19 papers · ranked by Valyu relevance
Jianpan Huang, Zilin Chen, Se-Weon Park, Joseph H. C. Lai + 3 more
'Kannie W. Y. Chan' 'Sangeeta Ray' 'Ethel J. Ngen'] Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) detects molecules in their natural forms in a sensitive and non-invasive manner. This makes it a robust approach to assess brain tumors and related molecular alterations using endogenous…
Chu Chen, Yang Liu, Se Weon Park, Jizhou Li + 2 more
'Raymond H. Chan'] Chemical Exchange Saturation Transfer (CEST) MRI demonstrates its capability in significantly enhancing the detection of proteins and metabolites with low concentrations through exchangeable protons. The clinical application of CEST, however, is constrained by its low contrast and low signal-to-noise…
Aditya N. Bade, Howard E. Gendelman, JoEllyn McMillan, Yutong Liu
Human immunodeficiency virus type-1 (HIV-1) antiretroviral drug (ARV) theranostics facilitates biodistribution and efficacy of therapies designed to target viral reservoirs. To this end, we have now deployed intrinsic drug chemical exchange saturation transfer (CEST) contrast to detect ARV distribution within the…
Chu Chen, Aitor Artola, Yang Liu, Se Weon Park + 3 more
Chemical Exchange Saturation Transfer (CEST) MRI enables molecular-level visualization of lowconcentration metabolites by leveraging proton exchange dynamics. However, its clinical translation is hindered by inherent challenges: spatially varying noise arising from hardware limitations, and complex imaging protocols…
Jiawen Wang, Pei Cai, Ziyan Wang, Huabin Zhang + 1 more
Methods: CEST MRI data were acquired from twelve healthy volunteers at 3T. Data from ten subjects were used for training, while the remaining two were reserved for testing. The performance of multi-layer perceptron (MLP) and KAN models with the same network settings were evaluated and compared to the conventional…
Hans-Jörg Wittsack, Karl Ludger Radke, Julia Stabinska, Alexandra Ljimani + 1 more
Analysis of chemical exchange saturation transfer (CEST) MRI data requires sophisticated methods to obtain reliable results about metabolites in the tissue under study. CEST generates z-spectra with multiple components, each originating from individual molecular groups. The individual lines with Lorentzian line shape…
Göran Carlström, Theresa Höfurthner, Mikael Akke
Chemical exchange saturation transfer (CEST) has become an indispensable NMR method to characterize slow exchange affecting biomacromolecules, especially for cases involving exchange between a major state and a minor state, the latter of which is often invisible in the spectrum. The CEST method is based on successive…
Patrick Liebig, Maria Sedykh, Kai Herz, Moritz Fabian + 5 more
Amide proton transfer weighted imaging is a metabolic MRI technique based on chemical exchange saturation transfer (CEST) with the ability of tumor detection and subtyping1 . CEST MRI suffers from long preparation times and consequently long acquisition times as well as the interplay of the acquisition onto the…
Yupeng Wu, Qifan Pang, Zhichao Wang, Gaiying Li + 6 more
'Mengqiu Cao' 'X. Wang' 'Yang Song' 'Zhao Yu' 'Jianqi Li'] Spectrally selective 3D chemical exchange saturation transfer (CEST) imaging typically demands single-shot readouts for the sake of time-saving, so as to simultaneously fit multiple CEST effects. However, up to now, only fast low angle shot (FLASH) and echo…
Yang Liu, Se Weon Park, Lok Hin Law, Kexin Wang + 4 more
1## INTRODUCTION CEST MRI is a promising molecular imaging technique that can detect low-concentration molecules via the exchange between the water protons and exchangeable solute protons., It has been widely used to image many endogenous contrasts, such as proteins or peptides (amide proton transfer [APT]),, glutamate…
Daniel Paech, Moritz Zaiss, Jan-Eric Meissner, Johannes Windschuh + 12 more
'Benedikt Wiestler' 'Peter Bachert' 'Jan Oliver Neumann' 'Philipp Kickingereder' 'Heinz-Peter Schlemmer' 'Wolfgang Wick' 'Armin Michael Nagel' 'Sabine Heiland' 'Mark Edward Ladd' 'Martin Bendszus' 'Alexander Radbruch' 'Karl Herholz'] Background and Purpose Nuclear Overhauser Enhancement (NOE) mediated chemical exchange…
Ouri Cohen, Robert J. Young, Or Perlman, Christian T. Farrar + 1 more
'Ricardo Otazo'] Methods: A CEST-MRF pulse sequence originally designed for animal imaging was modified to conform to hardware limits on clinical scanners while keeping scan time ≤ 2 minutes. Quantitative MRF reconstruction was performed using a deep reconstruction network (DRONE) to yield the water relaxation and…
Pejman Jabehdar Maralani, Rachel W. Chan, Wilfred W. Lam, Wendy Oakden + 8 more
'Wendy Oakden' 'Ryan Oglesby' 'Angus Lau' 'Hatef Mehrabian' 'Chris Heyn' 'Aimee K.M. Chan' 'Hany Soliman' 'Arjun Sahgal' 'Greg J. Stanisz'] Chemical exchange saturation transfer (CEST) is a relatively novel magnetic resonance imaging (MRI) technique with an image contrast designed for in vivo measurement of certain…
Yashwant Kurmi, Malvika Viswanathan, Zhongliang Zu
To develop a SNR enhancement method for chemical exchange saturation transfer (CEST) imaging using a denoising convolutional autoencoder (DCAE), and compare its performance with state-of-the-art denoising methods. The DCAE-CEST model encompasses an encoder and a decoder network. The encoder learns features from the…
Stephan Knecht, Sara Hadjiali, Danila Barskiy, Alexander Pines + 5 more
For the first time chemical-exchange saturation transfer (CEST) 1H NMR is utilized for the study of short-lived hydride intermediates in the catalytic cycle of the Iridium-based organometallic complex [Ir(IMes)(Py)3(H)2]Cl, which are often not observable by other NMR techniques, since they are low concentrated, and…
Chuyu Liu, Nan Gao, Haiqi Ren, Hao Liu + 7 more
Chemical exchange saturation transfer (CEST) MRI could detect proteins/peptides, creatine, glucose, and glycogen by labeling their exchangeable amide, amine, and hydroxyl groups respectively, via frequency-selective RF pulses. Without the need for contrast agents or specialized hardware, CEST can be conveniently…
Jianping Xu, Tao Zu, Yi‐Cheng Hsu, Yi Sun + 3 more
'Yi Zhang'] Theory and Methods: Inspired by the variational network, the CEST image reconstruction equation is unrolled into a deep neural network (CEST-VN) with a kspace data-sharing block that takes advantage of the inherent redundancy in adjacent CEST frames and 3D spatial-frequential convolution kernels that…
Yu Zhao, Casey Sun, Zhongliang Zu
Quantifications of amide proton transfer (APT) and nuclear Overhauser enhancement (NOE(−3.5)) mediated transfer with high specificity are challenging since their signals measured in a Z-spectrum are overlapped with confounding signals from direct water saturation (DS), semi-solid magnetization transfer (MT) and…
Cameron Runte, Umang Jain, Landon J. Getz, Sabrina Secord + 7 more
Enteropathogenic Escherichia coli (EPEC) are worldwide human enteric pathogens inflicting significant morbidity and causing large economic losses. A type 3 secretion system (T3SS) is critical for EPEC intestinal colonization, and injection of effectors into host cells contributes to cellular subversion and innate…