BBe) with TNF-α and lymphotoxin-β (LT-β) receptor agonists induced the expression of the TNF receptor superfamily gene TNFRSF9/CD137. In the gut, these cytokines are known to be involved in both inflammatory responses and development of organized lymphoid tissues…
Juan M. Zapata, Gema Perez-Chacon, Pablo Carr-Baena, Ivan Martinez-Forero + 3 more
'Ivan Martinez-Forero' 'Arantza Azpilikueta' 'Itziar Otano' 'Ignacio Melero'] CD137 (4-1BB, Tnsfr9) is a member of the TNF-receptor (TNFR) superfamily without known intrinsic enzymatic activity in its cytoplasmic domain. Hence, akin to other members of the TNFR family, it relies on the TNFR-Associated-Factor (TRAF)…
Khang Luu, Mugdha Vijay Patwardhan, Qun Zeng, Stina L. Wickström + 3 more
'Andreas Lundqvist' 'Herbert Schwarz' 'Fawzi Aoudjit'] CD137 is a costimulatory molecule expressed on activated T cells. CD137 ligand (CD137L) is expressed by antigen presenting cells (APC), which use the CD137-CD137L system to enhance immune responses. It was, therefore, surprising to discover CD137 expression on…
Beom K. Choi, Hyeon-Woo Lee
CD137, a member of the TNFR family, is a costimulatory receptor, and CD137L, a member of the TNF family, is its ligand. Studies using CD137- and CD137L-deficient mice and antibodies against CD137 and CD137L have revealed the diverse and paradoxical effects of these two proteins in various cancers, autoimmunity…
Wei Zhong, Bo Li, Xiao Yang Li, Zhong Qun Wang + 4 more
'Cui Ping Wang' 'Rui Chen' 'Jin Chuan Yan'] Previous studies showed little CD137 expressed in normal vascular smooth muscle cells (VSMCs) and it is important to find a valid way to elevate it before studying its function. The level of CD137 was detected by RT-PCR, western blot, and flow cytometry, respectively. CD137…
Richard J Beck, Bettina Weigelin, Joost B Beltman
Several immunotherapeutic strategies for the treatment of cancer are under development. Two prominent strategies are adoptive cell transfer (ACT) of cytotoxic T lymphocytes (CTLs) and modulation of CTL function with immune checkpoint inhibitors or with costimulatory antibodies. Despite some success with these…
Anders W. Matson, Rob H. Hullsiek, Kate J. Dixon, Sam Wang + 9 more
NK cells are being extensively studied as a cell therapy for cancer. Their effector functions are induced by the recognition of ligands on tumor cells and by various cytokines. IL-15 is broadly used to stimulate endogenous and adoptively transferred NK cells in cancer patients. These stimuli activate the membrane…
Monika A. Eiva, Dalia K. Omran, Jessica Chacon, Daniel J. Powell
The detection of tumor-specific T cells in solid tumors is integral to the interrogation of endogenous antitumor responses and to the advancement of downstream therapeutic applications, such as checkpoint immunotherapy and adoptive cell transfer. A number of biomarkers are reported to identify endogenous tumor-specific…
Juliane Mietz, Meike Kaulfuss, Lukas Egli, Lennart Opitz + 2 more
The functional relevance of CD8^+^ T cell phenotypes in human cancer is not well established. In preclinical studies, murine CD8^+^ T cells exhibiting an exhausted-like phenotype have been described to have drastically decreased anticancer activity while non-exhausted TCF-1^+^ progenitor CD8^+^ T cells have been…
Berenice Martínez-Salazar, José Delgado-Domínguez, Julio Estrada, César González-Bonilla + 1 more
'César González-Bonilla' 'Ingeborg Becker'] Leishmania lipophosphoglycan (LPG) is a molecule that has been used as a vaccine candidate, with contradictory results. Since unsuccessful protection could be related to suppressed T cell responses, we analyzed the expression of inhibitory receptor PD-1 in CD8+ and CD4+…
Laura Díaz-Alvarez, Mariana Esther Martínez-Sánchez, Eleanor Gray, Enrique Ortega
Upon ligand engagement, certain receptors can activate an integrin through a mechanism called inside-out signalling. This phenomenon prepares the cell for the next steps of the process it will perform. CR3 (Complement receptor 3), the most abundant β2 integrin in monocytes and macrophages, and CD13 (aminopeptidase N)…
Qiang Hao, Pathum Wathudura, Huy Pham, In Han Ha + 6 more
Chiroptical spectroscopy provides a non-invasive, label-free approach for resolving microscopic structural details via interactions with circularly polarized light. Despite the widespread application and complementary information provided for chiroptical materials characterization, the simultaneous acquisition of…
Authors not listed
Hodgkin’s lymphoma is a malignancy (cancer) that affects the immune system, primarily lymphocytes (white blood cells). CD30 is a protein receptor expressed on the surface of Hodgkin's cancer cells and is a crucial target for diagnosis and treatment. As of now, current CD30-targeted therapies come with extensive side…
Authors not listed
Leaves have recently emerged as a popular sustainable and abundant source for the synthesis of optically active carbon dots (CDs), in part because their rich chemical composition could enable for the formation of a wide variety of CD properties. However, this chemical complexity also poses a significant challenge for…
Qasim Ali, I.H. Mustafa, Ali Elkamel, Éric Touboul + 2 more
'Claude Lambert'] The down regulation of CD3 protein present on the surface of a T-cell triggers the process of activation. A rapid decrease of CD3 from the surface is required to reach the threshold that is necessary for the continuation of the activation process. By flow cytometry technique, it is well established…
Authors not listed
A steep, age‑related drop in nicotinamide adenine dinucleotide (NAD+) now ranks among the most reproducible molecular signatures of human aging, driving metabolic slowdown, mitochondrial dysfunction, DNA‑repair deficits, chronic inflammation, and stem‑cell fatigue. Boost NAD+ for Anti‑Aging: A Multidimensional Review…
Soren Ghorai, Ashley Pearson
Chimeric antigen receptor T (CAR-T) cell therapy has transformed the field of immunology by redirecting T lymphocytes toward tumor antigens. Despite successes in attaining remission rates as high as 70%, the performance of CAR therapy is limited by the survival of T cells. T cell persistence is crucial as it sustains…