15 papers · ranked by Valyu relevance
Silvia Moncini, Alessandro Salvi, Paola Zuccotti, Gabriella Viero + 6 more
'Alessandro Quattrone' 'Sergio Barlati' 'Giuseppina De Petro' 'Marco Venturin' 'Paola Riva' 'Michael Polymenis'] CDK5R1 encodes p35, a specific activator of the serine/threonine kinase CDK5, which plays crucial roles in CNS development and maintenance. CDK5 activity strongly depends on p35 levels and p35/CDK5…
Silvia Moncini, Annamaria Bevilacqua, Marco Venturin, Claudia Fallini + 3 more
'Claudia Fallini' 'Antonia Ratti' 'Angelo Nicolin' 'Paola Riva'] Background CDK5R1 plays a central role in neuronal migration and differentiation during central nervous system development. CDK5R1 has been implicated in neurodegenerative disorders and proposed as a candidate gene for mental retardation. The remarkable…
Carrie Draney, Amanda E. Hobson, Samuel G. Grover, Benjamin O. Jack + 1 more
'Jeffery S. Tessem'] Decreased β-cell mass is a hallmark of type 1 and type 2 diabetes. Islet transplantation as a method of diabetes therapy is hampered by the paucity of transplant ready islets. Understanding the pathways controlling islet proliferation may be used to increase functional β-cell mass through…
Zhili Zeng, Zebiao Cao, Enxin Zhang, Haifu Huang + 1 more
Background: Hepatocellular carcinoma (HCC) is a malignant tumor with rapid progression, high recurrence rate and poor prognosis. The objective of our investigation was to explore the prognostic value of CDK5R1 in HCC. Methods: The raw data of HCC raw data were downloaded from The Cancer Genome Atlas (TCGA) database.…
Kumar Nikhil, Kavita Shah
Recent studies have uncovered various physiological functions of CDK5 in many nonneuronal tissues. Upregulation of CDK5 and/or its activator p35 in neurons promotes healthy neuronal functions, but their overexpression in nonneuronal tissues is causally linked to cancer of many origins. This review focuses on the…
Wan Liu, Jun Li, Yu-Shu Song, Yue Li + 2 more
As an atypical member of cyclin dependent kinase family, Cyclin dependent kinase 5 (Cdk5) is considered as a neuron-specific kinase in the past decade due to the abundant existence of its activator p35 in post-mitotic neurons. Recent studies show that Cdk5 participates in a series of biological and pathological…
Manindra Nath Tiwari, Bradford E. Hall, Anita Terse, Niranjana Amin + 2 more
Chronic pain is one of the most devastating and unpleasant conditions, associated with many pathological conditions. Tissue or nerve injuries induce comprehensive neurobiological plasticity in nociceptive neurons, which leads to chronic pain. Recent studies suggest that cyclin-dependent kinase 5 (CDK5) in primary…
Nicola J. Grant, Philip J. Coates, Yvonne L. Woods, Susan E. Bray + 5 more
'Nicholas A. Morrice' 'C. James Hastie' 'Douglas J. Lamont' 'Francis A. Carey' 'Calum Sutherland'] Background Cyclin-dependent protein kinase-5 (CDK5) is an unusual member of the CDK family as it is not cell cycle regulated. However many of its substrates have roles in cell growth and oncogenesis, raising the…
Yasumi Otani, Emily Goodall, Vignesh Srinivasan, Neil J Ball + 4 more
Cyclin-dependent kinase-like 5 (CDKL5) is a serine/threonine kinase essential for brain development and function. Mutations in the CDKL5 gene cause CDKL5 deficiency disorder (CDD), a severe early-onset epileptic encephalopathy characterised by defects in synapse formation and function. Despite extensive research, the…
Lucas E. Cabrera Zapata, Carla D. Cisternas, Camila Sosa, Maria Angeles Arevalo + 2 more
Several X-linked genes are involved in neuronal differentiation and may contribute to the generation of sex dimorphisms in brain. Previous results showed that XX hypothalamic neurons grow faster, have longer axons, and exhibit higher expression of the neuritogenic gene neurogenin 3 (Ngn3) than XY before perinatal…
Paolo La Montanara, Arnau Hervera, Lucas Baltussen, Thomas Hutson + 14 more
Cyclin-dependent-like kinase 5 (Cdkl5) gene mutations lead to an X-linked disorder that is characterized by infantile epileptic encephalopathy, developmental delay and hypotonia. However, we found that a substantial percentage of these patients also report a previously unrecognised anamnestic deficiency in pain…
Han Wee Ong, Yi Liang, William Richardson, Emily R. Lowry + 12 more
Despite mediating several essential processes in the brain, including during development, cyclin-dependent kinase-like 5 (CDKL5) remains a poorly characterized human protein kinase. Accordingly, its substrates, functions, and regulatory mechanisms have not been fully described. We realized that availability of a potent…
Guergana Tchakarska, Brigitte Sola
Abbreviations: aa, amino acid ; AR, androgen receptor; ATM, ataxia telangectasia mutant; ATR, ATM and Rad3-related; CDK, cyclin-dependent kinase; ChREBP, carbohydrate response element binding protein; CIP, CDK-interacting protein; CHK1/2, checkpoint kinase 1/2; CKI, CDK inhibitor; DDR, DNA damage response; DMP1, cyclin…
Haitao Chen, Robert Bird, DaSheng Wang, Leilani Lotti Diaz + 5 more
CCovalent inhibitors are being used more frequently in drug discovery and is expected to revolutionize how enzyme inhibitors and receptor modulators are created in the future. More than 30 covalent therapies have been approved by the US FDA as a result of this approach, which has produced a wide spectrum of effective…
Maksym Tsytlonok, Hugo Sanabria, Yuefeng Wang, Suren Felekyan + 11 more
'Katherina Hemmen' 'Aaron H. Phillips' 'Mi‐Kyung Yun' 'M. Brett Waddell' 'Cheon‐Gil Park' 'Sivaraja Vaithiyalingam' 'Luigi I. Iconaru' 'Stephen W. White' 'Péter Tompa' 'Claus A. M. Seidel' 'Richard W. Kriwacki'] p27Kip1 (p27) is an intrinsically disordered protein (IDP) that folds upon binding to cyclin‐dependent…